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Child's Nervous System

, Volume 25, Issue 8, pp 925–931 | Cite as

Demonstration of fluid channels in human dura and their relationship to age and intradural bleeding

  • W. Squier
  • E. Lindberg
  • J. Mack
  • S. Darby
Original Paper

Abstract

Purpose

This paper aims to make a systematic study of human dura to establish the presence of fluid transport channels and their relationship to age.

Methods

Samples of parasagittal dura from autopsy cases from mid-gestation to the ninth decade were examined by light microscopy.

Results

We have demonstrated the presence of unlined rounded spaces, uncommon in the fetus and neonate but increasingly evident after 30 weeks of postnatal life. We have shown that intradural bleeding is inversely correlated with the presence of these channels and with age.

Conclusions

We suggest that dural maturation, involving the development of arachnoid granulations, may be related to dilatation of intradural fluid channels, allowing them to be identified histologically. The risk of reflux of blood into the dura appears to reduce with age.

Keywords

Dura CSF transport Infant Dural bleeding Arachnoid granulations 

Notes

Acknowledgements

We would like to thank the technical staff at the Department of Neuropathology, John Radcliffe Hospital, for careful preparation of these tissues for study. We are indebted to the families of the patients studied for their generosity in donating tissues for research.

Conflict of interest statement

The authors declare that they have no conflict of interest.

References

  1. 1.
    De La Motte DJ (1978) Removal of horseradish peroxidase and fluorescein-labelled dextran from CSF spaces of rabbit optic nerve. A light and electron microscope study. Exp Eye Res 27:585–594CrossRefGoogle Scholar
  2. 2.
    Johnston M, Armstrong D, Koh L (2007) Possible role of the cavernous sinus veins in cerebrospinal fluid absorption. Cerebrospinal Fluid Res 4:3PubMedCrossRefGoogle Scholar
  3. 3.
    Zenker W, Bankoul S, Braun JS (1994) Morphological indications for considerable diffuse reabsorption of cerebrospinal fluid in spinal meninges particularly in the areas of meningeal funnels. An electronmicroscopical study including tracing experiments in rats. Anat Embryol (Berl) 189:243–258Google Scholar
  4. 4.
    Christensen E (1944) Studies on chronic subdural haematoma. Acta Psychiatr Scand 19:69–148CrossRefGoogle Scholar
  5. 5.
    Balo J (1950) The dural venous sinuses. Anat Rec 106:319–324PubMedCrossRefGoogle Scholar
  6. 6.
    Fox RJ, Walji AH, Mielke B, Petruk KC, Aronyk KE (1996) Anatomic details of intradural channels in the parasagittal dura: a possible pathway for flow of cerebrospinal fluid. Neurosurg 39:84–90CrossRefGoogle Scholar
  7. 7.
    Han H, Tao W, Zhang M (2007) The dural entrance of cerebral bridging veins into the superior sagittal sinus: an anatomical comparison between cadavers and digital subtraction angiography. Neuroradiol 49:169–175CrossRefGoogle Scholar
  8. 8.
    Grzybowski DM, Herderick EE, Kapoor KG, Holman DW, Katz SE (2007) Human arachnoid granulations Part I: a technique for quantifying area and distribution on the superior surface of the cerebral cortex. Cerebrospinal Fluid Res 4:6PubMedCrossRefGoogle Scholar
  9. 9.
    O'Connell JEA (1934) Some observations on the cerebral veins. Brain 57:484–503CrossRefGoogle Scholar
  10. 10.
    Papaiconomou C, Zakharov A, Azizi N, Djenic J, Johnston M (2004) Reassessment of the pathways responsible for cerebrospinal fluid absorption in the neonate. Childs Nerv Syst 20:29–36PubMedCrossRefGoogle Scholar
  11. 11.
    Gros Clark WE (1920) On the Pacchionian bodies. J Anat 55:40–48PubMedGoogle Scholar
  12. 12.
    Oi S, Di Rocco C (2006) Proposal of "evolution theory in cerebrospinal fluid dynamics" and minor pathway hydrocephalus in developing immature brain. Childs Nerv Syst 22:662–669PubMedCrossRefGoogle Scholar
  13. 13.
    Dandy W (1929) Where is cerebrospinal fluid absorbed? J of the Am Med Assoc 92:2012–2014Google Scholar
  14. 14.
    Johanson CE, Duncan JA III, Klinge PM, Brinker T, Stopa EG, Silverberg GD (2008) Multiplicity of cerebrospinal fluid functions: new challenges in health and disease. Cerebrospinal Fluid Res 5:10PubMedCrossRefGoogle Scholar
  15. 15.
    Welch K, Friedman V (1960) The cerebrospinal fluid valves. Brain 83:454–469PubMedCrossRefGoogle Scholar
  16. 16.
    Friede RL FR (1989) Hemorrhages in Asphyxiated Premature Infants. Dev. Neuropathol. Gottingen: Springer, 44–58Google Scholar
  17. 17.
    Smith C, Bell JE, Keeling JW, Risden RA (2003) Dural haemorrhage in nontraumatic infant deaths: does it explain the bleeding in 'shaken baby syndrome'? Geddes JE et al. A response. Neuropathol Appl Neurobiol 29:411–412Google Scholar
  18. 18.
    Kibayashi K, Shojo H, Sumida T (2005) Dural hemorrhage of the tentorium on postmortem cranial computed tomographic scans in children. Forensic Sci Int 154:206–209PubMedCrossRefGoogle Scholar
  19. 19.
    Orlin JR, Osen KK, Hovig T (1991) Subdural compartment in pig: a morphologic study with blood and horseradish peroxidase infused subdurally. Anat Rec 230:22–37PubMedCrossRefGoogle Scholar
  20. 20.
    Haines DE, Harkey HL, al Mefty O (1993) The "subdural" space: a new look at an outdated concept. Neurosurgery 32:111–120PubMedCrossRefGoogle Scholar
  21. 21.
    Browder J, Kaplan HA, Krieger AJ (1975) Venous lakes in the suboccipital dura mater and falx cerebelli of infants: surgical significance. Surg Neurol 4:53–55PubMedGoogle Scholar
  22. 22.
    Turner L (1961) The structure of arachnoid granulations with observations on their physiological and pathological significance. Ann R Coll Surg Engl 29:237–264PubMedGoogle Scholar
  23. 23.
    Weller RO (2005) Microscopic morphology and histology of the human meninges. Morphologie 89:22–34PubMedCrossRefGoogle Scholar
  24. 24.
    von During M, Andres KH (1991) Sensory nerve fiber terminals in the arachnoid granulations of non-human primates. Neurosci Lett 127:121–124CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  1. 1.Department of NeuropathologyWest Wing, John Radcliffe HospitalOxfordUK
  2. 2.Department of PathologyLund University HospitalLundSweden
  3. 3.Department of RadiologyPenn State Hershey Medical CenterHersheyUSA
  4. 4.Clinical Trial Service Unit, Nuffield Department of Clinical MedicineUniversity of OxfordOxfordUK

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