Child's Nervous System

, Volume 27, Issue 9, pp 1375–1390 | Cite as

Pediatric stroke

Review Paper

Abstract

Introduction

Pediatric stroke, while increasingly recognized among practitioners as a clinically significant, albeit infrequent entity, remains challenging from the viewpoint of clinicians and researchers.

Discussion

Advances in neuroimaging have revealed a higher prevalence of pediatric stroke while also provided a safer method for evaluating the child’s nervous system and vasculature. An understanding of pathogenic mechanisms for pediatric stroke requires a division of ages (perinatal and childhood) and a separation of mechanism (ischemic and hemorrhagic). This article presents a review of the current literature with the recommended divisions of age and mechanism.

Conclusion

Guidelines for treatment, though limited, are also discussed.

Keywords

Pediatric stroke Neonatal stroke Childhood stroke 

References

  1. 1.
    Acciarri N, Galassi E, Giulioni M, Pozzati E, Grasso V, Palandri G, Badaloni F, Zucchelli M, Calbucci F (2009) Cavernous malformations of the central nervous system in the pediatric age group. Pediatr Neurosurg 45:81–104PubMedGoogle Scholar
  2. 2.
    Agrawal N, Johnston SC, Wu YW, Sidney S, Fullerton HJ (2009) Imaging data reveal a higher pediatric stroke incidence than prior US estimates. Stroke 40:3415–3421PubMedGoogle Scholar
  3. 3.
    Al-Jarallah A, Al-Rifai MT, Riela AR, Roach ES (2000) Nontraumatic brain hemorrhage in children: etiology and presentation. J Child Neurol 15:284–289PubMedGoogle Scholar
  4. 4.
    Amlie-Lefond C, Bernard TJ, Sebire G, Friedman NR, Heyer GL, Lerner NB, DeVeber G, Fullerton HJ (2009) Predictors of cerebral arteriopathy in children with arterial ischemic stroke: results of the International Pediatric Stroke Study. Circulation 119:1417–1423PubMedGoogle Scholar
  5. 5.
    Amlie-Lefond C, Sebire G, Fullerton HJ (2008) Recent developments in childhood arterial ischaemic stroke. Lancet Neurol 7:425–435PubMedGoogle Scholar
  6. 6.
    Andrew M, Paes B, Johnston M (1990) Development of the hemostatic system in the neonate and young infant. Am J Pediatr Hematol Oncol 12:95–104PubMedGoogle Scholar
  7. 7.
    Andrew M, Paes B, Milner R, Johnston M, Mitchell L, Tollefsen DM, Powers P (1987) Development of the human coagulation system in the full-term infant. Blood 70:165–172PubMedGoogle Scholar
  8. 8.
    Andrew M, Vegh P, Johnston M, Bowker J, Ofosu F, Mitchell L (1992) Maturation of the hemostatic system during childhood. Blood 80:1998–2005PubMedGoogle Scholar
  9. 9.
    Armstrong-Wells J, Johnston SC, Wu YW, Sidney S, Fullerton HJ (2009) Prevalence and predictors of perinatal hemorrhagic stroke: results from the Kaiser pediatric stroke study. Pediatrics 123:823–828PubMedGoogle Scholar
  10. 10.
    Barnes C, Newall F, Furmedge J, Mackay M, Monagle P (2004) Cerebral sinus venous thrombosis in children. J Paediatr Child Health 40:53–55PubMedGoogle Scholar
  11. 11.
    Barnes C, Newall F, Harvey AS, Monagle P (2004) Thrombophilia interpretation in childhood stroke: a cautionary tale. J Child Neurol 19:218–219PubMedGoogle Scholar
  12. 12.
    Belostotsky VM, Shah V, Dillon MJ (2002) Clinical features in 17 paediatric patients with Wegener granulomatosis. Pediatr Nephrol 17:754–761PubMedGoogle Scholar
  13. 13.
    Benders MJ, Groenendaal F, De Vries LS (2009) Preterm arterial ischemic stroke. Semin Fetal Neonatal Med 14:272–277PubMedGoogle Scholar
  14. 14.
    Benseler S, Schneider R (2004) Central nervous system vasculitis in children. Curr Opin Rheumatol 16:43–50PubMedGoogle Scholar
  15. 15.
    Berman JL, Kashii S, Trachtman MS, Burde RM (1990) Optic neuropathy and central nervous system disease secondary to Sjogren’s syndrome in a child. Ophthalmology 97:1606–1609PubMedGoogle Scholar
  16. 16.
    Bernard TJ, Goldenberg NA (2008) Pediatric arterial ischemic stroke. Pediatr Clin N Am 55:323–338, viiiGoogle Scholar
  17. 17.
    Bernard TJ, Goldenberg NA, Armstrong-Wells J, Amlie-Lefond C, Fullerton HJ (2008) Treatment of childhood arterial ischemic stroke. Ann Neurol 63:679–696PubMedGoogle Scholar
  18. 18.
    Boardman JP, Ganesan V, Rutherford MA, Saunders DE, Mercuri E, Cowan F (2005) Magnetic resonance image correlates of hemiparesis after neonatal and childhood middle cerebral artery stroke. Pediatrics 115:321–326PubMedGoogle Scholar
  19. 19.
    Bonduel M, Sciuccati G, Hepner M, Torres AF, Pieroni G, Frontroth JP (1999) Prethrombotic disorders in children with arterial ischemic stroke and sinovenous thrombosis. Arch Neurol 56:967–971PubMedGoogle Scholar
  20. 20.
    Bousser MG (1997) Aspirin or heparin immediately after a stroke? Lancet 349:1564–1565PubMedGoogle Scholar
  21. 21.
    Brenner DJ, Hall EJ (2007) Computed tomography—an increasing source of radiation exposure. N Engl J Med 357:2277–2284PubMedGoogle Scholar
  22. 22.
    Brown RD Jr, Flemming KD, Meyer FB, Cloft HJ, Pollock BE, Link ML (2005) Natural history, evaluation, and management of intracranial vascular malformations. Mayo Clin Proc 80:269–281PubMedGoogle Scholar
  23. 23.
    Burrows PE, Lasjaunias PL, Ter Brugge KG, Flodmark O (1987) Urgent and emergent embolization of lesions of the head and neck in children: indications and results. Pediatrics 80:386–394PubMedGoogle Scholar
  24. 24.
    Cakmak S, Derex L, Berruyer M, Nighoghossian N, Philippeau F, Adeleine P, Hermier M, Froment JC, Trouillas P (2003) Cerebral venous thrombosis: clinical outcome and systematic screening of prothrombotic factors. Neurology 60:1175–1178PubMedGoogle Scholar
  25. 25.
    Carvalho KS, Garg BP (2002) Arterial strokes in children. Neurol Clin 20:1079–1100, viiPubMedGoogle Scholar
  26. 26.
    Cheong JL, Cowan FM (2009) Neonatal arterial ischaemic stroke: obstetric issues. Semin Fetal Neonatal Med 14:267–271PubMedGoogle Scholar
  27. 27.
    Cho DY, Chen TC, Lee HC (2003) Ultra-early decompressive craniectomy for malignant middle cerebral artery infarction. Surg Neurol 60:227–232, discussion 232–223PubMedGoogle Scholar
  28. 28.
    Ciccone A, Melis M (2003) Ischemic stroke risk in oral contraceptive users. Stroke 34:e231, author reply e231PubMedGoogle Scholar
  29. 29.
    Cnossen MH, van Ommen CH, Appel IM (2009) Etiology and treatment of perinatal stroke; a role for prothrombotic coagulation factors? Semin Fetal Neonatal Med 14:311–317PubMedGoogle Scholar
  30. 30.
    Consales A, Piatelli G, Ravegnani M, Pavanello M, Striano P, Zoli ML, Capra V, Rossi A, Garre ML, Calevo MG, Cama A (2010) Treatment and outcome of children with cerebral cavernomas: a survey on 32 patients. Neurol Sci 31:117–123PubMedGoogle Scholar
  31. 31.
    Crisostomo EA, Leaton E, Rosenblum EL (1986) Features of intracranial aneurysms in infants and report of a case. Dev Med Child Neurol 28:68–72PubMedGoogle Scholar
  32. 32.
    Danchaivijitr N, Cox TC, Saunders DE, Ganesan V (2006) Evolution of cerebral arteriopathies in childhood arterial ischemic stroke. Ann Neurol 59:620–626PubMedGoogle Scholar
  33. 33.
    Danchaivijitr N, Miravet E, Saunders DE, Cox T, Ganesan V (2006) Post-varicella intracranial haemorrhage in a child. Dev Med Child Neurol 48:139–142PubMedGoogle Scholar
  34. 34.
    de Ribaupierre S, Rilliet B, Cotting J, Regli L (2008) A 10-year experience in paediatric spontaneous cerebral hemorrhage: which children with headache need more than a clinical examination? Swiss Med Wkly 138:59–69PubMedGoogle Scholar
  35. 35.
    Deitcher SR, Gajjar A, Kun L, Heideman RL (2004) Clinically evident venous thromboembolic events in children with brain tumors. J Pediatr 145:848–850PubMedGoogle Scholar
  36. 36.
    Del Curling O Jr, Kelly DL Jr, Elster AD, Craven TE (1991) An analysis of the natural history of cavernous angiomas. J Neurosurg 75:702–708PubMedGoogle Scholar
  37. 37.
    deVeber G, Andrew M, Adams C, Bjornson B, Booth F, Buckley DJ, Camfield CS, David M, Humphreys P, Langevin P, MacDonald EA, Gillett J, Meaney B, Shevell M, Sinclair DB, Yager J (2001) Cerebral sinovenous thrombosis in children. N Engl J Med 345:417–423PubMedGoogle Scholar
  38. 38.
    DeVeber G, Kirkham F (2008) Guidelines for the treatment and prevention of stroke in children. Lancet Neurol 7:983–985PubMedGoogle Scholar
  39. 39.
    deVeber GA, MacGregor D, Curtis R, Mayank S (2000) Neurologic outcome in survivors of childhood arterial ischemic stroke and sinovenous thrombosis. J Child Neurol 15:316–324PubMedGoogle Scholar
  40. 40.
    Doyle KP, Simon RP, Stenzel-Poore MP (2008) Mechanisms of ischemic brain damage. Neuropharmacology 55:310–318PubMedGoogle Scholar
  41. 41.
    Edlow JA, Malek AM, Ogilvy CS (2008) Aneurysmal subarachnoid hemorrhage: update for emergency physicians. J Emerg Med 34:237–251PubMedGoogle Scholar
  42. 42.
    Ferriero DM (2004) Neonatal brain injury. N Engl J Med 351:1985–1995PubMedGoogle Scholar
  43. 43.
    Fitzgerald KC, Williams LS, Garg BP, Golomb MR (2007) Epilepsy in children with delayed presentation of perinatal stroke. J Child Neurol 22:1274–1280PubMedGoogle Scholar
  44. 44.
    Frisoni GB, Anzola GP (1991) Vertebrobasilar ischemia after neck motion. Stroke 22:1452–1460PubMedGoogle Scholar
  45. 45.
    Fullerton HJ, Achrol AS, Johnston SC, McCulloch CE, Higashida RT, Lawton MT, Sidney S, Young WL (2005) Long-term hemorrhage risk in children versus adults with brain arteriovenous malformations. Stroke 36:2099–2104PubMedGoogle Scholar
  46. 46.
    Furie B, Furie BC (2008) Mechanisms of thrombus formation. N Engl J Med 359:938–949PubMedGoogle Scholar
  47. 47.
    Gabis LV, Yangala R, Lenn NJ (2002) Time lag to diagnosis of stroke in children. Pediatrics 110:924–928PubMedGoogle Scholar
  48. 48.
    Gailloud P (2005) Endovascular treatment of cerebral arteriovenous malformations. Tech Vasc Interv Radiol 8:118–128PubMedGoogle Scholar
  49. 49.
    Golomb MR (2009) Outcomes of perinatal arterial ischemic stroke and cerebral sinovenous thrombosis. Semin Fetal Neonatal Med 14:318–322PubMedGoogle Scholar
  50. 50.
    Golomb MR, Fullerton HJ, Nowak-Gottl U, Deveber G (2009) Male predominance in childhood ischemic stroke: findings from the international pediatric stroke study. Stroke 40:52–57PubMedGoogle Scholar
  51. 51.
    Golomb MR, Garg BP, Carvalho KS, Johnson CS, Williams LS (2007) Perinatal stroke and the risk of developing childhood epilepsy. J Pediatr 151:409–413, 413 e401-402PubMedGoogle Scholar
  52. 52.
    Govaert P (2009) Prenatal stroke. Semin Fetal Neonatal Med 14:250–266PubMedGoogle Scholar
  53. 53.
    Govaert P, Smith L, Dudink J (2009) Diagnostic management of neonatal stroke. Semin Fetal Neonatal Med 14:323–328PubMedGoogle Scholar
  54. 54.
    Graf WD, Milstein JM, Sherry DD (1993) Stroke and mixed connective tissue disease. J Child Neurol 8:256–259PubMedGoogle Scholar
  55. 55.
    Groenendaal F, de Vries LS (2005) Watershed infarcts in the full term neonatal brain. Arch Dis Child Fetal Neonatal Ed 90:F488PubMedGoogle Scholar
  56. 56.
    Gupta R, Connolly ES, Mayer S, Elkind MS (2004) Hemicraniectomy for massive middle cerebral artery territory infarction: a systematic review. Stroke 35:539–543PubMedGoogle Scholar
  57. 57.
    Hartman AL, Lunney KM, Serena JE (2009) Pediatric stroke: do clinical factors predict delays in presentation? J Pediatr 154:727–732PubMedGoogle Scholar
  58. 58.
    Hey E (1999) Effect of maternal anticonvulsant treatment on neonatal blood coagulation. Arch Dis Child Fetal Neonatal Ed 81:F208–F210PubMedGoogle Scholar
  59. 59.
    Heyer GL, Dowling MM, Licht DJ, Tay SK, Morel K, Garzon MC, Meyers P (2008) The cerebral vasculopathy of PHACES syndrome. Stroke 39:308–316PubMedGoogle Scholar
  60. 60.
    Hossmann KA (2006) Pathophysiology and therapy of experimental stroke. Cell Mol Neurobiol 26:1057–1083PubMedGoogle Scholar
  61. 61.
    Howe AM, Oakes DJ, Woodman PD, Webster WS (1999) Prothrombin and PIVKA-II levels in cord blood from newborn exposed to anticonvulsants during pregnancy. Epilepsia 40:980–984PubMedGoogle Scholar
  62. 62.
    Humphreys RP, Hoffman HJ, Drake JM, Rutka JT (1996) Choices in the 1990s for the management of pediatric cerebral arteriovenous malformations. Pediatr Neurosurg 25:277–285PubMedGoogle Scholar
  63. 63.
    Jordan LC, Johnston SC, Wu YW, Sidney S, Fullerton HJ (2009) The importance of cerebral aneurysms in childhood hemorrhagic stroke: a population-based study. Stroke 40:400–405PubMedGoogle Scholar
  64. 64.
    Jordan LC, Rafay MF, Smith SE, Askalan R, Zamel KM, deVeber G, Ashwal S (2010) Antithrombotic treatment in neonatal cerebral sinovenous thrombosis: results of the International Pediatric Stroke Study. J Pediatr 156:704–710PubMedGoogle Scholar
  65. 65.
    Kasahara E, Murayama T, Yamane C (1996) Giant cerebral arterial aneurysm in an infant: report of a case and review of 42 previous cases in infants with cerebral arterial aneurysm. Acta Paediatr Jpn 38:684–688PubMedGoogle Scholar
  66. 66.
    Kassell NF, Torner JC, Jane JA, Haley EC Jr, Adams HP (1990) The International Cooperative Study on the Timing of Aneurysm Surgery. Part 2: Surgical results. J Neurosurg 73:37–47PubMedGoogle Scholar
  67. 67.
    Kaufmann P, Shungu DC, Sano MC, Jhung S, Engelstad K, Mitsis E, Mao X, Shanske S, Hirano M, DiMauro S, De Vivo DC (2004) Cerebral lactic acidosis correlates with neurological impairment in MELAS. Neurology 62:1297–1302PubMedGoogle Scholar
  68. 68.
    Kenet G, Lutkhoff LK, Albisetti M, Bernard T, Bonduel M, Brandao L, Chabrier S, Chan A, deVeber G, Fiedler B, Fullerton HJ, Goldenberg NA, Grabowski E, Gunther G, Heller C, Holzhauer S, Iorio A, Journeycake J, Junker R, Kirkham FJ, Kurnik K, Lynch JK, Male C, Manco-Johnson M, Mesters R, Monagle P, van Ommen CH, Raffini L, Rostasy K, Simioni P, Strater RD, Young G, Nowak-Gottl U (2010) Impact of thrombophilia on risk of arterial ischemic stroke or cerebral sinovenous thrombosis in neonates and children: a systematic review and meta-analysis of observational studies. Circulation 121:1838–1847PubMedGoogle Scholar
  69. 69.
    Kenet G, Sadetzki S, Murad H, Martinowitz U, Rosenberg N, Gitel S, Rechavi G, Inbal A (2000) Factor V Leiden and antiphospholipid antibodies are significant risk factors for ischemic stroke in children. Stroke 31:1283–1288PubMedGoogle Scholar
  70. 70.
    Kirton A, deVeber G (2009) Advances in perinatal ischemic stroke. Pediatr Neurol 40:205–214PubMedGoogle Scholar
  71. 71.
    Kirton A, Deveber G, Pontigon AM, Macgregor D, Shroff M (2008) Presumed perinatal ischemic stroke: vascular classification predicts outcomes. Ann Neurol 63:436–443PubMedGoogle Scholar
  72. 72.
    Kirton A, Shroff M, Visvanathan T, deVeber G (2007) Quantified corticospinal tract diffusion restriction predicts neonatal stroke outcome. Stroke 38:974–980PubMedGoogle Scholar
  73. 73.
    Kirton A, Wei X (2010) Teaching neuroimages: confirmation of prenatal periventricular venous infarction with susceptibility-weighted MRI. Neurology 74:e48PubMedGoogle Scholar
  74. 74.
    Kirton A, Westmacott R, deVeber G (2007) Pediatric stroke: rehabilitation of focal injury in the developing brain. NeuroRehabilitation 22:371–382PubMedGoogle Scholar
  75. 75.
    Klein I, Iung B, Labreuche J, Hess A, Wolff M, Messika-Zeitoun D, Lavallee P, Laissy JP, Leport C, Duval X (2009) Cerebral microbleeds are frequent in infective endocarditis: a case–control study. Stroke 40:3461–3465PubMedGoogle Scholar
  76. 76.
    Krieger DW, De Georgia MA, Abou-Chebl A, Andrefsky JC, Sila CA, Katzan IL, Mayberg MR, Furlan AJ (2001) Cooling for acute ischemic brain damage (cool aid): an open pilot study of induced hypothermia in acute ischemic stroke. Stroke 32:1847–1854PubMedGoogle Scholar
  77. 77.
    Lanthier S, Carmant L, David M, Larbrisseau A, de Veber G (2000) Stroke in children: the coexistence of multiple risk factors predicts poor outcome. Neurology 54:371–378PubMedGoogle Scholar
  78. 78.
    Lasjaunias P, Wuppalapati S, Alvarez H, Rodesch G, Ozanne A (2005) Intracranial aneurysms in children aged under 15 years: review of 59 consecutive children with 75 aneurysms. Childs Nerv Syst 21:437–450PubMedGoogle Scholar
  79. 79.
    Lee JW, Kim DS, Shim KW, Chang JH, Huh SK, Park YG, Choi JU (2008) Management of intracranial cavernous malformation in pediatric patients. Childs Nerv Syst 24:321–327PubMedGoogle Scholar
  80. 80.
    Lequin MH, Dudink J, Tong KA, Obenaus A (2009) Magnetic resonance imaging in neonatal stroke. Semin Fetal Neonatal Med 14:299–310PubMedGoogle Scholar
  81. 81.
    Levy EI, Niranjan A, Thompson TP, Scarrow AM, Kondziolka D, Flickinger JC, Lunsford LD (2000) Radiosurgery for childhood intracranial arteriovenous malformations. Neurosurgery 47:834–841, discussion 841–832PubMedGoogle Scholar
  82. 82.
    Lin CL, Loh JK, Kwan AL, Howng SL (1999) Spontaneous intracerebral hemorrhage in children. Kaohsiung J Med Sci 15:146–151PubMedGoogle Scholar
  83. 83.
    Liu M, Dziennis S, Hurn PD, Alkayed NJ (2009) Mechanisms of gender-linked ischemic brain injury. Restor Neurol Neurosci 27:163–179PubMedGoogle Scholar
  84. 84.
    Livingston JH, Brown JK (1986) Intracerebral haemorrhage after the neonatal period. Arch Dis Child 61:538–544PubMedGoogle Scholar
  85. 85.
    Lo W, Zamel K, Ponnappa K, Allen A, Chisolm D, Tang M, Kerlin B, Yeates KO (2008) The cost of pediatric stroke care and rehabilitation. Stroke 39:161–165PubMedGoogle Scholar
  86. 86.
    Loeffler JS, Rossitch E Jr, Siddon R, Moore MR, Rockoff MA, Alexander E 3rd (1990) Role of stereotactic radiosurgery with a linear accelerator in treatment of intracranial arteriovenous malformations and tumors in children. Pediatrics 85:774–782PubMedGoogle Scholar
  87. 87.
    Looney CB, Smith JK, Merck LH, Wolfe HM, Chescheir NC, Hamer RM, Gilmore JH (2007) Intracranial hemorrhage in asymptomatic neonates: prevalence on MR images and relationship to obstetric and neonatal risk factors. Radiology 242:535–541PubMedGoogle Scholar
  88. 88.
    Lynch JK (2009) Epidemiology and classification of perinatal stroke. Semin Fetal Neonatal Med 14:245–249PubMedGoogle Scholar
  89. 89.
    Malik S, Cohen BH, Robinson J, Fried A, Sila CA (1992) Progressive vision loss. A rare manifestation of familial cavernous angiomas. Arch Neurol 49:170–173PubMedGoogle Scholar
  90. 90.
    Mallick AA, Sharples PM, Calvert SE, Jones RW, Leary M, Lux AL, O’Callaghan FJ, Osborne JP, Patel JS, Prendiville AT, Renowden S, Jardine PE (2009) Cerebral venous sinus thrombosis: a case series including thrombolysis. Arch Dis Child 94:790–794PubMedGoogle Scholar
  91. 91.
    Mayer SA, Brun NC, Begtrup K, Broderick J, Davis S, Diringer MN, Skolnick BE, Steiner T (2005) Recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med 352:777–785PubMedGoogle Scholar
  92. 92.
    McGlennan C, Ganesan V (2008) Delays in investigation and management of acute arterial ischaemic stroke in children. Dev Med Child Neurol 50:537–540PubMedGoogle Scholar
  93. 93.
    McQuillen PS, Miller SP (2010) Congenital heart disease and brain development. Ann N Y Acad Sci 1184:68–86PubMedGoogle Scholar
  94. 94.
    Menovsky T, van Overbeeke JJ (1997) Cerebral arteriovenous malformations in childhood: state of the art with special reference to treatment. Eur J Pediatr 156:741–746PubMedGoogle Scholar
  95. 95.
    Mergenthaler P, Dirnagl U, Meisel A (2004) Pathophysiology of stroke: lessons from animal models. Metab Brain Dis 19:151–167PubMedGoogle Scholar
  96. 96.
    Meyer-Heim AD, Boltshauser E (2003) Spontaneous intracranial haemorrhage in children: aetiology, presentation and outcome. Brain Dev 25:416–421PubMedGoogle Scholar
  97. 97.
    Moharir MD, Shroff M, Stephens D, Pontigon AM, Chan A, MacGregor D, Mikulis D, Adams M, deVeber G (2010) Anticoagulants in pediatric cerebral sinovenous thrombosis: a safety and outcome study. Ann Neurol 67:590–599PubMedGoogle Scholar
  98. 98.
    Monagle P, Barnes C, Ignjatovic V, Furmedge J, Newall F, Chan A, De Rosa L, Hamilton S, Ragg P, Robinson S, Auldist A, Crock C, Roy N, Rowlands S (2006) Developmental haemostasis. Impact for clinical haemostasis laboratories. Thromb Haemost 95:362–372PubMedGoogle Scholar
  99. 99.
    Monagle P, Chalmers E, Chan A, DeVeber G, Kirkham F, Massicotte P, Michelson AD (2008) Antithrombotic therapy in neonates and children: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th edition). Chest 133:887S–968SPubMedGoogle Scholar
  100. 100.
    Morales E, Pineda C, Martinez-Lavin M (1991) Takayasu’s arteritis in children. J Rheumatol 18:1081–1084PubMedGoogle Scholar
  101. 101.
    Morfin-Maciel B, Medina A, Espinosa Rosales F, Berron R, Huerta Lopez J (2002) Central nervous system involvement in a child with polyarteritis nodosa and severe atopic dermatitis. Rev Alerg Méx 49:189–195PubMedGoogle Scholar
  102. 102.
    Nelson KB (2007) Perinatal ischemic stroke. Stroke 38:742–745PubMedGoogle Scholar
  103. 103.
    Newall F, Johnston L, Ignjatovic V, Monagle P (2009) Unfractionated heparin therapy in infants and children. Pediatrics 123:e510–e518PubMedGoogle Scholar
  104. 104.
    Nolan JP, Morley PT, Vanden Hoek TL, Hickey RW, Kloeck WG, Billi J, Bottiger BW, Okada K, Reyes C, Shuster M, Steen PA, Weil MH, Wenzel V, Carli P, Atkins D (2003) Therapeutic hypothermia after cardiac arrest: an advisory statement by the advanced life support task force of the International Liaison Committee on Resuscitation. Circulation 108:118–121PubMedGoogle Scholar
  105. 105.
    Ozduman K, Pober BR, Barnes P, Copel JA, Ogle EA, Duncan CC, Ment LR (2004) Fetal stroke. Pediatr Neurol 30:151–162PubMedGoogle Scholar
  106. 106.
    Perkins E, Stephens J, Xiang H, Lo W (2009) The cost of pediatric stroke acute care in the United States. Stroke 40:2820–2827PubMedGoogle Scholar
  107. 107.
    Punt J (2004) Surgical management of paediatric stroke. Pediatr Radiol 34:16–23PubMedGoogle Scholar
  108. 108.
    Rafay MF, Pontigon AM, Chiang J, Adams M, Jarvis DA, Silver F, Macgregor D, Deveber GA (2009) Delay to diagnosis in acute pediatric arterial ischemic stroke. Stroke 40:58–64PubMedGoogle Scholar
  109. 109.
    Raju TN, Nelson KB, Ferriero D, Lynch JK (2007) Ischemic perinatal stroke: summary of a workshop sponsored by the National Institute of Child Health and Human Development and the National Institute of Neurological Disorders and Stroke. Pediatrics 120:609–616PubMedGoogle Scholar
  110. 110.
    Ramaswamy V, Mehta V, Bauman M, Richer L, Massicotte P, Yager JY (2008) Decompressive hemicraniectomy in children with severe ischemic stroke and life-threatening cerebral edema. J Child Neurol 23:889–894PubMedGoogle Scholar
  111. 111.
    Ramaswamy V, Miller SP, Barkovich AJ, Partridge JC, Ferriero DM (2004) Perinatal stroke in term infants with neonatal encephalopathy. Neurology 62:2088–2091PubMedGoogle Scholar
  112. 112.
    Ramenghi LA, Govaert P, Fumagalli M, Bassi L, Mosca F (2009) Neonatal cerebral sinovenous thrombosis. Semin Fetal Neonatal Med 14:278–283PubMedGoogle Scholar
  113. 113.
    Roach ES, Golomb MR, Adams R, Biller J, Daniels S, Deveber G, Ferriero D, Jones BV, Kirkham FJ, Scott RM, Smith ER (2008) Management of stroke in infants and children: a scientific statement from a Special Writing Group of the American Heart Association Stroke Council and the Council on Cardiovascular Disease in the Young. Stroke 39:2644–2691PubMedGoogle Scholar
  114. 114.
    Sachs BP, Acker D, Tuomala R, Brown E (1987) The incidence of symptomatic intracranial hemorrhage in term appropriate-for-gestation-age infants. Clin Pediatr Phila 26:355–358PubMedGoogle Scholar
  115. 115.
    Sames TA, Storrow AB, Finkelstein JA, Magoon MR (1996) Sensitivity of new-generation computed tomography in subarachnoid hemorrhage. Acad Emerg Med 3:16–20PubMedGoogle Scholar
  116. 116.
    Santhosh K, Kesavadas C, Thomas B, Gupta AK, Thamburaj K, Kapilamoorthy TR (2009) Susceptibility weighted imaging: a new tool in magnetic resonance imaging of stroke. Clin Radiol 64:74–83PubMedGoogle Scholar
  117. 117.
    Schoenberg BS, Mellinger JF, Schoenberg DG (1978) Moyamoya disease in children. South Med J 71:237–241PubMedGoogle Scholar
  118. 118.
    Sebire G, Tabarki B, Saunders DE, Leroy I, Liesner R, Saint-Martin C, Husson B, Williams AN, Wade A, Kirkham FJ (2005) Cerebral venous sinus thrombosis in children: risk factors, presentation, diagnosis and outcome. Brain 128:477–489PubMedGoogle Scholar
  119. 119.
    Shankaran S, Laptook AR, Ehrenkranz RA, Tyson JE, McDonald SA, Donovan EF, Fanaroff AA, Poole WK, Wright LL, Higgins RD, Finer NN, Carlo WA, Duara S, Oh W, Cotten CM, Stevenson DK, Stoll BJ, Lemons JA, Guillet R, Jobe AH (2005) Whole-body hypothermia for neonates with hypoxic–ischemic encephalopathy. N Engl J Med 353:1574–1584PubMedGoogle Scholar
  120. 120.
    Shin M (2002) Gamma knife radiosurgery for arteriovenous malformations: anatomy, techniques, and avoidance. No Shinkei Geka 30:703–714PubMedGoogle Scholar
  121. 121.
    Sidman R, Connolly E, Lemke T (1996) Subarachnoid hemorrhage diagnosis: lumbar puncture is still needed when the computed tomography scan is normal. Acad Emerg Med 3:827–831PubMedGoogle Scholar
  122. 122.
    Simard JM, Garcia-Bengochea F, Ballinger WE Jr, Mickle JP, Quisling RG (1986) Cavernous angioma: a review of 126 collected and 12 new clinical cases. Neurosurgery 18:162–172PubMedGoogle Scholar
  123. 123.
    Sirvente J, Enjolras O, Wassef M, Tournier-Lasserve E, Labauge P (2009) Frequency and phenotypes of cutaneous vascular malformations in a consecutive series of 417 patients with familial cerebral cavernous malformations. J Eur Acad Dermatol Venereol 23:1066–1072PubMedGoogle Scholar
  124. 124.
    Smith ER, Butler WE, Ogilvy CS (2002) Surgical approaches to vascular anomalies of the child’s brain. Curr Opin Neurol 15:165–171PubMedGoogle Scholar
  125. 125.
    Smyth MD, Sneed PK, Ciricillo SF, Edwards MS, Wara WM, Larson DA, Lawton MT, Gutin PH, McDermott MW (2002) Stereotactic radiosurgery for pediatric intracranial arteriovenous malformations: the University of California at San Francisco experience. J Neurosurg 97:48–55PubMedGoogle Scholar
  126. 126.
    So Y, Lee HY, Kim SK, Lee JS, Wang KC, Cho BK, Kang E, Lee DS (2005) Prediction of the clinical outcome of pediatric moyamoya disease with postoperative basal/acetazolamide stress brain perfusion SPECT after revascularization surgery. Stroke 36:1485–1489PubMedGoogle Scholar
  127. 127.
    Srinivasan J, Miller SP, Phan TG, Mackay MT (2009) Delayed recognition of initial stroke in children: need for increased awareness. Pediatrics 124:e227–e234PubMedGoogle Scholar
  128. 128.
    Strater R, Kurnik K, Heller C, Schobess R, Luigs P, Nowak-Gottl U (2001) Aspirin versus low-dose low-molecular-weight heparin: antithrombotic therapy in pediatric ischemic stroke patients: a prospective follow-up study. Stroke 32:2554–2558PubMedGoogle Scholar
  129. 129.
    Takanashi J, Barkovich AJ, Ferriero DM, Suzuki H, Kohno Y (2003) Widening spectrum of congenital hemiplegia: periventricular venous infarction in term neonates. Neurology 61:531–533PubMedGoogle Scholar
  130. 130.
    Tan MA, Armstrong D, MacGregor DL, Kirton A (2009) Late complications of vertebral artery dissection in children: pseudoaneurysm, thrombosis, and recurrent stroke. J Child Neurol 24:354–360PubMedGoogle Scholar
  131. 131.
    Vahedi K, Hofmeijer J, Juettler E, Vicaut E, George B, Algra A, Amelink GJ, Schmiedeck P, Schwab S, Rothwell PM, Bousser MG, van der Worp HB, Hacke W (2007) Early decompressive surgery in malignant infarction of the middle cerebral artery: a pooled analysis of three randomised controlled trials. Lancet Neurol 6:215–222PubMedGoogle Scholar
  132. 132.
    Ventureyra EC, Higgins MJ (1994) Traumatic intracranial aneurysms in childhood and adolescence. Case reports and review of the literature. Childs Nerv Syst 10:361–379PubMedGoogle Scholar
  133. 133.
    Ville Y, Jenkins E, Shearer MJ, Hemley H, Vasey DP, Layton M, Nicolaides KH (1993) Fetal intraventricular haemorrhage and maternal warfarin. Lancet 341:1211PubMedGoogle Scholar
  134. 134.
    von Scheven E, Lee C, Berg BO (1998) Pediatric Wegener’s granulomatosis complicated by central nervous system vasculitis. Pediatr Neurol 19:317–319Google Scholar
  135. 135.
    Wasay M, Dai AI, Ansari M, Shaikh Z, Roach ES (2008) Cerebral venous sinus thrombosis in children: a multicenter cohort from the United States. J Child Neurol 23:26–31PubMedGoogle Scholar
  136. 136.
    Wojtacha M, Bazowski P, Mandera M, Krawczyk I, Rudnik A (2001) Cerebral aneurysms in childhood. Childs Nerv Syst 17:37–41PubMedGoogle Scholar
  137. 137.
    Wu YW, Hamrick SE, Miller SP, Haward MF, Lai MC, Callen PW, Barkovich AJ, Ferriero DM (2003) Intraventricular hemorrhage in term neonates caused by sinovenous thrombosis. Ann Neurol 54:123–126PubMedGoogle Scholar
  138. 138.
    Yenari M, Kitagawa K, Lyden P, Perez-Pinzon M (2008) Metabolic downregulation: a key to successful neuroprotection? Stroke 39:2910–2917PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Javier F. Cárdenas
    • 1
  • Jong M. Rho
    • 2
  • Adam Kirton
    • 2
  1. 1.Division of Pediatric NeurologyBarrow Neurological Institute, St. Joseph’s Hospital & Medical CenterPhoenixUSA
  2. 2.Division of Pediatric Neurology, Alberta Children’s HospitalUniversity of CalgaryCalgaryCanada

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