Child's Nervous System

, Volume 22, Issue 11, pp 1379–1394

Current concepts in the molecular genetics of pediatric brain tumors: implications for emerging therapies

  • Mandeep S. Tamber
  • Krishan Bansal
  • Muh-Lii Liang
  • Todd G. Mainprize
  • Bodour Salhia
  • Paul Northcott
  • Michael Taylor
  • James T. Rutka
Invited Paper

DOI: 10.1007/s00381-006-0187-3

Cite this article as:
Tamber, M.S., Bansal, K., Liang, ML. et al. Childs Nerv Syst (2006) 22: 1379. doi:10.1007/s00381-006-0187-3

Abstract

Background

The revolution in molecular biology that has taken place over the past 2 decades has provided researchers with new and powerful tools for detailed study of the molecular mechanisms giving rise to the spectrum of pediatric brain tumors. Application of these tools has greatly advanced our understanding of the molecular pathogenesis of these lesions.

Review

After familiarizing readers with some promising new techniques in the field of oncogenomics, this review will present the current state of knowledge as it pertains to the molecular biology of pediatric brain neoplasms. Along the way, we hope to highlight specific instances where the detailed mechanistic knowledge acquired thus far may be exploited for therapeutic advantage.

Keywords

Brain neoplasms Molecular biology Pediatrics Review Therapeutics 

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Mandeep S. Tamber
    • 1
    • 2
  • Krishan Bansal
    • 1
    • 2
  • Muh-Lii Liang
    • 1
    • 2
  • Todd G. Mainprize
    • 1
    • 2
  • Bodour Salhia
    • 1
    • 2
  • Paul Northcott
    • 1
    • 2
  • Michael Taylor
    • 1
    • 2
  • James T. Rutka
    • 1
    • 2
    • 3
  1. 1.Division of Neurosurgery, The Hospital for Sick ChildrenThe University of TorontoTorontoCanada
  2. 2.Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick ChildrenThe University of TorontoTorontoCanada
  3. 3.The Division of Neurosurgery, Suite 1504The Hospital for Sick ChildrenTorontoCanada

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