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Child's Nervous System

, Volume 22, Issue 8, pp 1012–1017 | Cite as

Gamma knife radiosurgery for callosotomy in children with drug-resistant epilepsy

  • Hans Georg EderEmail author
  • Michael Feichtinger
  • Tom Pieper
  • Senta Kurschel
  • Oskar Schroettner
Special Annual Issue

Abstract

Objectives

Gamma knife radiosurgery as a noninvasive procedure is increasingly used as a treatment option in patients with intractable seizures. We investigated efficacy and safety of gamma knife radiosurgery (GKRS) for callosotomy in children.

Materials and methods

Between 2000 and 2004 three children between 4 and 14 years (mean 8 years) underwent radiosurgical callosotomy. One child presented with Lennox–Gastaut syndrome, two with hemispheric cortical dysplasia. These two children underwent functional hemispherotomy before GKRS. GKRS was performed with a marginal dose of 55–60 Gy on the 50% isodose.

Results

Mean follow-up was 35 months. Radiosurgical callosotomy was ineffective in one child with the Lennox–Gastaut syndrome, whereas in the remaining two children, a 100% seizure reduction of generalized tonic-clonic seizures, 20–70% reduction of partial seizures, and a progress in mental and physical development was achieved. No postradiosurgical side effects were observed in all children.

Conclusion

Radiosurgical callosotomy might be offered after hemispherotomy to complete callosal resection. However, larger number of patients and longer follow-ups are needed to draw final conclusions.

Keywords

Gamma knife Radiosurgery Epilepsy Callosotomy Children Hemispherotomy 

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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Hans Georg Eder
    • 1
    Email author
  • Michael Feichtinger
    • 2
  • Tom Pieper
    • 3
  • Senta Kurschel
    • 1
  • Oskar Schroettner
    • 1
  1. 1.Department of NeurosurgeryMedical UniversityGrazAustria
  2. 2.Department of NeurologyMedical University of GrazGrazAustria
  3. 3.Neuropediatric Clinic and Clinic for Neurorehabilitation—Epilepsy Center for Children and AdolescentsVogtareuthGermany

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