Journal of Comparative Physiology B

, Volume 181, Issue 5, pp 667–680

Physiology of aging among healthy, older bottlenose dolphins (Tursiops truncatus): comparisons with aging humans

  • Stephanie Venn-Watson
  • Cynthia R. Smith
  • Forrest Gomez
  • Eric D. Jensen
Original Paper

DOI: 10.1007/s00360-011-0549-3

Cite this article as:
Venn-Watson, S., Smith, C.R., Gomez, F. et al. J Comp Physiol B (2011) 181: 667. doi:10.1007/s00360-011-0549-3

Abstract

Changes in hematological and serum chemistry values have been identified among older compared to younger humans. We hypothesized that healthy bottlenose dolphins (Tursiops truncatus) 30 years and older may demonstrate similar clinicopathological changes with increasing age. Retrospective hematological and serum chemistry data generated from routine, fasted blood samples collected over 10 to 20 years among six healthy dolphins that lived at least 40 years were analyzed to (1) assess linear trends in blood variable values with increasing age, (2) compare mean blood values by older age categories (30–35 years, 36–40 years, and >40 years), and (3) compare the prevalence of clinically high or low blood values by older age categories. Absolute lymphocytes, serum globulins, and mean platelet volume increased linearly with increasing old age. Mean white blood cells, neutrophils, serum globulins, erythrocyte sedimentation rates, serum cholesterol, and serum triglycerides; and the prevalence of neutrophilic leukocytosis, hyperglobulinemia, and hypercholesterolemia, were more likely to be higher as geriatric dolphins got older. A linear decrease in serum albumin with increasing age was present for five of six animals. Serum creatinine decreased among dolphins older than 40 years compared to when they were 30–40 years old. Our study demonstrates that older dolphins have changes in hematological and serum chemistry values similar to those found in older humans. As such, bottlenose dolphins may serve as a useful comparative model for aging in humans. Further studies are needed to assess whether these changes are associated with negative health outcomes and whether targeted therapeutics can help improve quality of life among aging dolphins.

Keywords

Aging Chronic inflammation Dolphin Hypercholesterolemia Hyperglobulinemia 

Abbreviations

WBC

White blood cell

HCT

Hematocrit

MCV

Mean corpuscular volume

MCH

Mean corpuscular hemoglobin

MCHC

Mean corpuscular hemoglobin concentration

BUN

Blood urea nitrogen

CO2

Carbon dioxide

ALP

Alkaline phosphatase

LDH

Lactate dehydrogenase

AST

Aspartate aminotransferase

ALT

Alanine aminotransferase

GGT

Gamma-glutamyl transpeptidase

CK

Creatine kinase

ESR

Erythrocyte sedimentation rate

eGFR

Estimated glomerular filtration rate

Copyright information

© Springer-Verlag (outside the USA) 2011

Authors and Affiliations

  • Stephanie Venn-Watson
    • 1
  • Cynthia R. Smith
    • 1
  • Forrest Gomez
    • 1
  • Eric D. Jensen
    • 2
  1. 1.National Marine Mammal FoundationSan DiegoUSA
  2. 2.Navy Marine Mammal Program, Biosciences DivisionSpace and Naval Warfare Systems Center PacificSan DiegoUSA

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