Heart and Vessels

, Volume 26, Issue 6, pp 572–581

Utility of myocardial fractional flow reserve for prediction of restenosis following sirolimus-eluting stent implantation

  • Hideshi Ishii
  • Toru Kataoka
  • Yoshiki Kobayashi
  • Takara Tsumori
  • Hiroaki Takeshita
  • Ryo Matsumoto
  • Nobuyuki Shirai
  • Hiroki Nishioka
  • Takao Hasegawa
  • Shinji Nakata
  • Yoshihisa Shimada
  • Shoichi Ehara
  • Takashi Muro
  • Minoru Yoshiyama
Original Article

DOI: 10.1007/s00380-010-0105-1

Cite this article as:
Ishii, H., Kataoka, T., Kobayashi, Y. et al. Heart Vessels (2011) 26: 572. doi:10.1007/s00380-010-0105-1

Abstract

Drug-eluting stents reduce restenosis due to neointimal growth suppression. Considering long-term outcomes, it is both difficult and important to predict drug-eluting stent restenosis. Thus, this study was designed to examine the utility of myocardial fractional flow reserve (FFR) as a predictor of sirolimus-eluting stent (SES) restenosis. Thirty-three patients (35 lesions) were enrolled. Upon completion of SES implantation, FFR was obtained under hyperemia. At 8 months of follow-up, coronary angiography revealed that five lesions had restenosis. Percent diameter stenosis (restenosis 68.7 ± 12.8% vs. non-restenosis 68.7 ± 12.4%, p = 0.78) and lesion length (restenosis 15.8 ± 9.4 mm vs. non-restenosis 14.4 ± 9.2 mm, p = 0.60) were similar. At post-intervention, percent diameter stenosis (restenosis 16.4 ± 6.1% vs. non-restenosis 14.0 ± 7.4%, p = 0.48) and minimum stent area (restenosis 6.01 ± 1.08 mm2 vs. non-restenosis 6.27 ± 1.85 mm2, p = 0.92) were also equivalent. However, proximal edge lumen area was smaller (restenosis 4.24 ± 1.40 mm2 vs. non-restenosis 7.73 ± 2.64 mm2, p = 0.004) and FFR was lower in the restenosis group (restenosis 0.81 ± 0.12 vs. non-restenosis 0.92 ± 0.06, p = 0.029). SES patients with restenosis had a lower FFR post stent deployment, suggesting the decreased FFR may be a useful predictor for SES restenosis.

Keywords

Cardiovascular diseases Restenosis Drug-eluting stents Coronary physiology Myocardial fractional flow reserve 

Copyright information

© Springer 2010

Authors and Affiliations

  • Hideshi Ishii
    • 1
  • Toru Kataoka
    • 2
  • Yoshiki Kobayashi
    • 3
  • Takara Tsumori
    • 2
  • Hiroaki Takeshita
    • 4
  • Ryo Matsumoto
    • 2
  • Nobuyuki Shirai
    • 2
  • Hiroki Nishioka
    • 5
  • Takao Hasegawa
    • 2
  • Shinji Nakata
    • 2
  • Yoshihisa Shimada
    • 6
  • Shoichi Ehara
    • 2
  • Takashi Muro
    • 2
  • Minoru Yoshiyama
    • 2
  1. 1.Department of CardiologyHigashisumiyoshi Morimoto HospitalOsakaJapan
  2. 2.Department of Internal Medicine and Cardiology, Graduate School of MedicineOsaka City UniversityOsakaJapan
  3. 3.Department of CardiologyMoriguchi Ikuno Memorial HospitalMoriguchiJapan
  4. 4.Division of CardiologyTsukazaki HospitalHimejiJapan
  5. 5.Department of CardiologyIshikiriseiki HospitalHigashiosakaJapan
  6. 6.Department of CardiologyShiroyama HospitalHabikinoJapan

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