Heart and Vessels

, Volume 18, Issue 1, pp 32–39

Histological study on the distribution of autonomic nerves in the human heart

  • H. Kawano
  • Ryozo Okada
  • Katsusuke Yano
ORIGINAL ARTICLE

Abstract.

 To investigate the distribution of autonomic nerves in the human heart, six autopsied hearts without cardiovascular disease were studied by a histochemical method for acetylcholinesterase (AChE) and by an immunohistochemical method for tyrosine hydroxylase (TH). The density of nerve distribution was microscopically calculated by the point-counting method to evaluate regional distribution of the autonomic nerves. There were more AChE-positive nerves and TH-positive nerves in the atrium than in the ventricle, and more at the base than at the apex in the ventricle. There were more AChE-positive nerves in the subendocardial area than in the subepicardial area of the myocardium. In the atrium, AChE-positive nerves were more numerous than TH-positive nerves. On the other hand, there were more TH-positive nerves than AChE-positive nerves in the ventricle. Predominancy of the distribution density at the anterior to the posterior wall of the ventricle was observed for TH-positive nerves. The different distribution patterns of sympathetic and parasympathetic nerves could modify cardiac performance under both physiologic and pathologic conditions.

Key words Acetylcholinesterase Tyrosine hydroxylase Nerves Human Histologic study 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag Tokyo 2003

Authors and Affiliations

  • H. Kawano
    • 1
  • Ryozo Okada
    • 2
  • Katsusuke Yano
    • 1
  1. 1.Department of Cardiovascular Medicine, Department of Medical and Dental Sciences, Graduate School of Biomedical Sciences, Nagasaki Univesity, Nagasaki, JapanJP
  2. 2.Research Gunma PAZ College School of Nursing, Gunma, JapanJP

Personalised recommendations