Behaviorally measured audiograms and gap detection thresholds in CBA/CaJ mice
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Tone detection and temporal gap detection thresholds were determined in CBA/CaJ mice using a Go/No-go procedure and the psychophysical method of constant stimuli. In the first experiment, audiograms were constructed for five CBA/CaJ mice. Thresholds were obtained for eight pure tones ranging in frequency from 1 to 42 kHz. Audiograms showed peak sensitivity between 8 and 24 kHz, with higher thresholds at lower and higher frequencies. In the second experiment, thresholds for gap detection in broadband and narrowband noise bursts were measured at several sensation levels. For broadband noise, gap thresholds were between 1 and 2 ms, except at very low sensation levels, where thresholds increased significantly. Gap thresholds also increased significantly for low pass-filtered noise bursts with a cutoff frequency below 18 kHz. Our experiments revised absolute auditory thresholds in the CBA/CaJ mouse strain and demonstrated excellent gap detection ability in the mouse. These results add to the baseline behavioral data from normal-hearing mice which have become increasingly important for assessing auditory abilities in genetically altered mice.
KeywordsMouse Mus musculus Audiogram Gap detection Psychophysics
Auditory brainstem response
Method of constant stimuli
Naval Medical Research Institute
Sound pressure level
We would like to thank the many UB undergraduate research assistants, Jarrod Cone, and Kelly Beedon for their assistance. Thanks to John Cone for assistance with the artwork creation and to Dr. Amanda Lauer, Dr. Cynthia Prosen, and Dr. Georg Klump for advice. This work was funded by a University at Buffalo Interdisciplinary Research Fund grant to MAX, RJS, and MLD, and NIH Grant DC009483 to MLD. The experiments complied with the “Principles of Animal Care”, publication from the National Institutes of Health, and were approved by the University at Buffalo IACUC.
- Birch LM, Warfield D, Ruben RJ, Mikaelian DO (1968) Behavioral measurements of pure tone thresholds in normal CBA-J mice. J Auditory Res 8:459–468Google Scholar
- Buus S, Florentine M (1985) Gap detection in normal and impaired listeners: The effect of level and frequency. In: Michelsen A (ed) Time resolution in auditory systems. Springer, London, pp 159–179Google Scholar
- Heffner HE, Heffner RS (2001) Behavioral assessment of hearing in mice. In: Willott JF (ed) Handbook of mouse auditory research. CRC Press, Boca Raton, pp 19–29Google Scholar