Pituitary tumors in children: clinical analysis of 21 cases
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The aim of this study is to review the results of surgery for pituitary adenomas in children less than 18 years old.
Materials and methods
A retrospective review was done of pituitary adenoma patients with the age of less than 18 years who were treated in the period 1979–2003 at Dr. Shariati Hospital.
Twenty-one patients (12 girls and 9 boys) were identified. The age range (mean) in girls and boys was 9–18 (15.8) and 9–17 (14.8) years, respectively. The duration of follow-up was 1–23 (13.4) years. Eight patients (38.1%) had adrenocorticotropic hormone-secreting tumors, 33.3% had prolactin-secreting tumors, 19% had growth hormone-secreting tumors, and 9.53% had nonfunctioning adenomas. Multidisciplinary management included surgery and, if necessary, reoperation with/without radiotherapy and pharmacotherapy. Eleven patients, mostly with prolactinomas, acromegaly, and nonfunctioning adenomas, needed reoperation and radiotherapy. There were two deaths, one of which was because of apoplexy. The biological behavior of pediatric pituitary adenomas seems more aggressive than adults’ adenomas. The chance of pituitary apoplexy in pediatric invasive pituitary adenoma is high.
KeywordsChildren Pituitary adenomas Clinical analysis Pituitary apoplexy
I thank Dr. Babak Ghassemi for his comments and editing.
- 8.De Menis E, Visentin A, Billeci D, Tramontin P, Agostini S, Marton E, Conte N (2001) Pituitary adenomas in childhood and adolescence. Clinical analysis of 10 cases. J Endocrinol Investig 24:92–97Google Scholar
- 11.Farioli B, Ferrante L, Celli P (1983) Pituitary adenomas with onset during puberty, features and treatment. J Neurosurg 59:590–595Google Scholar
- 15.Hoffman HJ (1982) Pituitary adenomas. In: American Association of Neurological Surgeons (eds) Pediatric neurosurgery: surgery of developing nervous system. Grune & Stratton, NY, pp 493–499Google Scholar
- 21.Laws ER, Scheithauer BW, Groover RV (1987) Pituitary adenomas in childhood and adolescence. Rog Exp Tumor Res 30:359–361Google Scholar
- 22.Laws ER, Scheithauer BW, Groover RV (1994) Pituitary adenoma in adolescents: a biologically more aggressive disease. Radiology 92:869–872Google Scholar
- 25.Martins AN, Hales M, Wilson CB (1981) Cerebellar metastasis from prolactinoma during treatment with bromocriptine. J Neurosurg 55:615–619Google Scholar
- 31.Partigton MD, Davis DH, Laws ER, Scheithauer BW (1994) Pituitary adenomas in childhood and adolescence: results of transsphenoidal surgery. J Neurosurg 80:209–216Google Scholar