Heart and Vessels

, Volume 23, Issue 5, pp 295–300 | Cite as

Carotid intima-media thickness in pre-and postmenopausal women with suspected coronary artery disease

  • Anna Kablak-ZiembickaEmail author
  • Tadeusz Przewlocki
  • Wieslawa Tracz
  • Piotr Pieniazek
  • Piotr Musialek
  • Andrzej Sokolowski
  • Rafal Drwila
  • Daniel Rzeznik
Original Article


Carotid intima-media thickness (CIMT) is an early marker of coronary artery disease (CAD). This study aimed to evaluate CIMT value for CAD prediction in pre-and postmenopausal women referred for coronary angiography with angina-like symptoms and a positive result of the treadmill test. The study comprised 321 women referred for coronary angiography with symptoms suggesting CAD. Carotid intima-media thickness was measured in common, bifurcation, and internal carotid artery, and expressed as the mean maximum value. Coronary angiography showed coronary stenosis ≥50% in 211 (65.7%) women, including 27 with regular menses (47.3 ± 3.4 years) and 184 postmenopausal (65.8 ± 7.2 years). Normal coronary arteries were found in 110 women: 17 (47.3 ± 4.9 years) with regular menses and 93 postmenopausal (64.3 ± 6.5 years). The highest CIMT values were found in postmenopausal CAD women (1.360 ± 0.32 mm), as compared to premenopausal with CAD (1.178 ± 0.36 mm, P = 0.005), pre-(0.860 ± 0.23 mm, P < 0.001) and postmenopausal (1.022 ± 0.30 mm, P < 0.001) women without CAD. Carotid intima-media thickness (P < 0.001), hyperlipidemia (P = 0.018), and myocardial infarction (P < 0.001), but not menopause itself or the number of years since menses cessation, were found to be independent CAD predictors. By receiver operating characteristic calculation, the mean maximum CIMT cut-off values discriminating CAD were lower in premenopausal (≥0.933 mm) than in postmenopausal women (≥1.075 mm; P < 0.05) resulting in similar sensitivity (85.2% and 82.6%) and specificity (70.6% and 69.9%). Carotid intima-media thickness is a strong CAD predictor in both pre-and postmenopausal women, in contrast to the menopausal status.

Key words

Premenopausal women Postmenopausal women Coronary artery disease Carotid intima-media thickness 


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Copyright information

© Springer Japan 2008

Authors and Affiliations

  • Anna Kablak-Ziembicka
    • 1
    Email author
  • Tadeusz Przewlocki
    • 1
  • Wieslawa Tracz
    • 1
  • Piotr Pieniazek
    • 1
  • Piotr Musialek
    • 1
  • Andrzej Sokolowski
    • 2
  • Rafal Drwila
    • 1
  • Daniel Rzeznik
    • 1
  1. 1.Department of Cardiac and Vascular Diseases, Institute of Cardiology, Collegium MedicumJagiellonian UniversityKrakowPoland
  2. 2.Department of StatisticsCracow University of EconomicsKrakowPoland

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