Heart and Vessels

, Volume 34, Issue 3, pp 435–441 | Cite as

Far-infrared therapy improves ankle brachial index in hemodialysis patients with peripheral artery disease

  • Chun-Fan Chen
  • Fu-An Chen
  • Ann Charis Tan
  • Tsung-Lun Lee
  • Chia-Hao Chan
  • Chih-Ching LinEmail author
Original Article


Ankle brachial index (ABI) is a diagnostic tool for peripheral artery disease (PAD), which is an important issue in hemodialysis (HD) patients. We enrolled 198 maintenance HD patients in this study. PAD is defined as ABI ≤ 0.90. Only PAD patients received far-infrared (FIR) therapy using the WS TY101 FIR emitter for 40 min during each HD session, three times weekly for 6 months. The ABI was measured at the bilateral lower extremities for 4 times [pre-dialytic timing (0 min) and 40 min after the initiation of HD session at both day 0 and 6 months after the FIR therapy]. The primary outcome is the change in ABI. There were 51 out of 198 patients with PAD. In comparison with the period without FIR therapy in the 51 PAD patients, 6 months of FIR therapy significantly improved the ABI of the right/left side for 0 min (from 0.77 ± 0.19 to 0.81 ± 0.20, p = 0.027/0.79 ± 0.20 to 0.81 ± 0.17, p = 0.049), 40 min during HD (from 0.73 ± 0.23 to 0.83 ± 0.19, p < 0.001/from 0.77 ± 0.21 to 0.83 ± 0.18, p < 0.001), and the incremental change between 0 and 40 min (from − 0.04 ± 0.14 to 0.05 ± 0.13, p = 0.007/from − 0.05 ± 0.13 to 0.03 ± 0.11, p = 0.012), respectively. In conclusion, the application of FIR therapy for 40 min, three times weekly for 6 months, has improved the ABI of both lower extremities, thus providing a new strategy of PAD treatment in HD patients.


Ankle brachial index (ABI) Far-infrared (FIR) therapy (FIRAPY) Hemodialysis (HD) Peripheral artery disease (PAD) End-stage renal disease (ESRD) 



This work was supported by intramural grants (V103C-043, V104C-026, V105C-075, V106C-036, and V107C-034) from Taipei Veterans General Hospital, and grants from the National Science Council (NSC101-2314-B-010-024-MY3) and the Ministry of Science and Technology (MOST 104-2314-B-010-032 -MY3) in Taiwan

Conflict of interest



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Copyright information

© Springer Japan KK, part of Springer Nature 2018

Authors and Affiliations

  • Chun-Fan Chen
    • 1
    • 2
  • Fu-An Chen
    • 1
    • 2
  • Ann Charis Tan
    • 3
  • Tsung-Lun Lee
    • 1
    • 3
  • Chia-Hao Chan
    • 1
    • 3
  • Chih-Ching Lin
    • 1
    • 3
    Email author
  1. 1.School of MedicineNational Yang-Ming UniversityTaipeiTaiwan
  2. 2.Division of Nephrology, Department of Internal MedicineNational Yang-Ming University HospitalYilanTaiwan
  3. 3.Division of Nephrology, Department of MedicineTaipei Veterans General HospitalTaipeiTaiwan

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