Zusammenfassung
Menschen nehmen Informationen aus ihrem Umfeld zum größten Teil über das visuelle System auf. Dabei werden Signale von den Photorezeptoren der Retina über Bipolar- und Ganglienzellen auf spezifische neuronale Subpopulationen im Corpus geniculatum laterale projiziert und von dort aus in zugeordnete Schichten des primären visuellen Kortex weitergeleitet. Die wichtigsten anatomischen und funktionellen Merkmale des visuellen Systems werden beleuchtet. Dazu fand eine selektive Literaturrecherche in den Datenbanken PubMed (auch in der Europe PubMed Central), Psychline, Google Scholar, Cochrane Library und Web of Science statt, und es wurden zusätzliche Angaben einschlägiger Werke bzw. Websites auf den Gebieten (Neuro‑)Anatomie, (Neuro‑)Physiologie und (Neuro‑)Otologie u. a. mit den Suchbegriffen Sehbahn, „visual system“, „visual pathway“, „receptors“, „spatial cognition“, „visual cognition“ einbezogen.
Abstract
Humans receive information from their environment mainly via the visual system. Signals from the photoreceptors of the retina via bipolar and ganglion cells are projected onto specific neuronal subpopulations in the lateral geniculate body and from there are forwarded to appropriate layers of the primary visual cortex. The most important anatomical and functional features of the visual system are explained. For this purpose, a selective literature search was carried out in the databases PubMed (also in Europe PubMed Central), Psychline, Google Scholar, Cochrane Library and Web of Science as well as additional information in relevant books or websites in the fields of (neuro)anatomy, (neuro)physiology, (neuro)ophthalmology and (neuro)otology, among others with the search terms Sehbahn, visual system, visual pathway, receptors, spatial cognition and visual cognition.
Literatur
Allison T, McCarthy G, Nobre A et al (1994) Human extrastriate visual cortex and the perception of faces, words, numbers, and colors. Cereb Cortex 4:544–554. https://doi.org/10.1093/cercor/4.5.544
Anderson DR, William FH (1969) The projection of the macula in the lateral geniculate nucleus of man. Arch Ophthalmol 82:506–530
Bell RA, Thompson HS (1978) Relative afferent pupillary defect in optic tract hemianopias. Am J Ophthalmol 85:538–540. https://doi.org/10.1016/S0002-9394(14)75251-1
Berson DM (2003) Strange vision: ganglion cells as circadian photoreceptors. Trends Neurosci 26:314–320
Berson DM, Dunn FA, Takao M (2002) Phototransduction by retinal ganglion cells that set the circadian clock. Science 295:1070–1073
Biran I, Coslett HB (2003) Visual agnosia. Curr Neurol Neurosci Rep 3:508–512. https://doi.org/10.1007/s11910-003-0055-4
Connolly M, Van Essen D (1984) The representation of the visual field in parvicellular and magnocellular layers of the lateral geniculate nucleus in the macaque monkey. J Comp Neurol 226:544–564
DeYoe EA, Carman GJ, Bandettini P et al (1996) Mapping striate and extrastriate visual areas in human cerebral cortex. Proc Natl Acad Sci USA 93:2382–2386
Daniels DL, Haughton V, Williams A et al (1980) Computed tomography of the optic chiasm. Radiology 137:123–127. https://doi.org/10.1148/radiology.137.1.7422833
Ebeling U, Reulen HJ (1988) Neurosurgical topography of the optic radiation in the temporal lobe. Acta Neurochir 92:29–36
van Essen DC, Maunsell JH (1980) Two-dimensional maps of the cerebral cortex. J Comp Neurol 191:255–281
Euler T, Haverkamp S, Schubert T, Baden T (2014) Retinal bipolar cells: elementary building blocks of vision. Nat Rev Neurosci 15:507–519
Glaser JS (1967) The nasal visual field. Arch Ophthalmol 77:358–360
Hattar S, Liao HW, Takao M et al (2002) Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivity. Science 295:1065–1070
Horton JC, Hoyt WF (1991) The representation of the visual field in human striate cortex. A revision of the classic Holmes map. Arch Ophthalmol 109:816–824
Hoyt W (1975) Geniculate hemianopias: incongruous visual defects from partial involvement of the lateral geniculate nucleus. Proc Aust Assoc Neurol 12:7–16
Hubel DH, Wiesel TN (1977) Ferrier lecture—functional architecture of macaque monkey visual cortex. Proc R Soc Lond B Biol Sci 198:1–59. https://doi.org/10.1098/rspb.1977.0085
Jacobson M, Hirose G (1978) Origin of the retina from both sides of the embryonic brain: a contribution to the problem of crossing at the optic chiasma. Science 202:637–639. https://doi.org/10.1126/science.705349
Jansonius NM, Nevalainen J, Selig B et al (2009) A mathematical description of nerve fiber bundle trajectories and their variability in the human retina. Vision Res 49:2157–2163
Jansonius NM, Schiefer J, Nevalainen J et al (2012) A mathematical model for describing the retinal nerve fiber bundle trajectories in the human eye: average course, variability, and influence of refraction, optic disc size and optic disc position. Exp Eye Res 105:70–78. https://doi.org/10.1016/j.exer.2012.10.008
Kaas JH, Guillery RW, Allman JM (1972) Some principles of organization in the dorsal lateral geniculate nucleus. Brain Behav Evol 6:253–299
Kolb H, Linberg KA, Fisher SK (1992) Neurons of the human retina: a Golgi study. J Comp Neurol 318:147–187. https://doi.org/10.1002/cne.903180204
Kupfer C (1962) The projection of the macula in the lateral geniculate nucleus of man. Am J Ophthalmol 54:597–609. https://doi.org/10.1016/0002-9394(62)92190-6
Leventhal AG, Ault SJ, Vitek DJ (1988) The nasotemporal division in primate retina: the neural bases of macular sparing and splitting. Science 240:66–67
Livingstone M, Hubel D (1988) Segregation of form, color, movement, and depth: anatomy, physiology, and perception. Science 240:740–749. https://doi.org/10.1126/science.3283936
Lorenz B, Strohmayr E, Zahn S et al (2012) Chromatic pupillometry dissects function of the three different light-sensitive retinal cell populations in RPE65 deficiency. Invest Ophthalmol Vis Sci 53:5641–5652. https://doi.org/10.1167/iovs.12-9974
Malpeli JG, Barker FH (1975) The representation of the visual field in the lateral geniculate nucleus of macaca mulatta. J Comp Neurol 161:569–594
Maunsell JHR (1995) The brain’s visual world: representation of visual targets in cerebral cortex. Science 270:764–769
Minckler DS (1980) The organization of nerve fiber bundles in the primate optic nerve head. Arch Ophthalmol 98:1630–1636. https://doi.org/10.1001/archopht.1980.01020040482019
Minckler DS (1986) Correlations between anatomic features and axonal transport in primate optic nerve head. Trans Am Ophthalmol Soc 84:429–452
Newman SA, Miller NR (1983) Optic tract syndrome. Neuro-ophthalmologic considerations. Arch Ophthalmol 101:1241–1250
Nieuwenhuys R, Voogd J, van Huijzen C (2007) The human central nervous system. A synopsis and atlas, 4. Aufl. Springer, Berlin
Ogden TE (1983) Nerve fiber layer of the owl monkey retina: retinotopic organization. Invest Ophthalmol Vis Sci 24:265–269
Osterberg G (1935) Topography of the layer of the rods and cones in the human retima. Acta Ophthalmol 13:1–102
Parker AJ (2007) Binocular depth perception and the cerebral cortex. Nat Rev Neurosci 8:379–391. https://doi.org/10.1038/nrn2131
Rucker CW (1958) The concept of a semidecussation of the optic nerves. Arch Ophthalmol 59:159–171
Sanes J, Masland R (2016) The types of retinal ganglion cells: current status and implications for neuronal classification. Annu Rev Neurosci 8:221–246. https://doi.org/10.1146/annurev-neuro-071714-034120
Savino PJ, Paris M, Schatz NJ et al (1978) Optic tract syndrome: a review of 21 patients. Arch Ophthalmol 96:656–663. https://doi.org/10.1001/archopht.1978.03910050352011
Stephan FK, Zucker I (1972) Circadian rhythms in drinking behavior and locomotor activity of rats are eliminated by hypothalamic lesions. Proc Natl Acad Sci USA 69:1583–1586. https://doi.org/10.1073/pnas.69.6.1583
Traquair HM (1938) An introduction to clinical perimetry. Kimpton, London
Trepel M (1995) Neuroanatomie. Struktur und Funktion. Urban & Schwarzenberg, München
Ungerleider LG, Haxby JV (1994) ‘What’ and ‘where’ in the human brain. Curr Opin Neurobiol 4:157–165. https://doi.org/10.1016/0959-4388(94)90066-3
Ungewiss J, Milenkovic I, Breuninger T, Ebenhoch R, Schiefer U (2020) Vergleich von Sehbahn und Hörbahn. Ophthalmologe
Van Essen DC, Anderson CH, Felleman DJ (1992) Information processing in the primate visual system: an integrated systems perspective. Science 255:419–423
Warren EJ, Allen CN, Brown RL, Robinson DW (2003) Intrinsic light responses of retinal ganglion cells projecting to the circadian system. Eur J Neurosci 17:1727–1735. https://doi.org/10.1046/j.1460-9568.2003.02594.x
Danksagung
Die Autoren danken Frau Prof. Dr. med. Annette Limberger, Frau Isabel Schöllhorn und Frau Sandra Wagner für die Unterstützung bei der Erarbeitung eines ersten Konzepts zur Gegenüberstellung der Seh- und Hörbahn sowie Frau Irena Stingl für die Unterstützung bei der Erarbeitung der Grafiken.
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U. Schiefer ist als Consultant für die Fa. Haag-Streit, Köniz/CH, tätig. J. Ungewiss, T. Breuninger, I. Milenkovic und R. Ebenhoch geben an, dass kein Interessenkonflikt besteht.
Für diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.
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Ungewiss, J., Breuninger, T., Milenkovic, I. et al. Aufbau und Funktion der Sehbahn. Ophthalmologe 117, 1062–1067 (2020). https://doi.org/10.1007/s00347-020-01069-7
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DOI: https://doi.org/10.1007/s00347-020-01069-7