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Journal of Comparative Physiology A

, Volume 195, Issue 10, pp 961–969 | Cite as

Behaviorally measured audiograms and gap detection thresholds in CBA/CaJ mice

  • Kelly E. Radziwon
  • Kristie M. June
  • Daniel J. Stolzberg
  • Matthew A. Xu-Friedman
  • Richard J. Salvi
  • Micheal L. DentEmail author
Original Paper

Abstract

Tone detection and temporal gap detection thresholds were determined in CBA/CaJ mice using a Go/No-go procedure and the psychophysical method of constant stimuli. In the first experiment, audiograms were constructed for five CBA/CaJ mice. Thresholds were obtained for eight pure tones ranging in frequency from 1 to 42 kHz. Audiograms showed peak sensitivity between 8 and 24 kHz, with higher thresholds at lower and higher frequencies. In the second experiment, thresholds for gap detection in broadband and narrowband noise bursts were measured at several sensation levels. For broadband noise, gap thresholds were between 1 and 2 ms, except at very low sensation levels, where thresholds increased significantly. Gap thresholds also increased significantly for low pass-filtered noise bursts with a cutoff frequency below 18 kHz. Our experiments revised absolute auditory thresholds in the CBA/CaJ mouse strain and demonstrated excellent gap detection ability in the mouse. These results add to the baseline behavioral data from normal-hearing mice which have become increasingly important for assessing auditory abilities in genetically altered mice.

Keywords

Mouse Mus musculus Audiogram Gap detection Psychophysics 

Abbreviations

ABR

Auditory brainstem response

MOCS

Method of constant stimuli

NMRI

Naval Medical Research Institute

SPL

Sound pressure level

SL

Sensation level

Notes

Acknowledgments

We would like to thank the many UB undergraduate research assistants, Jarrod Cone, and Kelly Beedon for their assistance. Thanks to John Cone for assistance with the artwork creation and to Dr. Amanda Lauer, Dr. Cynthia Prosen, and Dr. Georg Klump for advice. This work was funded by a University at Buffalo Interdisciplinary Research Fund grant to MAX, RJS, and MLD, and NIH Grant DC009483 to MLD. The experiments complied with the “Principles of Animal Care”, publication from the National Institutes of Health, and were approved by the University at Buffalo IACUC.

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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Kelly E. Radziwon
    • 1
  • Kristie M. June
    • 1
  • Daniel J. Stolzberg
    • 2
  • Matthew A. Xu-Friedman
    • 3
    • 4
  • Richard J. Salvi
    • 2
    • 4
  • Micheal L. Dent
    • 1
    • 4
    Email author
  1. 1.Department of PsychologyUniversity at Buffalo, The State University of New YorkBuffaloUSA
  2. 2.Department of Communication Disorders and SciencesUniversity at Buffalo, The State University of New YorkBuffaloUSA
  3. 3.Department of Biological SciencesUniversity at Buffalo, The State University of New YorkBuffaloUSA
  4. 4.Center for Hearing and DeafnessUniversity at Buffalo, The State University of New YorkBuffaloUSA

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