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Enjoying hobbies is related to desirable cardiovascular effects

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Abstract

An unhealthy lifestyle can increase the risk of cardiovascular disease. However, the mechanism by which lifestyle influences the development of cardiovascular disease remains unclear. Since coronary endothelial function is a predictor of cardiovascular prognosis, the goal of this study was to characterize the effect of enjoying hobbies on coronary endothelial function and cardiovascular outcomes. A total of 121 consecutive patients (76 men, 45 women) with almost normal coronary arteries underwent Doppler flow study of the left anterior descending coronary artery following sequential administration of papaverine, acetylcholine, and nitroglycerin. On the basis of responses to questionnaires, patients were divided into two groups; the Hobby group (n = 71) who enjoyed hobbies, and the Non-hobby group (n = 50) who had no hobbies. Cardiovascular outcomes were assessed at long-term follow-up using medical records or questionnaire surveys for major adverse cardiovascular events (MACE).The average follow-up period was 916 ± 515 days. There were no significant differences in demographics when comparing the two groups. The percent change in coronary blood flow and coronary artery diameter induced by acetylcholine was significantly greater in the Hobby group than in the Non-hobby group (49% ± 77% vs 25% ± 37%, P < 0.05, 4% ± 13% vs −3% ± 20%, P < 0.05, respectively). The MACE rate was significantly lower in the Hobby group than in the Non-hobby group (P < 0.01). Enjoyment of hobbies was the only independent predictor of MACE (odds ratio 8.1 [95% confidence interval 1.60, 41.90], P = 0.01) among the variables tested. In the early stages of arteriosclerosis, enjoying hobbies may improve cardiovascular outcomes via its favorable effects on coronary endothelial function.

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References

  1. Kubo SH, Rector TS, Bank AJ, Williams RE, Heifetz SM (1991) Endothelium-dependent vasodilation is attenuated in patients with heart failure. Circulation 84:1589–1596

    CAS  PubMed  Google Scholar 

  2. Drexler H, Hayoz D, Münzel T, Hornig B, Just H, Brunner HR, Zelis R (1992) Endothelial function in chronic congestive heart failure. Am J Cardiol 69:1596–1601

    Article  CAS  PubMed  Google Scholar 

  3. Hambrecht R, Fiehn E, Weigl C, Gielen S, Hamann C, Kaiser R, Yu J, Adams V, Niebauer J, Schuler G (1998) Regular physical exercise corrects endothelial dysfunction and improves exercise capacity in patients with chronic heart failure. Circulation 98: 2709–2715

    CAS  PubMed  Google Scholar 

  4. Vona M, Rossi A, Capodaglio P, Rizzo S, Servi P, De Marchi M, Cobelli F (2004) Impact of physical training and detraining on endothelium-dependent vasodilation in patients with recent acute myocardial infarction. Am Heart J 147:1039–1046

    Article  CAS  PubMed  Google Scholar 

  5. Gokce N, Keaney JF Jr, Hunter LM, Watkins MT, Nedeljkovic ZS, Menzoian JO, Vita JA (2003) Predictive value of noninvasively determined endothelial dysfunction for long-term cardiovascular events in patients with peripheral vascular disease. J Am Coll Cardiol 41:1769–1775

    Article  PubMed  Google Scholar 

  6. Schächinger V, Britten MB, Zeiher AM (2000) Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation 101:1899–1906

    PubMed  Google Scholar 

  7. Lisspers J, Sundin O, Ohman A, Hofman-Bang C, Rydén L, Nygren A (2005) Long-term effects of lifestyle behavior change in coronary artery disease: effects on recurrent coronary events after percutaneous coronary intervention. Health Psychol 24:41–48

    Article  PubMed  Google Scholar 

  8. Wannamethee SG, Shaper AG, Walker M, Ebrahim S (1998) Lifestyle and 15-year survival free of heart attack, stroke, and diabetes in middle-aged British men. Arch Intern Med 158:2433–2440

    Article  CAS  PubMed  Google Scholar 

  9. Nielsen NR, Kristensen TS, Schnohr P, Grønbaek M (2008) Perceived stress and cause-specific mortality among men and women: results from a prospective cohort study. Am J Epidemiol 168: 481–491

    Article  PubMed  Google Scholar 

  10. Sivasankaran S, Pollard-Quintner S, Sachdeva R, Pugeda J, Hoq SM, Zarich SW (2006) The effect of a six-week program of yoga and meditation on brachial artery reactivity: do psychosocial interventions affect vascular tone? Clin Cardiol 29:393–398

    Article  PubMed  Google Scholar 

  11. Hamasaki S, Al Suwaidi J, Higano ST, Miyauchi K, Holmes DR Jr, Lerman A (2000) Attenuated coronary flow reserve and vascular remodeling in patients with hypertension and left ventricular hypertrophy. J Am Coll Cardiol 35:1654–1660

    Article  CAS  PubMed  Google Scholar 

  12. Nishimura RA, Lerman A, Chesebro JH, Ilstrup DM, Hodge DO, Higano ST, Holmes DR Jr, Tajik AJ (1995) Epicardial vasomotor responses to acetylcholine are not predicted by coronary atherosclerosis as assessed by intracoronary ultrasound. J Am Coll Cardiol 26:41–49

    Article  CAS  PubMed  Google Scholar 

  13. Hasdai D, Gibbons RJ, Holmes DR Jr, Higano ST, Lerman A (1997) Coronary endothelial dysfunction in humans is associated with myocardial perfusion defects. Circulation 96:3390–3395

    CAS  PubMed  Google Scholar 

  14. Ninomiya Y, Hamasaki S, Saihara K, Ishida S, Kataoka T, Ogawa M, Orihara K, Oketani N, Fukudome T, Okui H, Ichiki T, Shinsato T, Kubozono T, Mizoguchi E, Ichiki H, Tei C (2008) Comparison of effect between nitrates and calcium channel antagonist on vascular function in patients with normal or mildly diseased coronary arteries. Heart Vessels 23(2):83–90

    Article  PubMed  Google Scholar 

  15. Egashira K, Inou T, Hirooka Y, Kai H, Sugimachi M, Suzuki S, Kuga T, Urabe Y, Takeshita A (1993) Effects of age on endothelium-dependent vasodilation of resistance coronary artery by acetylcholine in humans. Circulation 88:77–81

    CAS  PubMed  Google Scholar 

  16. Doucette JW, Corl PD, Payne HM, Flynn AE, Goto M, Nassi M, Segal J (1992) Validation of a Doppler guide wire for intravascular measurement of coronary artery flow velocity. Circulation 85: 1899–1911

    CAS  PubMed  Google Scholar 

  17. Pike JL, Smith TL, Hauger RL, Nicassio PM, Patterson TL, McClintick J, Costlow C, Irwin MR (1997) Chronic life stress alters sympathetic, neuroendocrine, and immune responsivity to an acute psychological stressor in humans. Psychosom Med 59:447–457

    CAS  PubMed  Google Scholar 

  18. Kawano TA, Aoki N, Homori M, Kawano K, Maki A, Kimura M, Yanagisawa A, Ohsaki T, Takahashi R, Shiohara T, Ishikawa K, Yoshino H (2000) Mental stress and physical exercise increase platelet-dependent thrombin generation. Heart Vessels 15: 280–288

    Article  CAS  PubMed  Google Scholar 

  19. Suwaidi JA, Hamasaki S, Higano ST, Nishimura RA, Holmes DR Jr, Lerman A (2000) Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction. Circulation 101:948–954

    CAS  PubMed  Google Scholar 

  20. Noris M, Morigi M, Donadelli R, Aiello S, Foppolo M, Todeschini M, Orisio S, Remuzzi G, Remuzzi A (1995) Nitric oxide synthesis by cultured endothelial cells is modulated by flow conditions. Circ Res 76:536–543

    CAS  PubMed  Google Scholar 

  21. Sessa WC, Pritchard K, Seyedi N, Wang J, Hintze TH (1994) Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression. Circ Res 74:349–353

    CAS  PubMed  Google Scholar 

  22. Hambrecht R, Adams V, Erbs S, Linke A, Kränkel N, Shu Y, Baither Y, Gielen S, Thiele H, Gummert JF, Mohr FW, Schuler G (2003) Regular physical activity improves endothelial function in patients with coronary artery disease by increasing Phosphorylation of endothelial nitric oxide synthase. Circulation 107:3152–3158

    Article  CAS  PubMed  Google Scholar 

  23. Konlaan BB, Bygren LO, Johansson SE (2000) Visiting the cinema, concerts, museums or art exhibitions as determinant of survival: a Swedish fourteen-year cohort follow-up. Scand J Public Health 28:174–178

    CAS  PubMed  Google Scholar 

  24. Takahashi T, Matsushita H (2006) Long-term effects of music therapy on elderly with moderate/severe dementia. J Music Ther 43:317–333

    PubMed  Google Scholar 

  25. Giltay EJ, Kamphuis MH, Kalmijn S, Zitman FG, Kromhout D (2006) Dispositional optimism and the risk of cardiovascular death: the Zutphen Elderly Study. Arch Intern Med 166:431–436

    Article  PubMed  Google Scholar 

  26. Al-Khalili F, Janszky I, Andersson A, Svane B, Schenck-Gustafsson K (2007) Physical activity and performance predict long-term prognosis in middle-aged women surviving acute coronary syndrome. J Intern Med 261:178–187

    Article  CAS  PubMed  Google Scholar 

  27. Warren JB, Loi RK (1995) Captopril increases skin microvascular blood flow secondary to bradykinin, nitric oxide, and prostaglandins. FASEB J 9:411–418

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan

    Keishi Saihara, Shuichi Hamasaki, Sanemasa Ishida, Tetsuro Kataoka, Akiko Yoshikawa, Koji Orihara, Masakazu Ogawa, Naoya Oketani, Tsuyoshi Fukudome, Nobuhiko Atsuchi, Takuro Shinsato, Hideki Okui, Takuro Kubozono, Hitoshi Ichiki, So Kuwahata, Etsuko Mizoguchi, Shoji Fujita, Takuro Takumi, Yuichi Ninomiya, Kaai Tomita & Chuwa Tei

Authors
  1. Keishi Saihara
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  2. Shuichi Hamasaki
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  3. Sanemasa Ishida
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  4. Tetsuro Kataoka
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  5. Akiko Yoshikawa
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  6. Koji Orihara
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  7. Masakazu Ogawa
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  8. Naoya Oketani
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  9. Tsuyoshi Fukudome
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  10. Nobuhiko Atsuchi
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  11. Takuro Shinsato
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  12. Hideki Okui
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  13. Takuro Kubozono
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  14. Hitoshi Ichiki
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  15. So Kuwahata
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  16. Etsuko Mizoguchi
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  17. Shoji Fujita
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  18. Takuro Takumi
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  19. Yuichi Ninomiya
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  20. Kaai Tomita
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  21. Chuwa Tei
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Corresponding author

Correspondence to Shuichi Hamasaki.

Additional information

A portion of this study was presented at the 56th American College of Cardiology Meeting, 2007.

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Saihara, K., Hamasaki, S., Ishida, S. et al. Enjoying hobbies is related to desirable cardiovascular effects. Heart Vessels 25, 113–120 (2010). https://doi.org/10.1007/s00380-009-1173-y

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  • DOI: https://doi.org/10.1007/s00380-009-1173-y

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