Child's Nervous System

, Volume 27, Issue 4, pp 517–521 | Cite as

Melanotic medulloblastoma in children

Case-Based Update



We report a case of melanotic medulloblastoma in a child. Reviewing the literature, we discuss the characteristics, therapeutic method, and prognosis of melanotic medulloblastoma in children.

Materials and methods

A 2-year-old girl was admitted with a mass located in the pineal region and presented obstructive hydrocephalus. The mass was subtotally resected through a slit-corpus–fornix approach. Thereafter, intraoperative direct third ventriculostomy was performed. The histopathological diagnosis of the mass suggested melanotic medulloblastoma.


The MRI done at 4 days after surgery showed that the lateral ventricle normalized and the hydrocephalus was resolved. Thereafter, the patient underwent a Gamma Knife. The patient recovered well during the 8-month follow-up.


Melanotic medulloblastoma is a malignant tumor of childhood. It usually occurs at young age and might involve the vermis cerebelli, the fourth ventricle, and the pineal region. Surgery combined with radiotherapy and chemotherapy is recommended for children. But, it still requires observation to determine their long-term prognosis.


Melanotic medulloblastoma Pineal region Child Tumor 


  1. 1.
    Boesel CP, Suhan JP, Sayers MP (1978) Melanotic medulloblastoma. Report of a case with ultrastructural findings. J Neuropathol Exp Neurol 37:531–543PubMedCrossRefGoogle Scholar
  2. 2.
    Dolman CL (1988) Melanotic medulloblastoma: a case report with immunohistochemical and ultrastructural examination. Acta Neuropathol (Berl) 76:528–531CrossRefGoogle Scholar
  3. 3.
    Duinkerke SJ, Slooff JL, Gabreels FJ, Renier WO, Thijssen HO, Biesta JH (1981) Melanotic rhabdomyomedulloblastoma or teratoid tumour of the cerebellar vermis. Clin Neurol Neurosurg 83:29–33PubMedCrossRefGoogle Scholar
  4. 4.
    Erdem E, Zimmerman RA, Haselgrove JC, Bilaniuk LT, Hunter JV (2001) Diffusion-weighted imaging and fluid attenuated inversion recovery imaging in the evaluation of primitive neuroectodermal tumors. Neuroradiology 43:927–933PubMedCrossRefGoogle Scholar
  5. 5.
    Fowler M, Simpson D (1962) A malignant melanin-forming tumour of the cerebellum. J Pathol Bacteriol 84:307–311PubMedCrossRefGoogle Scholar
  6. 6.
    Grill J, Sainte-Rose C, Jouvet A (2005) Treatment of medulloblastoma with postoperative chemotherapy alone: an SFOP prospective trial in young children. Lancet Oncol 6:573–580PubMedCrossRefGoogle Scholar
  7. 7.
    Kapadia SB, Frisman DM, Hitchcock CL (1993) Melanotic neuroectodermal tumor of infancy. Clinicopathological, immunohistochemical, and flow cytometric study. Am J Surg Pathol 17:566–573PubMedCrossRefGoogle Scholar
  8. 8.
    Karkuzhali P, Deiveegan K, Pari K (2005) Melanotic medulloblastoma of cerebellum: a case report. Indian J Pathol Microbiol 48:243–244PubMedGoogle Scholar
  9. 9.
    Kubota KC, Itoh T, Yamada Y (2009) Melanocytic medulloblastoma with ganglioneurocytomatous differentiation: a case report. Neuropathology 29:72–77PubMedCrossRefGoogle Scholar
  10. 10.
    Louis DN, Ohgaki H, Wiestler OD (2007) The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 114:97–109PubMedCrossRefGoogle Scholar
  11. 11.
    MacDonald TJ (2008) Aggressive infantile embryonal tumors. J Child Neurol 23:1195–1204PubMedCrossRefGoogle Scholar
  12. 12.
    Packer RJ, Cogen P, Vezina G, Rorke LB (1999) Medulloblastoma: clinical and biologic aspects. Neuro Oncol 1:232–250PubMedGoogle Scholar
  13. 13.
    Radcliffe J, Packer RJ, Atkins TE (1992) Three- and four-year cognitive outcome in children with noncortical brain tumors treated with whole-brain radiotherapy. Ann Neurol 32:551–554PubMedCrossRefGoogle Scholar
  14. 14.
    Ris MD, Packer R, Goldwein J, Jones-Wallace D (2001) Intellectual outcome after reduced-dose radiation therapy plus adjuvant chemotherapy for medulloblastoma: a Children's Cancer Group study. J Clin Oncol 19:3470–3476PubMedGoogle Scholar
  15. 15.
    Rood BR, Macdonald TJ, Packer RJ (2004) Current treatment of medulloblastoma: recent advances and future challenges. Semin Oncol 31:666–675PubMedCrossRefGoogle Scholar
  16. 16.
    Rubinstein LJ, Northfield DWC (1964) The medulloblastoma and the so-called “arachnoidal cerebellar sarcoma”. Brain 78:379–412CrossRefGoogle Scholar
  17. 17.
    Rutkowski S, Bode U, Deinlein F (2005) Treatment of early childhood medulloblastoma by postoperative chemotherapy alone. N Engl J Med 352:978–986PubMedCrossRefGoogle Scholar
  18. 18.
    Sharma MC, Agarwal M, Suri A, Gaikwad S, Mukhopadhyay P, Sarkar C (2002) A melanotic desmoplastic medulloblastoma: report of a rare case and review of the literature. Brain Tumor Pathol 19:93–96PubMedCrossRefGoogle Scholar
  19. 19.
    Shuangshoti S (1980) Melanotic mucin-producing neuroepithelial neoplasm of mesencephalon with consideration of similar tumours in different locations. J Neurol Neurosurg Psychiatry 43:810–817PubMedCrossRefGoogle Scholar
  20. 20.
    Sung JH, Mastri AR, Segal EL (1973) Melanotic medulloblastoma of the cerebellum. J Neuropathol Exp Neurol 32:437–445PubMedCrossRefGoogle Scholar
  21. 21.
    Zanini C, Mandili G, Pulera F, Morra I (2009) Immunohistochemical and proteomic profile of melanotic medulloblastoma. Pediatr Blood Cancer 52:875–877PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Wen-yan Li
    • 1
  • Lu Ma
    • 2
  • Jian Liu
    • 1
  • Hua Yang
    • 1
  • Qing Mao
    • 2
  1. 1.Department of NeurosurgeryAffiliated Hospital of Guiyang Medical CollegeGuiyangPeople’s Republic of China
  2. 2.Department of Neurosurgery, West China HospitalSichuan UniversityChengduPeople’s Republic of China

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