Child's Nervous System

, Volume 27, Issue 1, pp 11–18 | Cite as

DTI assessment of the brainstem white matter tracts in pediatric BSG before and after therapy

A report from the pediatric brain tumor consortium
  • Sanjay P. Prabhu
  • Sarah Ng
  • Sridhar Vajapeyam
  • Mark W. Kieran
  • Ian F. Pollack
  • Russell Geyer
  • Daphne Haas-Kogan
  • James M. Boyett
  • Larry Kun
  • Tina Young Poussaint
Brief Communication



To assess changes in apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values in brainstem gliomas (BSG) in children and to observe the temporal evolution of changes in the white matter tracts following therapy using diffusion tensor imaging (DTI) analysis.


Serial ADC and FA measurements were obtained in three patients with newly diagnosed BSG on two approved treatment protocols. Values were compared with a set of normative ADC, FA, and eigenvalues of age-matched children of the corticospinal, transverse pontine and medial lemniscal tracts. Fiber tracking of the tracts coursing through the brainstem was performed using standard diffusion tractography analysis.


We found increased ADC values within tumor at baseline compared to age-matched controls, with subsequent drop following treatment and subsequent increase with recurrence. Correspondingly, FA values were reduced at presentation, but transiently recovered during the phase of tumor response to treatment, and finally decreased significantly during tumor progression. These changes were concordant with the tractography analysis of white matter tracts in the brainstem. Based on these results, we suggest that initial changes in ADC and FA values reflects tract infiltration by tumor, but not complete disruption, whereas tumor progression results in complete loss of anisotropy possibly due to tract disruption.


Serial changes in ADC and FA values and tractography data in pediatric BSG suggest initial tumor infiltration, with transient improvement on treatment and subsequent loss of tract anisotropy during tumor progression. This technique may have potential use in assessing response to treatment regimens for pediatric BSG.


MRI Diffusion tensor imaging Brainstem glioma Pediatrics 


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Sanjay P. Prabhu
    • 1
  • Sarah Ng
    • 1
  • Sridhar Vajapeyam
    • 1
  • Mark W. Kieran
    • 2
  • Ian F. Pollack
    • 3
  • Russell Geyer
    • 4
  • Daphne Haas-Kogan
    • 5
  • James M. Boyett
    • 6
  • Larry Kun
    • 7
  • Tina Young Poussaint
    • 1
  1. 1.Department of RadiologyHarvard Medical School, Children’s Hospital BostonBostonUSA
  2. 2.Pediatric Neuro-OncologyDana Farber Cancer CenterBostonUSA
  3. 3.Department of NeurosurgeryChildren’s Hospital of PittsburghPittsburghUSA
  4. 4.Department of Hematology/OncologySeattle Children’s HospitalSeattleUSA
  5. 5.Department of Radiation OncologyUniversity of California at San FranciscoSan FranciscoUSA
  6. 6.Department of BiostatisticsSt. Jude Children’s Research HospitalMemphisUSA
  7. 7.Department of Radiological SciencesSt. Jude Children’s Research HospitalMemphisUSA

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