Differences in prothrombotic response between the uninterrupted and interrupted apixaban therapies in patients undergoing cryoballoon ablation for paroxysmal atrial fibrillation: a randomized controlled study

  • Monami Ando
  • Yasuya IndenEmail author
  • Yukihiko Yoshida
  • Akinori Sairaku
  • Satoshi Yanagisawa
  • Hirohiko Suzuki
  • Ryo Watanabe
  • Masaki Takenaka
  • Mayuho Maeda
  • Toyoaki Murohara
Original Article


Periprocedural bleeding and thromboembolic events are worrisome complications of catheter ablation for atrial fibrillation (AF). Periprocedural anticoagulation management could decrease the risk of these complications. However, evaluation of the complications from pulmonary vein isolation using cryoballoon related to different anticoagulation strategies is limited. Therefore, we aimed to compare prothrombotic responses as assessed on the basis of d-dimer levels between the uninterrupted and interrupted apixaban therapies during cryoballoon ablation. Ninety-seven consecutive patients with paroxysmal AF scheduled to undergo cryoballoon ablation were randomly assigned in a 1:2 ratio to uninterrupted apixaban therapy (Group 1, n = 32) or interrupted apixaban therapy (Group 2, n = 65). d-Dimer levels were measured immediately before the ablation, at the end of the ablation, and 24 and 48 h after the procedure. No statistical difference was observed in the baseline characteristics between the two groups. The rates of hemorrhagic complications were similar in both groups (major bleeding: 3.1 vs. 1.5%; p = 0.61, and minor bleeding: 3.1 vs. 4.6%; p = 0.73, respectively). No thromboembolic events occurred in either group. However, d-dimer levels 48 h after the ablation increased more markedly following the procedure in Group 2 than in Group 1 (from 0.58 ± 0.16 to 1.01 ± 0.42 μg/mL vs. 0.58 ± 0.20 to 0.82 ± 0.25 μg/mL; p = 0.01). In conclusion, uninterrupted apixaban therapy during the periprocedural period of cryoballoon ablation for AF did not increase the risk of bleeding in this study and might reduce the periprocedural risk of subclinical hypercoagulable state.


Cryoballoon ablation Atrial fibrillation Apixaban Uninterrupted d-Dimer 


Compliance with ethical standards

Conflict of interest

None declared.


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Copyright information

© Springer Japan KK, part of Springer Nature 2019

Authors and Affiliations

  • Monami Ando
    • 1
    • 2
  • Yasuya Inden
    • 2
    Email author
  • Yukihiko Yoshida
    • 1
  • Akinori Sairaku
    • 3
  • Satoshi Yanagisawa
    • 2
  • Hirohiko Suzuki
    • 1
  • Ryo Watanabe
    • 1
  • Masaki Takenaka
    • 1
  • Mayuho Maeda
    • 1
  • Toyoaki Murohara
    • 2
  1. 1.Department of Cardiology, Cardiovascular CenterNagoya Daini Red Cross HospitalNagoyaJapan
  2. 2.Department of CardiologyNagoya University Graduate School of MedicineNagoyaJapan
  3. 3.Department of CardiologyOnomichi General HospitalHiroshimaJapan

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