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Child's Nervous System

, Volume 19, Issue 7–8, pp 471–476 | Cite as

Agenesis of corpus callosum: prenatal diagnosis and prognosis

  • Marie-Laure Moutard
  • Virginie Kieffer
  • Josué Feingold
  • François Kieffer
  • Fanny Lewin
  • Catherine Adamsbaum
  • Antoinette Gélot
  • Jaume Campistol i Plana
  • Patrick van Bogaert
  • Monique André
  • Gérard Ponsot
Original Paper

Abstract

Introduction

Agenesis of corpus callosum (ACC) is commonly diagnosed prenatally. When isolated, it appears to carry a good prognosis but studies are often retrospective and follow-up short. We report a prospective study of 17 children (11 boys, 6 girls) with prenatally diagnosed isolated ACC.

Methods

Neuropsychological evaluation was performed each year and results at the ages of 2, 4, and 6 years were compared.

Results

Febrile seizures occurred in 3 patients. Median intellectual quotient (IQ) was within the normal range (80–109) and nonrelated to partial or complete ACC, sex, or febrile seizures. Lower median IQ was significantly related to low cultural status. With age, the number of children with IQ in the lower range (80–89) increased and slowness, attentional troubles, and instability appeared.

Conclusion

This study demonstrates that if outcome of isolated ACC is favorable, a long follow-up is necessary: with age, IQ in the lower range and behavioral troubles are linked to difficulties in school.

Keywords

Corpus callosum Agenesis Antenatal Outcome 

Notes

Acknowledgements

Thanks are due to Drs. R. Arkwright, M.C. Aubry, F. Audibert, R. Bessis, J. De Laveaucoupet, M. Daumail, G. Hatem, F. Jacquemard, P. Plouin, D. Rodriguez, P. Sonigo, L. Vallée, Y. Ville, F. Wallois, and the "Groupe de Neurologie Foetale" for their contribution to and their help with this study.

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Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • Marie-Laure Moutard
    • 1
  • Virginie Kieffer
    • 1
  • Josué Feingold
    • 1
  • François Kieffer
    • 2
  • Fanny Lewin
    • 1
  • Catherine Adamsbaum
    • 1
  • Antoinette Gélot
    • 3
  • Jaume Campistol i Plana
    • 4
  • Patrick van Bogaert
    • 5
  • Monique André
    • 6
  • Gérard Ponsot
    • 1
  1. 1.Services de Neuropédiatrie, Obstétrique, RadiologieHôpital Saint Vincent de PaulParis Cedex 14France
  2. 2.Réanimation NéonataleInstitut de PuéricultureParisFrance
  3. 3.Laboratoire de NeuropathologieHôpital TrousseauParisFrance
  4. 4.NeuropediatriaHospital Sant Joan de DéuBarcelonaSpain
  5. 5.Departement de NeuropédiatrieULB, Hôpital ErasmeBrusselsBelgium
  6. 6.Service de NéonatologieMaternité RégionaleNancyFrance

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