Heart and Vessels

, Volume 30, Issue 5, pp 580–586 | Cite as

Impact of combined lipid lowering with blood pressure control on coronary plaque regression: rationale and design of MILLION study

  • Masa-aki Kawashiri
  • Kenji Sakata
  • Tadatsugu Gamou
  • Honin Kanaya
  • Kenji Miwa
  • Kosei Ueda
  • Toshinori Higashikata
  • Sumio Mizuno
  • Ichiro Michishita
  • Masanobu Namura
  • Yutaka Nitta
  • Shoji Katsuda
  • Kazuyasu Okeie
  • Hiroaki Hirase
  • Hayato Tada
  • Katsuharu Uchiyama
  • Tetsuo Konno
  • Kenshi Hayashi
  • Hidekazu Ino
  • Keisuke Nagase
  • Mitsuyasu Terashima
  • Masakazu Yamagishi
Original Article

Abstract

A line of epidemiological studies suggests that the accumulation of coronary risk factors promotes the progression of coronary atherosclerosis. Recent clinical studies showed that aggressive low-density lipoprotein (LDL) cholesterol-lowering therapy using statins could regress coronary atheroma and reduce major cardiovascular events. Additionally, therapy that controlled amlodipine-based blood pressure reduced major cardiovascular events in patients with hypertension compared with an atenolol-based regimen. An open-label randomized multicenter study is primarily planned to evaluate the changes in coronary atheroma volume using intravascular ultrasonography 18–24 months after intensive lowering of LDL-cholesterol and blood pressure compared with a standard therapy indicated by current guidelines in Japanese patients with coronary artery disease (CAD). The secondary endpoints include changes in serum lipid levels, inflammatory markers, glucose markers and blood pressure. In total, 100 subjects with CAD who are undergoing percutaneous coronary intervention will be tested. The MILLION study will provide new evidence and therapeutic standards for the prevention of CAD in Japanese patients by controlling both LDL-C levels and blood pressure.

Keywords

Amlodipine Atorvastatin Coronary plaque volume Intravascular ultrasonography (IVUS) 

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Copyright information

© Springer Japan 2014

Authors and Affiliations

  • Masa-aki Kawashiri
    • 1
  • Kenji Sakata
    • 1
  • Tadatsugu Gamou
    • 1
  • Honin Kanaya
    • 2
  • Kenji Miwa
    • 2
  • Kosei Ueda
    • 3
  • Toshinori Higashikata
    • 3
  • Sumio Mizuno
    • 4
  • Ichiro Michishita
    • 5
  • Masanobu Namura
    • 6
  • Yutaka Nitta
    • 7
  • Shoji Katsuda
    • 7
  • Kazuyasu Okeie
    • 8
  • Hiroaki Hirase
    • 9
  • Hayato Tada
    • 1
  • Katsuharu Uchiyama
    • 1
  • Tetsuo Konno
    • 1
  • Kenshi Hayashi
    • 1
  • Hidekazu Ino
    • 1
  • Keisuke Nagase
    • 10
  • Mitsuyasu Terashima
    • 11
  • Masakazu Yamagishi
    • 1
  1. 1.Division of Cardiovascular MedicineKanazawa University Graduate School of MedicineKanazawaJapan
  2. 2.Department of CardiologyIshikawa Prefectural Central HospitalKanazawaJapan
  3. 3.Department of Internal MedicineKomatsu Municipal HospitalKomatsuJapan
  4. 4.Department of CardiologyFukui Cardiovascular CenterFukuiJapan
  5. 5.Department of Internal MedicineYokohama Sakae Kyosai HospitalYokohamaJapan
  6. 6.Department of CardiologyKanazawa Cardiovascular HospitalKanazawaJapan
  7. 7.Department of CardiologyToyama Red Cross HospitalToyamaJapan
  8. 8.Department of CardiologyKoseiren Takaoka HospitalTakaokaJapan
  9. 9.Department of Internal MedicineTakaoka Municipal HospitalTakaokaJapan
  10. 10.Division of Medical SciencesKanazawa University Graduate School of MedicineKanazawaJapan
  11. 11.Cardiovascular Imaging CenterToyohashiJapan

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