Heart and Vessels

, Volume 27, Issue 2, pp 208–215 | Cite as

Advanced glycation end products in myocardial reperfusion injury

  • Peter Celec
  • Július Hodosy
  • Peter Jáni
  • Pavol Janega
  • Matúš Kúdela
  • Marta Kalousová
  • Johana Holzerová
  • Vojtech Parrák
  • Lukáč Halčák
  • Tomáš Zima
  • Martin Braun
  • Ivan Pecháň
  • Ján Murín
  • Katarína Šebeková
Original Article

Abstract

Advanced glycation end products (AGEs) are associated with cardiovascular diseases. Whether the AGE levels change during myocardial reperfusion injury is currently unknown. The aim of our study was to investigate the dynamics of AGEs in myocardial reperfusion injury and to discuss potential reasons for these changes. The dynamics of AGEs, pentosidine and neopterin in the plasma of patients with acute myocardial infarction (AMI) treated using thrombolysis (n = 40) were analyzed. In addition, AGEs were measured in patients with open heart surgery (n = 12) and rabbits with induced AMI (n = 9). In all three studies of myocardial reperfusion injury, a significant decrease of AGEs was observed (by 26 ± 19% in patients with AMI, by 23 ± 14% in patients with open heart surgery and by 39 ± 10% in rabbits with AMI within 1 day of reperfusion; p < 0.05 in all studies). In additional studies, an association between lower AGEs and an activated immune system (R2 = 0.09; p < 0.01) and fasting (decrease by 38%; p < 0.01) was shown. AGEs decrease in reperfusion injury of the heart. Indices pointing towards the involvement of immune system activation and fasting are presented. Further studies focusing on the underlying mechanism and on the clinical value of the observed dynamics of AGEs are needed.

Keywords

Carbonyl stress Pentosidine Acute myocardial infarction Neopterin 

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Copyright information

© Springer 2011

Authors and Affiliations

  • Peter Celec
    • 1
    • 2
    • 3
  • Július Hodosy
    • 1
    • 4
    • 5
  • Peter Jáni
    • 6
  • Pavol Janega
    • 7
    • 8
  • Matúš Kúdela
    • 9
  • Marta Kalousová
    • 10
  • Johana Holzerová
    • 2
  • Vojtech Parrák
    • 5
  • Lukáč Halčák
    • 11
  • Tomáš Zima
    • 10
  • Martin Braun
    • 12
  • Ivan Pecháň
    • 13
  • Ján Murín
    • 5
  • Katarína Šebeková
    • 1
  1. 1.Institute of Molecular BiomedicineComenius UniversityBratislavaSlovakia
  2. 2.Institute of PathophysiologyComenius UniversityBratislavaSlovakia
  3. 3.Department of Molecular BiologyComenius UniversityBratislavaSlovakia
  4. 4.Institute of PhysiologyComenius UniversityBratislavaSlovakia
  5. 5.University HospitalComenius UniversityBratislavaSlovakia
  6. 6.Department of PathologyHospital KrnovKrnovCzech Republic
  7. 7.Institute of PathologyComenius UniversityBratislavaSlovakia
  8. 8.Institute of Normal and Pathological Physiology, Slovak Academy of SciencesBratislavaSlovakia
  9. 9.Department of ZoologyComenius UniversityBratislavaSlovakia
  10. 10.Institute of Clinical Biochemistry and Laboratory DiagnosticsFirst Faculty of Medicine, Charles University in Prague and General University Hospital in PraguePragueCzech Republic
  11. 11.Institute of Chemistry, Biochemistry and Clinical BiochemistryComenius UniversityBratislavaSlovakia
  12. 12.Institute of RheumatologyPragueCzech Republic
  13. 13.National Institute of Cardiovascular DiseasesBratislavaSlovakia

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