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Heart and Vessels

, Volume 32, Issue 7, pp 790–795 | Cite as

Comparison of 8-frame and 16-frame thallium-201 gated myocardial perfusion SPECT for determining left ventricular systolic and diastolic parameters

  • Satoshi KurisuEmail author
  • Yoji Sumimoto
  • Hiroki Ikenaga
  • Noriaki Watanabe
  • Ken Ishibashi
  • Yoshihiro Dohi
  • Yukihiro Fukuda
  • Yasuki Kihara
Original Article

Abstract

The myocardial perfusion single photon emission computed tomography synchronized with the electrocardiogram (gated SPECT) has been widely used for the assessment of left ventricular (LV) systolic and diastolic functions using Quantitative gated SPECT. The aim of this study was to compare the effects of 8-frame and 16-frame thallium-201 (Tl-201) gated SPECT for determining LV systolic and diastolic parameters. The study population included 42 patients with suspected coronary artery disease who underwent gated SPECT by clinical indication. LV systolic and diastolic parameters were assessed on 8-frame and 16-frame gated SPECT. There were good correlations in end-diastolic volume (r = 0.99, p < 0.001), end-systolic volume (ESV) (r = 0.97, p < 0.001) and ejection fraction (EF) (r = 0.95, p < 0.001) between 8-frame and 16-frame gated SPECT. Bland–Altman plot showed a significant negative slope of −0.08 in EDV indicating a larger difference for larger EDV. Eight-frame gated SPECT overestimated ESV by 2.3 ml, and underestimated EF by −4.2% than 16-frame gated SPECT. There were good correlations in peak filling rate (PFR) (r = 0.87, p < 0.001), one third mean filling rate (r = 0.87, p < 0.001) and time to PFR (r = 0.61, p < 0.001) between 8-frame and 16-frame gated SPECT. Eight-frame gated SPECT underestimated PFR by −0.22 than 16-frame gated SPECT. Eight-frame gated SPECT estimated as much MFR/3 and TPFR as 16-frame gated SPECT. According to the data, the study suggested that 8-frame Tl-201 gated SPECT could underestimate systolic and/or diastolic parameter when compared with 16-frame gated SPECT.

Keywords

Gated SPECT Diastolic function Thallium Ventricular volume 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Japan 2016

Authors and Affiliations

  • Satoshi Kurisu
    • 1
    Email author
  • Yoji Sumimoto
    • 1
  • Hiroki Ikenaga
    • 1
  • Noriaki Watanabe
    • 1
  • Ken Ishibashi
    • 1
  • Yoshihiro Dohi
    • 1
  • Yukihiro Fukuda
    • 1
  • Yasuki Kihara
    • 1
  1. 1.Department of Cardiovascular MedicineHiroshima University Graduate School of Biomedical and Health SciencesHiroshimaJapan

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