Child's Nervous System

, Volume 28, Issue 4, pp 497–500 | Cite as

Discovery of cerebrovascular moyamoya disease: research during the late 1950s and early 1960s

  • Hideki Oshima
  • Yoichi Katayama
Cover Picture


Carotid angiography employing a percutaneous technique, which was devised by Shimizu in 1937, was popularized among neurosurgeons in Japan soon after World War II. This opened up an opportunity for them to encounter and investigate moyamoya disease, since this disease is more common among Asians. They began to publish their findings on what is currently called moyamoya disease in the Japanese literature during the late 1950s and early 1960s. It was only in the late 1960s, however, that their studies were published in the English literature. The early history of the discovery of this disease is therefore not widely known. In 1957, Takeuchi and Shimizu reported a case of an unknown disease characterized by hypoplasia of the internal carotid arteries. In 1964, Moriyasu and his colleagues published a report of four child cases with occlusion of the internal carotid artery. They also published in the same year a report of five adult cases with occlusion of the internal carotid arteries for an unknown reason, placing special emphasis on an abnormal vascular network located at the base of the brain, which is presently termed moyamoya vessels. In 1968 and 1969, Kudo, Nishimoto, and Takeuchi, as well as Suzuki and Takaku, published their studies in the English literature, which contributed greatly to the recognition of moyamoya disease throughout the world. Takeuchi and Shimizu, and Moriyasu also deserve credit as the researchers who reported the crucial features of moyamoya disease for the first time.


Carotid artery Circle of Willis History Moyamoya disease Occlusion 



We wish to thank Dr S. Nishio of Nihon University for his invaluable comments regarding the historical detail.


  1. 1.
    Akai K, Hashimoto S, Moriyasu N, Nishio S (1966) An autopsy case of cerebral softening with abnormal vascular network in the cerebral basal region. Neurol Med Chir 8:274–275CrossRefGoogle Scholar
  2. 2.
    Kito S (1961) Occlusion of the internal carotid artery. Shinkei Shinpo 5:500–510, in JapaneseGoogle Scholar
  3. 3.
    Kudo T (1965) Considerations on the syndrome with intracranial abnormal vascular network. No To Shinkei 17:781–782, in JapanesePubMedGoogle Scholar
  4. 4.
    Kudo T (1968) Spontaneous occlusion of the circle of Willis. A disease apparently confined to Japanese. Neurology 18:485–496PubMedGoogle Scholar
  5. 5.
    Leeds NE, Abbott KH (1965) Collateral circulation in cerebrovascular disease in childhood via rete mirabile and perforating branches of anterior choroidal and posterior cerebral arteries. Radiology 85:628–634PubMedGoogle Scholar
  6. 6.
    Maki Y, Nakata Y (1965) Autopsy of hemangiomatous malformation of the internal carotid artery at the base of brain. No To Shinkei 17:764–766, in JapanesePubMedGoogle Scholar
  7. 7.
    Moriyasu N (1964) Angiographic and clinical features of cases with cerebrovascular abnormality demonstrating apoplectic symptoms. Nihon Iji Shinpo 2085:16–22, in JapaneseGoogle Scholar
  8. 8.
    Moriyasu N, Nishio S (1965) On the net-like vascular anomaly of the cerebral artery. No To Shinkei 17:761–763, in JapanesePubMedGoogle Scholar
  9. 9.
    Moriyasu N, Nishio S, Satoh K, Fujii T, Akai K, Hashimoto S (1966) On the net-like vascular anomaly of the cerebral artery. Neurol Med Chir 8:262–263CrossRefGoogle Scholar
  10. 10.
    Moriyasu N, Sato K, Nishio S (1964) The occlusion of cerebral artery in children. No To Shinkei 16:409–414, in JapanesePubMedGoogle Scholar
  11. 11.
    Nishimoto A, Sugiu R, Mannami T (1965) Hemangiomatous malformation of bilateral internal carotid artery at the base of brain. No To Shinkei 17:750–756, in JapaneseGoogle Scholar
  12. 12.
    Nishimoto A, Sugiu R, Takeuchi S (1966) Malformation of the circle of Willis presenting a peculiar cerebral angiographic picture. Case encountered in Japan. No To Shinkei 18:508–513, in JapanesePubMedGoogle Scholar
  13. 13.
    Nishimoto A, Takeuchi S (1968) Abnormal cerebrovascular network related to the internal carotid arteries. J Neurosurg 29:255–260PubMedCrossRefGoogle Scholar
  14. 14.
    Nishio S (1964) Studies on some cases with occlusive findings by cerebral angiography, with reference to patients with hemiplegia. Nichidai Igaku Zassi 23:374–386, in JapaneseGoogle Scholar
  15. 15.
    Nomura R (1965) Occlusion of the circle of Willis with varied collaterals. No To Shinkei 17:777–778, in JapanesePubMedGoogle Scholar
  16. 16.
    Sano K (1965) Cerebral juxta basal teleangiectasia. No To Shinkei 17:748–750, in JapanesePubMedGoogle Scholar
  17. 17.
    Shimidzu K (1937) Beitraege zur Arteriographie des Gehirns-einfache percutane Methode. Arch klin Chir 188:295–316, in GermanGoogle Scholar
  18. 18.
    Simon J, Sabouraud O, Guy G, Turpin J (1968) Un cas de maladie de Nishimoto. A propos d'une maladie rare et bilatérale de la carotide interne. Rev Neurol (Paris) 119:376–383, in FrenchGoogle Scholar
  19. 19.
    Suzuki J, Takaku A (1969) Cerebrovascular “moyamoya” disease. Disease showing net-like vessels in base of brain. Arch Neurol 20:288–299PubMedCrossRefGoogle Scholar
  20. 20.
    Suzuki J, Takaku A, Asahi M, Kowada M (1965) Diseases showing “fibrille” like vessels at the base of brain. No To Shinkei 17:767–776, in JapanesePubMedGoogle Scholar
  21. 21.
    Suzuki Y, Takahashi T, Maruyama H, Okada R, Komiya H, Suzuki M (1964) Cerebral vascular insufficiency. Nippon Shounikagakkai Zasshi 68:14–22, in JapaneseGoogle Scholar
  22. 22.
    Takeuchi K, Kobayashi S (1965) Arterial occlusion at the base of brain in children. No To Shinkei 17:779–780, in JapanesePubMedGoogle Scholar
  23. 23.
    Takeuchi K, Shimizu K (1957) Hypoplasia of the bilateral internal carotid arteries. No To Shinkei 9:37–43, in JapaneseGoogle Scholar
  24. 24.
    Tsubokawa T, Kikuchi M, Asano S, Ito H, Urabe M (1964) Surgical treatment for intracranial thrombosis. Case report of “durapexia”. Neurol Med Chir (Tokyo) 6:48–49CrossRefGoogle Scholar
  25. 25.
    Urvanek K, Farkova H, Klaus E (1970) Nishimoto-takeuchi-kudo disease. J Neurol Neurosurg Psychiatry 33:671–673CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  1. 1.Department of Neurological SurgeryNihon University School of MedicineItabashi-kuJapan

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