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Der Ophthalmologe

, Volume 104, Issue 5, pp 431–443 | Cite as

Primäres Offenwinkelglaukom und Allgemeinerkrankungen

  • M. PacheEmail author
CME Weiterbildung • Zertifizierte Fortbildung

Zusammenfassung

Der genaue Pathomechanismus des primären Offenwinkelglaukoms (POWG) ist bis heute nicht vollständig entschlüsselt. Neben dem klar identifizierten Risikofaktor „Augeninnendruck“ gibt es zahlreiche Hinweise auf die Beteiligung von systemischen Faktoren bzw. Erkrankungen an der Entstehung des Schadens. Hierzu zählen kardiovaskuläre, endokrinologische und neurodegenerative Erkrankungen ebenso wie gewisse Schlafstörungen. Es ist allerdings nicht immer klar, ob es sich um eine Koinzidenz oder einen tatsächlichen Zusammenhang zwischen der jeweiligen Allgemeinerkrankung und dem POWG handelt. Viele diesbezüglich zur Verfügung stehenden Publikationen werden zudem unserem heutigem Bewertungsmaßstab nicht gerecht. Oft liegen lediglich Einzelfälle, kleine Fallserien oder retrospektive Datenanalysen vor, und Negativstudien sind vermutlich häufig gar nicht veröffentlicht worden. Tatsächlich aber gibt es, v. a. auf dem Gebiet der vaskulären Komponente des Glaukoms, zahlreiche Ergebnisse, die von mehreren unabhängigen Arbeitsgruppen bestätigt wurden.

Schlüsselwörter

Glaukom Allgemeinerkrankungen Hypertonie Hypotonie Diabetes mellitus 

Primary open-angle glaucoma and systemic diseases

Abstract

The exact pathomechanism of primary open-angle glaucoma (POAG) is still not completely understood. Besides elevated intraocular pressure, which has been identified as a major risk factor, there is mounting evidence for the involvement of systemic factors in the development of glaucomatous damage. Systemic peculiarities described in POAG include cardiovascular, endocrine, neurodegenerative, and sleep alterations. However, some of the studies available on systemic findings in glaucoma patients are contradictory, making further research necessary to identify the exact role of such disturbances in the pathogenesis of the damage. Another difficulty is that many studies are limited by their small sample size, their retrospective nature, and potential selection bias, thus making data interpretation more difficult. Moreover, it is not always clear whether we are dealing with coincidence or a true association between glaucoma and a particular systemic disease. Nevertheless, there is ample evidence for the involvement of vascular factors such as vascular dysregulation and blood pressure in the pathogenesis of POAG.

Keywords

Glaucoma Systemic disease Hypertension Hypotension Diabetes mellitus 

Notes

Interessenkonflikt

Es besteht kein Interessenkonflikt. Der korrespondierende Autor versichert, dass keine Verbindungen mit einer Firma, deren Produkt in dem Artikel genannt ist, oder einer Firma, die ein Konkurrenzprodukt vertreibt, bestehen. Die Präsentation des Themas ist unabhängig und die Darstellung der Inhalte produktneutral.

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Copyright information

© Springer Medizin Verlag 2007

Authors and Affiliations

  1. 1.UniversitätsaugenklinikUniversität FreiburgFreiburgDeutschland

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