Ependymoma: lessons from the past, prospects for the future
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The invited review from Little et al. sheds a light on the potentially hazardous arbitrary decision-making process physicians may use in the management of intracranial ependymoma . Based on their review of the literature, Little et al. conclude that “deferring adjuvant radiotherapy for low-risk patients with childhood ependymomas who have undergone complete resection is a reasonable treatment option”. This statement is problematic since a significant number of readers may consider it as a take home message and apply this recommendation in their daily practice.
Unfortunately, the history of childhood ependymoma has already suffered the consequences of similar arbitrary statements in the early 1980 when Salazar et al., based on a review of autopsy material concluded that patients with high-grade ependymomas (regardless of location) or with low-grade infratentorial tumors with positive CSF or subarachnoid findings of spinal metastases should be treated with craniospinal...
KeywordsPostoperative Radiation Spinal Metastasis Craniospinal Radiation hTERT Expression Pediatric Patient Population
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