Child's Nervous System

, Volume 25, Issue 8, pp 925–931 | Cite as

Demonstration of fluid channels in human dura and their relationship to age and intradural bleeding

  • W. Squier
  • E. Lindberg
  • J. Mack
  • S. Darby
Original Paper



This paper aims to make a systematic study of human dura to establish the presence of fluid transport channels and their relationship to age.


Samples of parasagittal dura from autopsy cases from mid-gestation to the ninth decade were examined by light microscopy.


We have demonstrated the presence of unlined rounded spaces, uncommon in the fetus and neonate but increasingly evident after 30 weeks of postnatal life. We have shown that intradural bleeding is inversely correlated with the presence of these channels and with age.


We suggest that dural maturation, involving the development of arachnoid granulations, may be related to dilatation of intradural fluid channels, allowing them to be identified histologically. The risk of reflux of blood into the dura appears to reduce with age.


Dura CSF transport Infant Dural bleeding Arachnoid granulations 



We would like to thank the technical staff at the Department of Neuropathology, John Radcliffe Hospital, for careful preparation of these tissues for study. We are indebted to the families of the patients studied for their generosity in donating tissues for research.

Conflict of interest statement

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  1. 1.Department of NeuropathologyWest Wing, John Radcliffe HospitalOxfordUK
  2. 2.Department of PathologyLund University HospitalLundSweden
  3. 3.Department of RadiologyPenn State Hershey Medical CenterHersheyUSA
  4. 4.Clinical Trial Service Unit, Nuffield Department of Clinical MedicineUniversity of OxfordOxfordUK

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