Child's Nervous System

, Volume 27, Issue 12, pp 2177–2181

Desmoplastic infantile astrocytoma: recurrence with malignant transformation into glioblastoma: a case report

  • Ji Hoon Phi
  • Eun Jung Koh
  • Seung-Ki Kim
  • Sung-Hye Park
  • Byung-Kyu Cho
  • Kyu-Chang Wang
Case Report

DOI: 10.1007/s00381-011-1587-6

Cite this article as:
Phi, J.H., Koh, E.J., Kim, SK. et al. Childs Nerv Syst (2011) 27: 2177. doi:10.1007/s00381-011-1587-6

Abstract

Desmoplastic infantile astrocytoma (DIA) is an uncommon brain tumor of early infancy. The tumor is characterized by a lobar location, glial histology, and excellent prognosis after surgical removal. DIA and a similar tumor, desmoplastic infantile ganglioglioma (DIG) have been considered to be benign neoplasms, but the prognosis of DIA and DIG is currently under question as atypical and aggressive clinical features of the tumors have been reported. We encountered a patient who was diagnosed with DIA at the age of 22 months and exhibited tumor recurrence 8 years later. Surgical removal of the recurred tumor revealed that the tumor had transformed to overt glioblastoma. This case demonstrates that DIA is not an absolutely benign tumor and that careful clinical surveillance is needed during the follow-up period.

Keywords

Desmoplastic infantile astrocytoma Malignant transformation Glioblastoma 

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Ji Hoon Phi
    • 1
  • Eun Jung Koh
    • 1
  • Seung-Ki Kim
    • 1
  • Sung-Hye Park
    • 2
  • Byung-Kyu Cho
    • 1
  • Kyu-Chang Wang
    • 1
  1. 1.Division of Pediatric NeurosurgerySeoul National University Children’s HospitalSeoulRepublic of Korea
  2. 2.Department of PathologySeoul National University Children’s Hospital, Seoul National UniversitySeoulRepublic of Korea

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