Child's Nervous System

, Volume 27, Issue 12, pp 2101–2106

Appraisal of the current staging system for residual medulloblastoma by volumetric analysis

  • Dimitris Kombogiorgas
  • Stephanie Puget
  • Nathalie Boddaert
  • Andrew Peet
  • Martin English
  • Kal Natarajan
  • Jacques Grill
  • Dominique Couanet
  • Christian Sainte-Rose
  • Spyros Sgouros
Original Paper

Abstract

Aim

This study aims to investigate the accuracy of the current staging system of childhood medulloblastoma by using volumetric image analysis on immediate post-operative MRI scans.

Material and methods

Tumour volume and maximum cross area of residual medulloblastoma were measured on immediate post-operative MR scans of 37 children operated between 1999 and 2005.

Results

Mean preoperative volume was 32 cm3 (range 4.5–71.9 cm3). Mean post-operative volume was 3.3 cm3 (range 0–23.3 cm3). At mean follow-up of 50.08 months (range 6–129), 15 (40%) patients had died. Cut-off limit for residual post-operative tumour volume employed was maximum cross section of 1.5 cm2, which corresponds to volume of 1.376 cm3; 14 patients (38%) had no residual tumour, 7 patients (19%) had less than 1.5 cm2 and 16 patients (43%) had more than 1.5 cm2 residual tumour in its maximum cross section area. In three patients (8.2%) there was mismatch between the measured maximum cross section area and volume. In particular, in two patients, the cross section areas were more than 1.5 cm2 but the residual tumour volumes were less than 1.376 cm3 (the cross section area overestimated the residual volume) and in one case, the cross section area was less than 1.5 cm2 but the residual tumour volume was more than 1.376 cm3 (the cross section area underestimated the residual volume; difference statistically significant, Fisher's exact test, p < 0.01).

Conclusions

It appears that volumetric measurement of residual medulloblastoma on immediate post-operative MRI scans may further improve the accuracy of staging process.

Keywords

Medulloblastoma Surgery Residual tumour Posterior fossa tumour Staging Image analysis 

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Dimitris Kombogiorgas
    • 1
    • 4
  • Stephanie Puget
    • 2
  • Nathalie Boddaert
    • 2
  • Andrew Peet
    • 1
  • Martin English
    • 1
  • Kal Natarajan
    • 1
  • Jacques Grill
    • 3
  • Dominique Couanet
    • 3
  • Christian Sainte-Rose
    • 2
  • Spyros Sgouros
    • 1
  1. 1.Birmingham Children’s HospitalBirminghamUK
  2. 2.Hôpital Necker-Enfants MaladesParisFrance
  3. 3.Institute Gustave RussyParisFrance
  4. 4.Department of NeurosurgeryBirmingham Children’s HospitalBirminghamUK

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