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Journal of Comparative Physiology A

, Volume 194, Issue 5, pp 429–439 | Cite as

Absence of functional short-wavelength sensitive cone pigments in hamsters (Mesocricetus)

  • Gary A. Williams
  • Gerald H. Jacobs
Original Paper

Abstract

Studies of Syrian golden hamsters (Mesocricetus auratus) have yielded contradictory evidence as to whether the retina of this species supports a population of cones containing short-wavelength sensitive pigments. We undertook a re-examination of this issue by (a) measuring lens transmission, (b) determining complete spectral sensitivity functions using electroretinogram (ERG) flicker photometry, (c) employing a sensitive chromatic-adaptation paradigm in conjunction with ERG measurements to conduct a specific search for the presence of a short-wavelength sensitive mechanism, and (d) assaying for the presence of retinal mRNA using real-time, reverse transcription polymerase chain reactions (RT-PCR). Parallel measurements were made on Turkish hamster (Mesocricetus brandtii) and control measurements were derived from recordings made on a rodent whose retina is known to contain a population of short-wavelength sensitive cones (the rat, Rattus norvegicus). Although UV opsin transcripts can be detected in the retina of the Syrian hamster, the electrophysiological measurements imply that these are not translated. Syrian hamsters thus lack a functional short-wavelength sensitive pigment, and that seems also true for the Turkish hamster. Members of this genus belong to a disparate group of mammals that have lost function of their short-wavelength sensitive cone pigments through ancestral opsin gene mutations.

Keywords

Hamsters Mesocricetus Short-wavelength sensitive cone pigments Opsin gene mutations Electroretinogram 

Notes

Acknowledgments

We thank Kris Krogh and Jack Calderone for help with some of the measurements. All animal care and experimental procedures were in accordance with institutional care and use guidelines and with the Principles of animal care, publication No. 86–23 of the National Institutes of Health. This research was facilitated by a grant from the National Eye Institute (EY002052)

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  1. 1.Neuroscience Research Institute and Department of PsychologyUniversity of CaliforniaSanta BarbaraUSA

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