Heart and Vessels

, Volume 30, Issue 4, pp 469–476 | Cite as

Lower 1,5-anhydroglucitol is associated with denovo coronary artery disease in patients at high cardiovascular risk

  • Takayuki Fujiwara
  • Masashi Yoshida
  • Hodaka Yamada
  • Takunori Tsukui
  • Tomohiro Nakamura
  • Kenichi Sakakura
  • Hiroshi Wada
  • Kenshiro Arao
  • Takuji Katayama
  • Hiroshi Funayama
  • Yoshitaka Sugawara
  • Takeshi Mitsuhashi
  • Masafumi Kakei
  • Shin-ichi Momomura
  • Junya Ako
Original Article

Abstract

Postprandial hyperglycemia is a risk factor for cardiovascular disease and mortality. Serum 1,5-anhydroglucitol (1,5-AG) level is an useful clinical marker of glucose metabolism which reflects postprandial hyperglycemia more robustly compared to hemoglobin A1c (HbA1c). Relationship between serum 1,5-AG level and cardiovascular disease has been reported; however, comparison between HbA1c and 1,5-AG as markers of cardiovascular disease was not performed. We included 227 consecutive patients who underwent coronary angiography meeting the following inclusion criteria: (1) patients who had no history of coronary artery disease (CAD); (2) patients without acute coronary syndrome; (3) patients without poorly controlled diabetes mellitus; (4) patients without anemia, liver dysfunction, acute, and chronic renal failure and malnutrition; and (5) patients without adhibition of acarbose or Chinese herbal medicine. We measured HbA1c, glycoalbumin, and 1,5-AG. Serum 1,5-AG was significantly lower in patients with CAD (16.6 ± 8.50 vs. 21.1 ± 7.97 μg/ml, P < 0.001). Multivariable logistic regression analysis showed decrease in serum 1,5-AG was independently associated with the presence of denovo CAD (0.93, 95 % CI 0.88–0.98, P = 0.006). Serum 1,5-AG was also independently associated with the presence of denovo CAD in patients without diabetes mellitus (0.94, 95 % CI 0.88–0.99, P = 0.046). In conclusion, lower serum 1,5-AG was associated with the presence of denovo CAD. Serum 1,5-AG may identify high cardiovascular risk patients for denovo CAD in both diabetic and non-diabetic patients.

Keywords

1,5-Anhydroglucitol Coronary artery disease Postprandial hyperglycemia Diabetes mellitus 

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Copyright information

© Springer Japan 2014

Authors and Affiliations

  • Takayuki Fujiwara
    • 1
  • Masashi Yoshida
    • 2
  • Hodaka Yamada
    • 2
  • Takunori Tsukui
    • 1
  • Tomohiro Nakamura
    • 1
  • Kenichi Sakakura
    • 1
  • Hiroshi Wada
    • 1
  • Kenshiro Arao
    • 1
  • Takuji Katayama
    • 1
  • Hiroshi Funayama
    • 1
  • Yoshitaka Sugawara
    • 1
  • Takeshi Mitsuhashi
    • 1
  • Masafumi Kakei
    • 2
  • Shin-ichi Momomura
    • 1
  • Junya Ako
    • 3
  1. 1.Department of Cardiovascular Medicine, Saitama Medical CenterJichi Medical UniversitySaitamaJapan
  2. 2.Department of Endocrinology and Metabolism, Saitama Medical CenterJichi Medical UniversitySaitamaJapan
  3. 3.Department of Cardiovascular MedicineKitasato UniversityTokyoJapan

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