Child's Nervous System

, Volume 22, Issue 10, pp 1332–1337

Spontaneous regression of optic pathways gliomas in three patients with neurofibromatosis type I and critical review of the literature

  • Manolo Piccirilli
  • Jacopo Lenzi
  • Catia Delfinis
  • Guido Trasimeni
  • Maurizio Salvati
  • Antonino Raco
Original Paper

DOI: 10.1007/s00381-006-0061-3

Cite this article as:
Piccirilli, M., Lenzi, J., Delfinis, C. et al. Childs Nerv Syst (2006) 22: 1332. doi:10.1007/s00381-006-0061-3

Abstract

Case reports

The authors report their experience about three children (two girls, one boy; average age 1.6 years) with a spontaneous regression of optic gliomas. All of them had a previous diagnosis of neurofibromatosis type 1 (NF 1). None of them underwent surgery or biopsy nor received chemotherapy or radiotherapy. The complete regression was documented by MRI scans performed during a mean follow-up of 6.3 years.

Literature review

Moreover, the authors analyze the features of the 16 cases previously reported in English literature of spontaneously regressed optic gliomas with an overview of the different therapeutic strategies. The knowledge that this kind of tumor, particularly in young patients, may regress is important in the decision of the best therapeutic approach.

Keywords

Optic gliomas Magnetic resonance imaging Neurofibromatosis type I 

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Manolo Piccirilli
    • 1
  • Jacopo Lenzi
    • 1
  • Catia Delfinis
    • 1
  • Guido Trasimeni
    • 1
    • 2
  • Maurizio Salvati
    • 1
    • 3
  • Antonino Raco
    • 1
    • 3
  1. 1.Department of Neurosurgical Sciences, NeurosurgeryUniversity of RomeRomeItaly
  2. 2.Department of NeuroradiologySant’Andrea HospitalRomeItaly
  3. 3.NeurosurgeryINM NeuromedPozzilli (IS)Italy
  4. 4.RomeItaly

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