Clinical impacts of changes of renal function during hospitalization depend on grades of renal dysfunction in acute decompensated heart failure

Heart and Vessels volume 35, pages509–520(2020)Cite this article

Abstract

Clinical impact of changes of renal function (RF) in heart failure (HF) hospitalization is controversial. This study aimed to clarify whether clinical impact of changes of RF during HF hospitalization depends on the intrinsic RF. In 786 hospitalized HF patients, RF were classified into 3 grades based on estimated glomerular filtration rate (eGFR, mL/min/1.73 m2) at discharge; ≥ 60 (n = 243), < 60 and ≥ 30 (n = 400), and < 30 (n = 143). Increase and decrease of serum creatinine over 0.3 mg/dL during HF hospitalization were defined as worsening renal function (WRF) and improved renal function (IRF), respectively, and remaining subjects were defined as stable RF. The primary endpoint was a composite of cardiovascular death and rehospitalization for HF. In all patients, WRF was not associated with clinical outcomes, although eGFR has a significant association with prognosis. Clinical outcomes did not differ between changes of RF patterns in both preserved and severely impaired RF groups. In contrast, IRF, not WRF, was an independent predictor of clinical outcomes in the moderately impaired RF group (HR 1.965, 95% CI 1.09–3.18, p = 0.01). Only in patients with moderately impaired RF, changes of RF were associated with clinical outcome, and IRF was an independent predictor of clinical outcomes.

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Funding

This study was supported by the Japan Heart Foundation Research Grant and JSPS KAKENHI (Grant number: 16K09416).

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Affiliations

  1. Department of Cardiology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan

    Seika Sai, Daishi Nakagawa, Tomofumi Nakatsukasa, Naoto Kawamatsu, Akinori Sugano & Yoshie Hamada-Harimura

  2. Department of Cardiology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan

    Yoshihiro Seo & Nobuyuki Ohte

  3. Department of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan

    Masayoshi Yamamoto, Tomoko Machino-Ohtsuka, Tomoko Ishizu & Masaki Ieda

  4. Department of Cardiology, Tsuchiura Clinical Education and Training Center, University of Tsukuba Hospital, Ibaraki, Japan

    Isao Nishi

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  1. Seika Sai
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  2. Yoshihiro Seo
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  3. Daishi Nakagawa
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Correspondence to Yoshihiro Seo.

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Sai, S., Seo, Y., Nakagawa, D. et al. Clinical impacts of changes of renal function during hospitalization depend on grades of renal dysfunction in acute decompensated heart failure. Heart Vessels 35, 509–520 (2020). https://doi.org/10.1007/s00380-019-01511-0

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Keywords

  • Improved renal function
  • Worsening renal function
  • Cardiorenal syndrome
  • Grade of renal dysfunction