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Heart and Vessels

, Volume 30, Issue 2, pp 154–161 | Cite as

High HDL cholesterol level after treatment with pitavastatin is an important factor for regression in carotid intima–media thickness

  • Kenji Okumura
  • Hideto Tsukamoto
  • Hideyuki Tsuboi
  • Haruo Hirayama
  • Haruo Kamiya
  • Masato Watarai
  • Ryoji Ishiki
  • Toyoaki Murohara
  • on behalf of the Samurai Study Investigators
Original Article

Abstract

This study is a prospective multicenter study designed to investigate the effects of lipid-lowering therapy with pitavastatin on atherosclerotic plaque in patients with coronary heart disease, and to determine which factor is more closely associated with plaque regression. Participants (n = 63) were treated with pitavastatin for 12 months, and the carotid intima–media thickness (IMT) was measured by ultrasound before and after treatment. Mean IMT slightly but significantly decreased (from 0.99 ± 0.33 to 0.94 ± 0.28 mm for overall, P = 0.01) regardless of the presence of pretreatment with other statins. There were no significant relations with hs-CRP, malondialdehyde-LDL, LDL cholesterol, and smaller LDL cholesterol levels despite their decrease by pitavastatin. Decreases in mean IMT were observed significantly more frequently in subjects with high on-treatment HDL cholesterol levels than with low HDL cholesterol levels (P = 0.017). The change in mean IMT tended to be inversely correlated with increments in HDL cholesterol and apolipoprotein A-I. The IMT regression was more often observed in the absence of diabetes and metabolic syndrome. In conclusion, we demonstrated that treatment with pitavastatin attenuated atherosclerotic plaque. This effect was associated with the level of HDL cholesterol, and was stronger in the absence of diabetes and metabolic syndrome in our ischemic heart disease patients.

Keywords

Intima–media thickness Pitavastatin HDL cholesterol Lipoproteins 

Notes

Acknowledgments

We thank all participants of this Secondary SAMURAI Study (Statin therapy against multi-lipoprotein profiling and atherosclerosis) for their co-operation and patience throughout the trial. The Department of Cardiology of the Nagoya University Graduate School of Medicine received an unrestricted research grant support from KOWA Pharmaceutical Co. Ltd. (Tokyo, Japan).

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Copyright information

© Springer Japan 2014

Authors and Affiliations

  • Kenji Okumura
    • 1
  • Hideto Tsukamoto
    • 1
  • Hideyuki Tsuboi
    • 2
  • Haruo Hirayama
    • 3
  • Haruo Kamiya
    • 4
  • Masato Watarai
    • 5
  • Ryoji Ishiki
    • 6
  • Toyoaki Murohara
    • 7
  • on behalf of the Samurai Study Investigators
  1. 1.Department of CardiologyToki Municipal General HospitalTokiJapan
  2. 2.Department of CardiologyOgaki Municipal HospitalOgakiJapan
  3. 3.Department of CardiologyNagoya Daini Red Cross HospitalNagoyaJapan
  4. 4.Department of CardiologyJapanese Red Cross Nagoya First HospitalNagoyaJapan
  5. 5.Cardiovascular CenterAnjo Kosei HospitalAnjoJapan
  6. 6.Department of Internal MedicineToyota Memorial HospitalToyotaJapan
  7. 7.Department of CardiologyNagoya University Graduate School of MedicineNagoyaJapan

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