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Associations between plasma nesfatin-1 levels and the presence and severity of coronary artery disease

  • Susumu Ibe
  • Yoshimi Kishimoto
  • Hanako Niki
  • Emi Saita
  • Tomohiko Umei
  • Kotaro Miura
  • Yukinori Ikegami
  • Reiko Ohmori
  • Kazuo Kondo
  • Yukihiko MomiyamaEmail author
Original Article
  • 44 Downloads

Abstract

Nesfatin-1 is a recently identified anorexigenic peptide mainly secreted from the brain and adipose tissue. Although nesfatin-1 may have pro-inflammatory and apoptotic properties, the association between plasma nesfatin-1 levels and coronary artery disease (CAD) has not been clarified yet. We investigated plasma nesfatin-1 levels in 302 patients undergoing elective coronary angiography. Of the 302 study patients, CAD was present in 172 (57%), of whom 67 had 1-vessel, 49 had 2-vessel, and 56 had 3-vessel disease. Compared with 130 patients without CAD, 172 with CAD had higher plasma nesfatin-1 levels (median 0.21 vs. 0.17 ng/mL, P < 0.01). A stepwise increase in nesfatin-1 levels was found depending on the number of > 50% stenotic coronary vessels: 0.17 in CAD(−), 0.20 in 1-vessel, 0.21 in 2-vessel, and 0.22 ng/mL in 3-vessel disease (P < 0.05). A high nesfatin-1 level (> 0.19 ng/mL) was found in 43% of patients with CAD(−), 55% of those with 1-vessel, 55% of those with 2-vessel, and 68% of those with 3-vessel disease (P < 0.05). Nesfatin-1 levels significantly correlated with the number of > 50% stenotic coronary segments (r = 0.14, P < 0.02). In multivariate analysis, plasma nesfatin-1 levels were a significant factor for CAD independent of atherosclerotic risk factors. The odds ratio for CAD was 1.71 (95% CI 1.01–2.91) for high nesfatin-1 level of > 0.19 ng/mL (P < 0.05). Thus, plasma nesfatin-1 levels were found to be high in patients with CAD and were associated with CAD independent of atherosclerotic risk factors, suggesting that high nesfatin-1 levels in patients with CAD may play a role in the development of coronary atherosclerosis.

Keywords

Atherosclerosis Biomarker Coronary artery disease Nesfatin-1 

Notes

Funding

This study was supported in part by a grant from Honjo International Scholarship Foundation. Financial funding was also provided in part by Bayer Yakuhin Ltd. and Pfizer Japan Inc.; however, these sponsors had no role in the design, analysis, or interpretation of our study.

Compliance with ethical standards

Conflict of interest

Our study has no conflicts of interest to disclose.

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Copyright information

© Springer Japan KK, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of CardiologyNational Hospital Organization Tokyo Medical CenterTokyoJapan
  2. 2.Endowed Research Department “Food for Health”Ochanomizu UniversityTokyoJapan
  3. 3.Faculty of Regional DesignUtsunomiya UniversityTochigiJapan
  4. 4.Institute of Life Innovation StudiesToyo UniversityGunmaJapan

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