Child's Nervous System

, Volume 24, Issue 12, pp 1437–1445

Epilepsy surgery in tuberous sclerosis complex: early predictive elements and outcome

  • F. Teutonico
  • R. Mai
  • O. Devinsky
  • G. Lo Russo
  • H. L. Weiner
  • P. Borrelli
  • U. Balottin
  • P. Veggiotti
Original Paper

DOI: 10.1007/s00381-008-0679-4

Cite this article as:
Teutonico, F., Mai, R., Devinsky, O. et al. Childs Nerv Syst (2008) 24: 1437. doi:10.1007/s00381-008-0679-4

Abstract

Aim

The aim of the study was to evaluate the surgical treatment of epilepsy and detection of possible early surgery predictive elements in patients with tuberous sclerosis complex (TSC).

Materials and methods

Forty-two TSC patients with epilepsy were selected and divided into two main groups: definite and fruste forms. Definite forms were divided into different groups: patients with pharmacologically controlled epilepsy, patients with pharmacoresistant epilepsy excluded from surgery after an extensive presurgical assessment, and patients with a pharmacoresistant epilepsy who underwent surgery. We compared the definite TSC groups to identify elements that predict surgical candidacy. Second, we compared all operated patients to assess surgical outcome.

Conclusion

We found several factors that could predict a surgical intervention even if identification of patients with refractory epilepsy who can benefit from surgery is an evolving process. Also, several positive factors for good surgical outcome were identified. Patients with the fruste form had excellent surgical outcome.

Keywords

Tuberous sclerosis complex Epilepsy Surgery 

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • F. Teutonico
    • 1
  • R. Mai
    • 2
  • O. Devinsky
    • 3
    • 4
  • G. Lo Russo
    • 2
  • H. L. Weiner
    • 3
    • 5
  • P. Borrelli
    • 6
  • U. Balottin
    • 1
  • P. Veggiotti
    • 1
  1. 1.Child Neuropsychiatry Unit, Department of Child Neurology and Psychiatry, IRCCS “C. Mondino” FoundationUniversity of PaviaPaviaItaly
  2. 2.C. Munari Epilepsy Surgery CenterCà Granda Niguarda HospitalMilanItaly
  3. 3.Comprehensive Epilepsy CenterNew York University Medical CenterNew YorkUSA
  4. 4.Department of NeurologyNew York University Medical CenterNew YorkUSA
  5. 5.Division of Pediatric Neurosurgery, Department of NeurosurgeryNew York University Medical CenterNew YorkUSA
  6. 6.Department of Applied Health SciencesUniversity of PaviaPaviaItaly

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