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Journal of Comparative Physiology A

, Volume 199, Issue 9, pp 785–797 | Cite as

Swim pacemaker response to bath applied neurotransmitters in the cubozoan Tripedalia cystophora

  • Jan BieleckiEmail author
  • Gösta Nachman
  • Anders Garm
Original Paper

Abstract

The four rhopalia of cubomedusae are integrated parts of the central nervous system carrying their many eyes and thought to be the centres of visual information processing. Rhopalial pacemakers control locomotion through a complex neural signal transmitted to the ring nerve and the signal frequency is modulated by the visual input. Since electrical synapses have never been found in the cubozoan nervous system all signals are thought to be transmitted across chemical synapses, and so far information about the neurotransmitters involved are based on immunocytochemical or behavioural data. Here we present the first direct physiological evidence for the types of neurotransmitters involved in sensory information processing in the rhopalial nervous system. FMRFamide, serotonin and dopamine are shown to have inhibitory effect on the pacemaker frequency. There are some indications that the fast acting acetylcholine and glycine have an initial effect and then rapidly desensitise. Other tested neuroactive compounds (GABA, glutamate, and taurine) could not be shown to have a significant effect.

Keywords

Neuromodulation Pacemaker FMRFamide Serotonin Dopamine 

Notes

Acknowledgments

The manuscript was significantly enhanced by thoughtful comments from two anonymous reviewers. JB acknowledges the Lundbeck Foundation Grant No. R103-A9339 and AG the Villum Foundation Grant No. VKR022166.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Marine Biological SectionUniversity of CopenhagenCopenhagenDenmark
  2. 2.Section of Ecology and EvolutionUniversity of CopenhagenCopenhagenDenmark

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