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Vergleich des ILM-Peelings mit und ohne Einsatz von Indozyaningrün

Funktionelle Ergebnisse bei idiopathischem Makulaforamen nach Pars-plana-Vitrektomie

Comparison of ILM peeling with and without the use of indocyanine green

Functional results for idiopathic macular hole after pars plana vitrectom

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Zusammenfassung

Hintergrund

Bei idiopathischen Makulaforamina ist eine Pars-plana-Vitrektomie (PPV) mit Peeling der Membrana limitans interna (ILM) die Therapie der Wahl. Indozyaningrün (ICG) ist zur Anfärbung der ILM hilfreich, obwohl es dosisabhängig toxisch ist. Die Visusentwicklung nach ILM-Peeling mit und ohne Einsatz von ICG wurde verglichen.

Methode

Retrospektiv erfolgte die Auswertung der Daten von 61 Patienten, die sich wegen idiopathischer Makulaforamina einer PPV mit ILM-Peeling unterzogen hatten. Dabei waren 36 Augen mit und 25 Augen ohne den Einsatz von ICG operiert worden. Visusunterschiede zwischen beiden Gruppen prüften wir nach Umrechnung in logMAR durch den Mann-Whitney-U-Test auf Signifikanz.

Ergebnisse

Der präoperative logMAR der Gesamtgruppe betrug 0,71±0,30 (Visus 0,2), einen Monat nach der Operation 0,71±0,36 (0,2), nach 3 Monaten 0,57±0,26 (0,25), nach 6 Monaten 0,54±0,38 (0,3) und nach 12 Monaten 0,36±0,32 (0,4). Signifikante Unterschiede zwischen beiden Gruppen bestanden nicht.

Schlussfolgerung

Hinsichtlich der Visusentwicklung und Verschlussrate ließ sich kein signifikanter Unterschied zwischen den Patientengruppen, die mit und ohne Einsatz von ICG behandelt wurden, feststellen.

Abstract

Background

Pars plana vitrectomy with internal limiting membrane (ILM) peeling is the best known therapy for idiopathic macular holes. Indocyanine green (ICG) is useful for staining the ILM, although there is a dose related toxic effect on the inner retinal layers. We compared outcome results with and without the use of ICG.

Method

Data from 61 patients with idiopathic macular holes, who underwent macular hole surgery were analyzed retrospectively. ICG was used on 36 eyes while for 25 eyes it was not used. After calculating logMAR, differences in visual acuity between both groups were analyzed for significance using the Mann-Whitney-U-Test.

Results

The logMAR for the entire group was 0.71±0.30 (20/100) preoperatively, after 1 month 0.71±0.36 (20/100), after 3 months 0.57±0.26 (20/80), after 6 months 0.54±0.38 (20/66) and after 12 months 0.36±0.32 (20/50). There were no significant differences between groups.

Conclusion

There seem to be no significant differences in the development of visual acuity and the occlusion rate between patients treated with or without the use of ICG.

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Authors and Affiliations

  1. Klinik für Ophthalmologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Hegewischstraße 2, 24105, Kiel

    F. Rüfer, A. Frimpong-Boateng, A. Bunse & J. Roider

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  1. F. Rüfer
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  2. A. Frimpong-Boateng
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  3. A. Bunse
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Correspondence to F. Rüfer.

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Rüfer, F., Frimpong-Boateng, A., Bunse, A. et al. Vergleich des ILM-Peelings mit und ohne Einsatz von Indozyaningrün. Ophthalmologe 104, 54–59 (2007). https://doi.org/10.1007/s00347-006-1379-7

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