Heart and Vessels

, Volume 28, Issue 4, pp 480–489 | Cite as

L/N-type calcium channel blocker cilnidipine reduces plasma aldosterone, albuminuria, and urinary liver-type fatty acid binding protein in patients with chronic kidney disease

  • Masanori AbeEmail author
  • Noriaki Maruyama
  • Hiroko Suzuki
  • Atsushi Inoshita
  • Yoshinori Yoshida
  • Kazuyoshi Okada
  • Masayoshi Soma
Original Article


Cilnidipine inhibits both L- and N-type calcium channels and has been shown to dilate efferent arterioles as effectively as afferent arterioles. We conducted an open-label, randomized trial to compare the effects of cilnidipine against those of amlodipine on blood pressure (BP), albuminuria, and plasma aldosterone concentration in hypertensive patients with mild- to moderate-stage chronic kidney disease. Patients with BP ≥130/80 mmHg, an estimated glomerular filtration rate of 90–30 ml/min/1.73 m2, and albuminuria ≥30 mg/g, despite treatment with the maximum recommended dose of angiotensin II receptor blockers, were randomly assigned to two groups. Patients received either 10 mg/day cilnidipine (increased to 20 mg/day; n = 35) or 2.5 mg/day amlodipine (increased to 5 mg/day; n = 35). After 48 weeks of treatment, a significant and comparable reduction in systolic and diastolic BP was observed in both groups. The percent reduction in the urinary albumin to creatinine ratio and liver-type fatty acid binding protein (L-FABP) in the cilnidipine group was significantly greater than in the amlodipine group. Although plasma renin activity did not differ between the two groups, the plasma aldosterone level was significantly decreased in the cilnidipine group. Cilnidipine therefore appears to reduce albuminuria, urinary L-FABP, and plasma aldosterone levels more than amlodipine, and these effects are independent of BP reduction.


Albuminuria Aldosterone Chronic kidney disease Cilnidipine Hypertension N-type calcium channel blocker 


Conflict of interest

The authors report no conflicts of interest.


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Copyright information

© Springer 2012

Authors and Affiliations

  • Masanori Abe
    • 1
    Email author
  • Noriaki Maruyama
    • 1
  • Hiroko Suzuki
    • 1
  • Atsushi Inoshita
    • 1
  • Yoshinori Yoshida
    • 1
  • Kazuyoshi Okada
    • 1
  • Masayoshi Soma
    • 1
    • 2
  1. 1.Division of Nephrology, Hypertension and Endocrinology, Department of Internal MedicineNihon University School of MedicineTokyoJapan
  2. 2.Division of General Medicine, Department of Internal MedicineNihon University School of MedicineTokyoJapan

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