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Heart and Vessels

, Volume 30, Issue 1, pp 28–35 | Cite as

Evaluation of coronary artery disease and cardiac morphology and function in patients with hypertrophic cardiomyopathy, using cardiac computed tomography

  • Satoshi OkayamaEmail author
  • Tsunenari Soeda
  • Rika Kawakami
  • Yasuhiro Takami
  • Satoshi Somekawa
  • Tomoya Ueda
  • Yu Sugawara
  • Takaki Matsumoto
  • Ji Hee Sung
  • Taku Nishida
  • Shiro Uemura
  • Yoshihiko Saito
Original Article

Abstract

Coronary artery disease and cardiac morphology and function were evaluated in 51 patients with hypertrophic cardiomyopathy (HCM), without typical chest pain, using cardiac computed tomography (CT). This study investigated the prevalence of coronary artery disease, the indicators of obstructive coronary stenosis, and the magnitude of left ventricular (LV) hypertrophy. The patients’ mean coronary artery calcium score was 198.8 ± 312.0 and was positively correlated with the number of coronary risk factors (r = 0.32; P < 0.05). Of the 51 patients with HCM, 42 (82.4 %) had some degree of stenosis and 8 (15.7 %) had obstructive stenosis. Noncalcified and mixed plaques were detected in 14 (27.5 %) and 11 (21.6 %) patients, respectively. Multivariate logistic regression revealed that diabetes was an independent indicator of the presence of obstructive stenosis in HCM patients. Multivariate linear regression revealed that low estimated glomerular filtration rates and high triglyceride concentrations were independent indicators of higher LV mass indexes. In conclusion, cardiac CT revealed that coronary artery disease was common among patients with HCM. The presence of obstructive coronary stenosis and the magnitude of LV hypertrophy were related to the presence of diabetes, triglyceride levels, and estimated glomerular filtration rate.

Keywords

Hypertrophic cardiomyopathy Coronary artery disease Computed tomography Diabetes 

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Copyright information

© Springer Japan 2013

Authors and Affiliations

  • Satoshi Okayama
    • 1
    Email author
  • Tsunenari Soeda
    • 1
  • Rika Kawakami
    • 1
  • Yasuhiro Takami
    • 1
  • Satoshi Somekawa
    • 1
  • Tomoya Ueda
    • 1
  • Yu Sugawara
    • 1
  • Takaki Matsumoto
    • 1
  • Ji Hee Sung
    • 2
  • Taku Nishida
    • 1
  • Shiro Uemura
    • 1
  • Yoshihiko Saito
    • 1
  1. 1.First Department of Internal MedicineNara Medical UniversityNaraJapan
  2. 2.Department of CardiologyYamato-Kashihara HospitalNaraJapan

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