Heart and Vessels

, Volume 16, Issue 3, pp 99–104 | Cite as

Assessment of left ventricular end-systolic elastance from aortic pressure-left ventricular volume relations

  • Wen-Shin Lee
  • Masaru Nakayama
  • Wen-Pin Huang
  • Kuan-Rau Chiou
  • Chih-Cheng Wu
  • Erez Nevo
  • Barry Fetics
  • David A. Kass
  • Philip Yu-An Ding
  • C.-H. Chen
ORIGINAL ARTICLE

Abstract

The left ventricular (LV) end-systolic pressure–volume relation (ESPVR) is a load-insensitive method for evaluating LV contractility, which needs invasive measurement. Some noninvasive methods substitute peak aortic pressure (PS) for end-systolic LV pressure by assuming there is no difference between these pressures. However, this assumption has not been directly validated. With conductance catheter and dual micromanometers, ESPVRs and the slope (EesLV) were constructed from simultaneous LV pressures (LVP) and volumes, aortic pressures (AOP) and LV volumes (EesAO), and PS and LV end-ejection volumes (VEE) (EesPP-EEV) during preload reduction in 50 subjects. The ratio of steady-state PS over VEE (PS/VEE) was also checked. AOP and LVP displayed differences of 11 ± 6 and −30 ± 12 mmHg at the onset and end-ejection, respectively, and −2 ± 4 mmHg at end-systole. EesAO and EesLV were nearly identical: EesAO = 0.97 ×EesLV + 0.05, r2 = 0.99. EesPP-EEV correlated with EesLV (EesPP-EEV = 0.57 ×EesLV + 0.61, r2 = 0.46) but with much more scatter. PS/VEE correlated worst with EesLV. Central AOP can be substituted for LVP to derive EesLV. Other estimation methods yield weaker and poor correlations to directly measured Ees.

Key words Hemodynamics End-systolic pressure volume relationship Left ventricular function Central aortic pressure 

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Copyright information

© Springer-Verlag Tokyo 2002

Authors and Affiliations

  • Wen-Shin Lee
    • 1
  • Masaru Nakayama
    • 2
  • Wen-Pin Huang
    • 3
  • Kuan-Rau Chiou
    • 4
  • Chih-Cheng Wu
    • 1
  • Erez Nevo
    • 5
  • Barry Fetics
    • 5
  • David A. Kass
    • 5
  • Philip Yu-An Ding
    • 1
  • C.-H. Chen
    • 1
  1. 1.Division of Cardiology, Taipei Veterans General Hospital and the Cardiovascular Research Center, National Yang-Ming University, 201 Shih-Pai Road, Sec. 2, Taipei 11252, Taiwan Tel. +886-2-2871-2121 ext. 2073; Fax +886-2-2875-3580 e-mail: chench@vghtpe.gov.twTW
  2. 2.Division of Cardiology, St. Marianna University Hospital, Kawasaki, JapanJP
  3. 3.Division of Cardiology, Cheng Hsin Rehabilitation Medical Center, Taipei, TaiwanTW
  4. 4.Division of Cardiology, Kaohsiung Veterans General Hospital, Kaohsiung, TaiwanTW
  5. 5.Division of Cardiology, Department of Internal Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD, USAUS

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