Diastolic wall strain as a predictor of age-related cardiovascular events in patients with preserved left ventricular ejection fraction

  • Satoshi Tsujimoto
  • Yoko MiyasakaEmail author
  • Yoshinobu Suwa
  • Naoki Taniguchi
  • Shoko Kittaka
  • Kazuhiro Yamamoto
  • Ichiro Shiojima
Original Article


Diastolic wall strain (DWS) was reported as a simple and feasible echocardiographic index in assessing left ventricular (LV) diastolic stiffness. We sought to evaluate whether DWS predicts age-related cardiovascular events. Patients referred for transthoracic echocardiogram, those with preserved LV ejection fraction and no clinical heart failure were studied. Cardiovascular events were ascertained using Framingham criteria (myocardial infarction, coronary insufficiency, stroke, transient ischemic attack, congestive heart failure, or cardiovascular death). DWS was calculated with a validated formula. Cox proportional hazards modeling was used to assess the risk of cardiovascular events. Of a total number of 962 patients (mean age 60.9 ± 14.9 years, 48.0% men), 69 (7.2%) developed at least 1 cardiovascular event during a mean follow-up of 43 ± 32 months. After adjusting for cardiovascular comorbidities in a multivariable model, low DWS (≦ 0.33) was a significant independent predictor of cardiovascular events [hazard ratio (HR): 1.87, 95% confidential interval (CI) 1.04–3.36, P = 0.04]. Echocardiographic assessment of DWS may help in identifying the patients at increased risk for future age-related cardiovascular events.


Cardiovascular events Echocardiography Risk factors 



This study was supported in part by Grant-in-Aid for Scientific Research (C), 26461096, from the Ministry of Education, Culture, Sports, Science and Technology of Japan (Tokyo, Japan).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Japan KK, part of Springer Nature 2018

Authors and Affiliations

  • Satoshi Tsujimoto
    • 1
  • Yoko Miyasaka
    • 1
    Email author
  • Yoshinobu Suwa
    • 1
  • Naoki Taniguchi
    • 1
  • Shoko Kittaka
    • 1
  • Kazuhiro Yamamoto
    • 2
  • Ichiro Shiojima
    • 1
  1. 1.Division of Cardiology, Department of Medicine IIKansai Medical UniversityHirakataJapan
  2. 2.Department of Molecular Medicine and Therapeutics, Faculty of MedicineTottori UniversityTottoriJapan

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