Child's Nervous System

, Volume 21, Issue 3, pp 211–220 | Cite as

Astroblastoma in childhood: pathological and clinical analysis

  • Ramon Navarro
  • Aaron J. Reitman
  • Guillermo A. de León
  • Stewart Goldman
  • Maryanne Marymont
  • Tadanori Tomita
Original Paper

Abstract

Object

The object was to describe the clinical, radiologic, and pathologic features of astroblastomas in an unselected group of children who were treated in a single institution during an 11-year period.

Methods

Eight children with astroblastomas of the brain were examined. Diagnosis was based on cell morphology, vascular attachment of the cell main process, lack of an epithelial-free surface differentiation, and poor intercellular cohesiveness. In addition to sections, tumor smears and electron microscopy were required for demonstrating or confirming such features.

Conclusions

Clinical findings seem to confirm an apparent predilection of astroblastomas for younger children (median age of onset, 5 years) and the existence of two prognostically different types of tumor—well differentiated (low grade) and anaplastic (high grade). Microscopic findings suggest a closer resemblance of tumor cells to astroblasts rather than to “tanycytes” or ependymal cells. It seems, however, that anaplastic astroblasts have a tendency to evolve toward, or be associated with, less differentiated cells, either neuroepithelial or sarcomatous.

Keywords

Astroblast Astroblastoma Ependymoma Gliomyosarcoma Medullo-epithelioma Tanycyte 

Notes

Acknowledgements

We are grateful to Ms. D. Sciortino for printing the photomicrographs.

References

  1. 1.
    Auer RN, Becker LE (1983) Cerebral medulloepithelioma with bone, cartilage, and striated muscle. Light microscopic and immunohistochemical study. J Neuropathol Exp Neurol 42:256–267PubMedGoogle Scholar
  2. 2.
    Bailey P (1965) Cellular types in primary tumors of the brain. In: Penfiled W (ed) Cytology and cellular pathology of the nervous system. Hoeber, New York, p 1932. Reprinted by Hafner, New YorkGoogle Scholar
  3. 3.
    Bailey P, Bucy PC (1930) Astroblastomas of the brain. Acta Psychiatr Neurol 5:439–461Google Scholar
  4. 4.
    Bailey P, Cushing H (1926) A classification of the tumors of the glioma group on a histogenic basis with a correlation study of prognosis. Lippincott, PhiladelphiaGoogle Scholar
  5. 5.
    Baka JJ, Patel SC, Roebuck JR, Hearshen DO (1993) Predominantly extraaxial astroblastoma: imaging and proton MR spectroscopy features. Am J Neuroradiol 14:946–950PubMedGoogle Scholar
  6. 6.
    Barnard RO, Bradford R, Scott T, Thomas DGT (1986) Gliomyosarcoma. Report of a case of rhabdomyosarcoma arising in a malignant glioma. Acta Neuropathol (Berl) 69:23–27Google Scholar
  7. 7.
    Bergstrand H (1935) Über das sog. Astrocytom in Kleinhirn. Virchows Arch A Pathol Anat Histopathol 287:538–548Google Scholar
  8. 8.
    Bonnin JM, Rubinstein LJ (1989) Astroblastomas a pathological study of 23 tumors, with a postoperative follow-up in 13 patients. Neurosurgery 25:6–13Google Scholar
  9. 9.
    Brat DJ, Hirose Y, Cohen KJ, Feuerstein BG, Burger PC (2000) Astroblastoma: clinicopathologic features and chromosomal abnormalities defined by comparative genomic hybridization. Brain Pathol 10:342–352PubMedGoogle Scholar
  10. 10.
    Burger PC, Scheithauer BW (1994) Tumors of the central nervous system. In: Atlas of tumor pathology, third series, fascicle 10. Armed Forces Institute of Pathology, Washington, DCGoogle Scholar
  11. 11.
    Cabello A, Madero S, Castresana A, Diaz-Lobato R (1991) Astroblastoma: electron microscopy and immunohistochemical findings: case report. Surg Neurol 35:116–121PubMedGoogle Scholar
  12. 12.
    Catalan-Uribarrena G, De Las Heras-Echeverria P, Caton-Santaren B, Martinez-Soto LJ, Torrecilla-Sardony MV, Ramos-Gonzalez A (2002) Cerebral astroblastoma: report of a case and literature review. Neurocirugia 13:378–384PubMedGoogle Scholar
  13. 13.
    Childhood Brain Tumor Consortium (1998) A study of childhood brain tumors based on surgical biopsies from ten North American institutions: sample description. J Neurooncol 6:9–23Google Scholar
  14. 14.
    Del Río-Hortega P (1962) Anatomía microscópica de los tumores del sistema nervioso central y periférico. In: Proceedings of the Congreso Internacional de Lucha Científica y Social Contra el Cáncer. Madrid, 1933. English translation by A Pineda, GV Russell, KM Earle. Thomas, SpringfieldGoogle Scholar
  15. 15.
    De Reuck J, Van de Velde E, Vander Eecken H (1975) The angioarchitecture of the astroblastoma. Clin Neurol Neurosurg 78:89–98PubMedGoogle Scholar
  16. 16.
    Goldman RL (1969) Gliomyosarcoma of the cerebrum. Report of a unique case. Am J Clin Pathol 52:741–744PubMedGoogle Scholar
  17. 17.
    Hoag G, Sima AA, Rozdilsky B (1986) Astroblastoma revisited: a report of three. Acta Neuropathol 70:10–16PubMedGoogle Scholar
  18. 18.
    Horstmann E (1954) Die Faserglia des Selachiergehirns. Z Zellforsch Mikrosk Anat 39:588–617PubMedGoogle Scholar
  19. 19.
    Husain AN, Leestma JE (1986) Cerebral astroblastoma: immunohistochemical and ultrastructural features. Case report. J Neurosurg 64:657–661Google Scholar
  20. 20.
    Jay V, Edwards V, Squire J, Rutka J (1993) Astroblastoma: report of a case with ultrastructural, cell kinetic, and cytogenetic analysis. Pediatr Pathol 13:323–332Google Scholar
  21. 21.
    Kleinhius P, Burger PC, Scheithauer BW (1993) Histologic typing of tumors of the central nervous system. In: World Health Organization, international histological classification of tumors. Springer, Berlin Heidelberg New YorkGoogle Scholar
  22. 22.
    Kubota T, Hirano A, Sato K, Yamamoto S (1985) The fine structure of astroblastoma. Cancer 55:745–750Google Scholar
  23. 23.
    Kujas M, Faillot T, Roncier B, Catala M, Poirier J (2000) Astroblastoma revisited. Report of two cases with immunohistochemical and electron microscopic study. Histogenic considerations. Neuropathol Appl Neurobiol 26:295–298PubMedGoogle Scholar
  24. 24.
    Kuroiwa T, Ito U, Yamaguchi T, Okada K, Inaba Y (1980) [A case of astroblastoma of cerebral hemisphere in infant (Kobe)] (in Japanese). Shoni No Noshinkei 5:107–112Google Scholar
  25. 25.
    Mierau GW, Tyson RW, McGavran L, Parker NB, Partington MD (1999) Astroblastoma: ultrastructural observations on a case of high-grade type. Ultrastruct Pathol 23:325–332PubMedGoogle Scholar
  26. 26.
    Nakajima F, Yuda K, Kuwabara T, Yagishita S (1982) [Astroblastoma in newborn baby] (in Japanese). Neurol Surg 10:291–293Google Scholar
  27. 27.
    Nicholson DH, Green WR (1981) Pediatric ocular tumors. Masson, New YorkGoogle Scholar
  28. 28.
    Pizer B, Moss T, Oakhill A, Webb D, Coakham H (1985) Congenital astroblastoma: an immunohistochemical study. Case report. J Neurosurg 83:550–555Google Scholar
  29. 29.
    Port J, Brat D, Burger P, Pomper M (2002) Astroblastoma: radiologic–pathologic correlation and distinction from ependymoma. Am J Neuroradiol 23:243–247PubMedGoogle Scholar
  30. 30.
    Ramón y Cajal S (1952) Histologie du système nerveux de l’homme et des vertébrés. Translated by L. Azoulay. Maloine, Paris, 1909. Reprinted by Consejo Superior de Investigaciones Científicas, MadridGoogle Scholar
  31. 31.
    Rubinstein LJ, Herman MM (1989) The astroblastoma and its possible cytogenetic relationship to the tanycyte. An electron microscopic, immunohistochemical, tissue- and organ-culture study. Acta Neuropathol 78:479–483CrossRefGoogle Scholar
  32. 32.
    Sano K (1969) [Astrocytoma and astroblastoma] (in Japanese). No To Shinkei 21:610–613PubMedGoogle Scholar
  33. 33.
    Scharenberg K, Liss L (1969) Neuro-ectodermal tumors of the central and peripheral nervous system. Williams and Wilkins, Baltimore, pp 17–29Google Scholar
  34. 34.
    Shuangshoti S, Mitphraphan W, Kanvisetsri S, Griffiths L, Navalitloha Y, Pornthanakasem W, Mutirangura A (2000) Astroblastoma: report of a case with microsatellite analysis. Neuropathology 20:228–232PubMedGoogle Scholar
  35. 35.
    Thiessen B, Finlay J, Kulkarni R, Rosenblum MK (1998) Astroblastoma: does histology predict biologic behavior? J Neurooncol 40:59–65CrossRefPubMedGoogle Scholar
  36. 36.
    Yamashita J, Handa H, Yamagami T, Haebara H (1985) Astroblastoma of pure type. Surg Neurol 24:218–222Google Scholar
  37. 37.
    Yunten N, Ersahin Y, Demirtas E, Yalman O, Sener RN (1996) Cerebral astroblastoma resembling an extra-axial neoplasm. J Neuroradiol 23:38–40PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Ramon Navarro
    • 1
  • Aaron J. Reitman
    • 1
  • Guillermo A. de León
    • 2
  • Stewart Goldman
    • 3
  • Maryanne Marymont
    • 4
  • Tadanori Tomita
    • 1
  1. 1.Division of Pediatric Neurosurgery, Falk Brain Tumor Center, Children’s Memorial HospitalNorthwestern University Feinberg School of MedicineChicagoUSA
  2. 2.Division of Anatomic Pathology, Falk Brain Tumor Center, Children’s Memorial HospitalNorthwestern University Feinberg School of MedicineChicagoUSA
  3. 3.Division of Pediatric Hematology/Oncology, Falk Brain Tumor Center, Children’s Memorial HospitalNorthwestern University Feinberg School of MedicineChicagoUSA
  4. 4.Department of Radiation Oncology, Falk Brain Tumor Center, Children’s Memorial HospitalNorthwestern University Feinberg School of MedicineChicagoUSA

Personalised recommendations