Selective neuropsychological impairments and related clinical factors in children with moyamoya disease of the transient ischemic attack type
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Moyamoya disease is characterized by progressive narrowing of bilateral internal carotid arteries. Neuropsychological impairments are suspected due to frequent involvement of the frontotemporal areas. The present study thus aimed to investigate the pattern of neuropsychological function in children diagnosed with moyamoya disease.
Thirteen children with moyamoya disease of the transient ischemic attack type received standardized neuropsychological tests that evaluate general intellectual function, verbal comprehension, perceptual organization, working memory, processing speed, episodic memory, category fluency and visuospatial function. Related clinical factors were also analyzed.
The results showed single-domain cognitive impairment in around 15 % of patients and multiple-domain cognitive impairments in 23 % of patients. Selective impairments of episodic memory and processing speed were especially noted in those with younger age of onset and prolonged symptom duration.
Neuropsychological impairments are not infrequent in children with moyamoya disease despite normal general intellectual functioning. The pattern of cognitive dysfunction is often associated with lesions in frontotemporal areas. Early detection and intervention shall be considered regarding cognitive outcome in pediatric group.
KeywordsChildren Moyamoya disease TIA Neuropsychological function Intelligence
This work was partially supported by the National Science Council of Taiwan (grant number NSC101-2321-b-182-014).
- 12.Kuroda S, Houkin K, Ishikawa T, Nakayama N, Ikeda J, Ishii N, Kamiyama H, Iwasaki Y (2004) Determinants of intellectual outcome after surgical revascularization in pediatric moyamoya disease: a multivariate analysis. Childs Nerv Syst 20:302–308. doi: 10.1007/s00381-004-0924-4 PubMedCrossRefGoogle Scholar
- 15.Calviere L, Catalaa I, Marlats F, Viguier A, Bonneville F, Cognard C, Larrue V (2010) Correlation between cognitive impairment and cerebral hemodynamic disturbances on perfusion magnetic resonance imaging in European adults with moyamoya disease. J Neurosurg 113:753–759. doi: 10.3171/2010.4.jns091808 PubMedCrossRefGoogle Scholar
- 19.Wechsler D (2003) Wechsler intelligence scale for children, 4th edn. Harcourt Assessment, San AntonioGoogle Scholar
- 20.Wechsler D (1997) Wechsler adult intelligence scale, 3rd edn. Harcourt Assessment, San AntonioGoogle Scholar
- 21.Wechsler D (1997) Wechsler memory scale, 3rd edn. Harcourt Assessment, San AntonioGoogle Scholar
- 22.Shan IK, Chen YS, Su TP (2004) Developmental normative data on attention, memory, and executive functions in children and adolescents. Arch Clin Psychol 1:21–29Google Scholar
- 24.Baron IS (2003) Neuropsychological evaluation of the child. Oxford University Press, New YorkGoogle Scholar
- 25.Benton AL, Sivan AB, KdeS H, Varney NR, Spreen O (1994) Judgment of line orientation contributions to neuropsychological assessment: a clinical manual, 2nd edn. Oxford University Press, New YorkGoogle Scholar
- 26.Hannay HL, Howieson DB, Loring DW, Fischer JS, Lezek MD (2004) Neuropsychology for neuropsychologists. In: Lezak MD, Howieson DB, Loring DW, Hannay HJ, Fischer JS (eds) Neuropsychological assessment, 4th edn. Oxford University Press, New YorkGoogle Scholar
- 28.Lezak MD, Howieson DB, Loring DW, Hannay HJ, Fischer JS (2004) Neuropsychological assessment, 4th edn. Oxford University Press, New YorkGoogle Scholar
- 29.Turken A, Whitfield-Gabrieli S, Bammer R, Baldo JV, Dronkers NF, Gabrieli JD (2008) Cognitive processing speed and the structure of white matter pathways: convergent evidence from normal variation and lesion studies. Neuroimage 42:1032–1044. doi: 10.1016/j.neuroimage.2008.03.057 PubMedCentralPubMedCrossRefGoogle Scholar