Child's Nervous System

, 25:63 | Cite as

Paravertebral malignant tumors of childhood: analysis of 28 pediatric patients

  • Dilek Gunes
  • Kamer Mutafoglu Uysal
  • Hilal Cetinkaya
  • Hande Gazeteci Tekin
  • Nurullah Yuceer
  • Faik Sarialioglu
  • Nur Olgun
Original Paper



To evaluate the clinical features and treatment results of the primary paravertebral malignant tumors (PMTs) in our department.


Medical records of 28 children with primary PMTs treated between 1988–2007 were analyzed retrospectively.


Primary PMTs constituted 4.8% of the cancer cases in our department. Tumor diagnoses were mostly neuroblastoma (46.4%) and soft tissue sarcomas (35.7%). These cases presented with pain (64.3%), motor dysfunction (42.8%), sphincter dysfunction (35.7%), palpable mass (32.1%), and sensory deficits (7.1%). All tumors were extradural. Physical examination revealed motor deficits (53.6%), deep tendon reflex alterations (53.6%), sphincter dysfunction (35.7%), pathologic reflexes (25%), abnormal cutaneous reflexes (25%), and sensory deficits (17.8%). Sixteen had cord compression (CC; 13 clinical, three radiological CC). Eleven of them presented with advanced disease. Seven were managed by surgical departments by primary surgery (three unresponsive). Others were managed by pediatric oncology: five with corticosteroids ± chemotherapy (one unresponsive), one with radiotherapy (RT), and two with surgery for the clinical CC. Surgery was tumor excision in nine, laminectomy in nine, laminotomy in one, and delayed surgery after chemotherapy in two cases. In chemotherapy and surgery groups, there were neurologic sequela associated with the advanced disease at diagnosis in 38% and 37%, respectively. At 3-year median follow-up, nine patients died, 17 are alive (four with neurologic sequela), and two are lost of follow-up.


Majority of cases presented with advanced disease. Late referral is the major cause of morbidity and mortality. The CC caused by PMTs should be initially managed with corticosteroids ± chemotherapy to avoid the adverse late effects of RT and surgery.


Paravertebral malignant tumors Spinal cord compression Childhood 


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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Dilek Gunes
    • 1
  • Kamer Mutafoglu Uysal
    • 1
  • Hilal Cetinkaya
    • 2
  • Hande Gazeteci Tekin
    • 2
  • Nurullah Yuceer
    • 3
  • Faik Sarialioglu
    • 4
  • Nur Olgun
    • 1
  1. 1.Department of Pediatric OncologyDokuz Eylul University Institute of OncologyIzmirTurkey
  2. 2.Department of PediatricsDokuz Eylul University Medical SchoolIzmirTurkey
  3. 3.Department of NeurosurgeryDokuz Eylul University Medical SchoolIzmirTurkey
  4. 4.Department of Pediatric OncologyBaskent University Medical SchoolAnkaraTurkey

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