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Child's Nervous System

, 25:1547 | Cite as

Reproducible and persistent weakness in adult rats after surgical resection of motor cortex: evaluation with limb placement test

  • Do-Hun Lee
  • Seok Ho Hong
  • Seung-Ki Kim
  • Chang-Sub Lee
  • Ji Hoon Phi
  • Byung-Kyu Cho
  • Kyu-Chang WangEmail author
Original Paper

Abstract

Object

The purpose of this study was to develop a new rat model for surgical brain injury with motor weakness and to find an adequate behavior test for the application of the model.

Methods

Thirty rats were divided into three groups: craniectomy (n = 10), durotomy (n = 10), and corticectomy (n = 10) groups. The coordinates of the three points from the bregma (coordinate A = +4,+1, B = −2,+1, and C = +4,+6). We evaluated right limb motor performance by the modified limb placement test and the cylinder test.

Conclusion

Persistent motor weakness was observed for 2 months in the corticectomy group by the limb placement test, whereas the cylinder test could not detect the weakness. We established a reproducible and persistent rat brain injury model and found that the modified limb placement test is sensitive enough to evaluate residual subtle weakness in this model.

Keywords

Corticectomy Motor cortex Motor weakness Limb placement test Functional recovery Rat 

Notes

Acknowledgments

This study was supported in part by the Korea Health 21 R & D Project, Ministry of Health & Welfare, Republic of Korea (grant no. 01-PJ10-PG8-O1ECO01-0010) and a KT&G Grant-in-Aid for neonatal research (SNUCH20080201).

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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Do-Hun Lee
    • 1
  • Seok Ho Hong
    • 2
  • Seung-Ki Kim
    • 1
  • Chang-Sub Lee
    • 3
  • Ji Hoon Phi
    • 1
  • Byung-Kyu Cho
    • 1
  • Kyu-Chang Wang
    • 1
    Email author
  1. 1.Department of NeurosurgerySeoul National University College of MedicineSeoulKorea
  2. 2.Department of Neurosurgery, Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea
  3. 3.Department of Neurosurgery, College of MedicineCheju National UniversityJejuKorea

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