Heart and Vessels

, Volume 18, Issue 4, pp 188–192 | Cite as

Metoprolol, a Β-1 selective blocker, can be used safely in coronary artery disease patients with chronic obstructive pulmonary disease

  • Ahmet Çamsarı
  • Serpil Arıkan
  • Candan Avan
  • Deniz Kaya
  • Hasan Pekdemir
  • Dilek ÇiÇek
  • Ahmet Kıykım
  • Kerem Sezer
  • Necdet AkkuŞ
  • Mehmet Alkan
  • Sinan Aydogˇdu
ORIGINAL ARTICLE

Abstract

The coexistence of coronary artery disease (CAD) and chronic obstructive pulmonary disease (COPD) is frequent because of common etiological factors. Β-Blockers remain underutilized in patients with CAD who also have COPD. This study was performed to evaluate the safety of Β-1 selective blocker agents in CAD patients with COPD. Fifty patients (aged 57.3 ± 10.1 years) were enrolled in this study; 27 patients received metoprolol CR (controlled release), and 23 received metoprolol (conventional). The patients were stratified according to the severity of COPD (21 severe, 21 moderate, and 8 mild), started on metoprolol CR or conventional metoprolol, and titrated up to the maximum tolerated dose. The clinical controls were done during the first week and then at the first and third month. Patients received a mean total daily dose of 92.5 ± 18 mg of metoprolol CR or 189 ± 36.7 mg of metoprolol. Seven patients could not receive the maximum dose. There was no significant decrease in forced expiratory volume in 1 s (FEV1) in either group (basal vs last FEV1: 54.5% ± 13.4% vs 54.3% ± 13% in the metoprolol CR group and 49.6% ± 14.5% vs 53.2% ± 12.8% in the metoprolol group). No adverse event was experienced. Metoprolol, a Β-1 selective blocker, can be used safely at the maximum dose in CAD patients with COPD.

Key words

Β-Blocker Coronary artery disease Chronic obstructive pulmonary disease 

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Copyright information

© Springer-Verlag Tokyo 2003

Authors and Affiliations

  • Ahmet Çamsarı
    • 1
  • Serpil Arıkan
    • 2
  • Candan Avan
    • 3
  • Deniz Kaya
    • 3
  • Hasan Pekdemir
    • 1
  • Dilek ÇiÇek
    • 1
  • Ahmet Kıykım
    • 4
  • Kerem Sezer
    • 4
  • Necdet AkkuŞ
    • 1
  • Mehmet Alkan
    • 3
  • Sinan Aydogˇdu
    • 3
  1. 1.Department of Cardiology, Faculty of MedicineUniversity of MersinMersinTurkey
  2. 2.Department of Respiratory DiseaseAnkara Numune Education and Research HospitalAnkaraTurkey
  3. 3.Department of CardiologyAnkara Numune Education and Research HospitalAnkaraTurkey
  4. 4.Department of Internal Medicine, Faculty of MedicineMersin UniversityMersinTurkey

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