Skip to main content
SpringerLink
Log in

MGMT promoter methylation in pediatric high-grade gliomas

  • Letter to the Editor
  • Published:
Child's Nervous System Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Buttarelli FR, Massimino M, Antonelli M, Lauriola L, Nozza P, Donofrio V, Arcella A, Oliva MA, Di Rocco C, Giangaspero F (2010) Evaluation status and prognostic significance of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation in pediatric high grade gliomas. Childs Nerv Syst 26:1051–1056

    Article  PubMed  Google Scholar 

  2. Srivastava A, Jain A, Jha P, Suri V, Sharma MC, Mallick S, Puri T, Gupta DK, Gupta A, Sarkar C (2010) MGMT gene promoter methylation in pediatric glioblastomas. Childs Nerv Syst. doi:10.1007/s00381-010-1214-y

    Google Scholar 

  3. Donson AM, Addo-Yobo SO, Handler MH, Gore L, Foreman NK (2007) MGMT promoter methylation correlates with survival benefit and sensitivity to temozolomide in pediatric glioblastoma. Pediatr Blood Cancer 48:403–407

    Article  PubMed  Google Scholar 

  4. Schlosser S, Wagner S, Mühlisch J, Hasselblatt M, Gerss J, Wolff JE, Frühwald MC (2010) MGMT as a potential stratification marker in relapsed high-grade glioma of children: the HIT-GBM experience. Pediatr Blood Cancer 54:228–237

    PubMed  Google Scholar 

  5. Brandes AA, Tosoni A, Cavallo G, Reni M, Franceschi E, Bonaldi L, Bertorelle R, Gardiman M, Ghimenton C, Iuzzolino P, Pession A, Blatt V, Ermanni M (2006) Correlations between O6-methylguanine DNA methyltransferase promoter methylation status, 1p and 19q deletions, and response to temozolomide in anaplastic and recurrent oligodendroglioma: a prospective GICNO study. J Clin Oncol 24:4746–4753

    Article  CAS  PubMed  Google Scholar 

Download references

Potential competing interests

No conflict of interest to be declared.

Author information

Authors and Affiliations

  1. Department of Medical Diagnostic Sciences and Special Therapies, Surgical Pathology & Cytopathology Unit, University Hospital of Padova, Via Gabelli 61, 35121, Padova, Italy

    Matteo Fassan & Marina Paola Gardiman

  2. Department of Experimental Biomedical Sciences, University of Padova, Padova, Italy

    Evelyne Tassone & Maurizio Onisto

  3. Department of Pediatrics, Division of Pediatrics, University Hospital of Padova, Padova, Italy

    Giorgio Perilongo

  4. Department of Pediatrics, Pediatric Neurosurgery Unit, University Hospital of Padova, Padova, Italy

    Domenico D’Avella

Authors
  1. Matteo Fassan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Evelyne Tassone
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Maurizio Onisto
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Giorgio Perilongo
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Domenico D’Avella
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Marina Paola Gardiman
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Marina Paola Gardiman.

Additional information

Consent: written informed consent was obtained from the patients' parents for publication of this letter.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fassan, M., Tassone, E., Onisto, M. et al. MGMT promoter methylation in pediatric high-grade gliomas. Childs Nerv Syst 27, 7–8 (2011). https://doi.org/10.1007/s00381-010-1313-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00381-010-1313-9

Keywords

Search

Navigation