World Journal of Urology

, Volume 18, Issue 1, pp 19–25 | Cite as

Organ-specific acellular matrix for reconstruction of the urinary tract

  • Karl-Dietrich Sievert
  • Emil A. Tanagho

Abstract

In urology, replacement of organs or organ segments has proved problematic. Current techniques do not replicate complete organ function, and they cause well-known complications. With the acellular organ-specific matrix we have found a way to regenerate tissue components seen in the normal lower urinary tract. The time required for regeneration depends on the matrix size and function. The matrix is covered by urothelium migrating from the host, after which neovascularization occurs, followed by formation of smooth-muscle cells and nerves. In our studies, normal muscle lining and nerves providing functional tissue were demonstrable and no sign of antigenicity was evident, even after heterologous grafting. The regenerated rat bladder was evaluated by organ bath as well as by in vivo functional tests and demonstrated properties and functions similar to those of host tissue. Besides our obtaining encouraging results in the rat bladder, we also studied the organ-specific acellular matrix in other species (dog and rabbit) and other organ segments (ureter and urethra).

Key words Homograft Xenograft Acellular matrix Transplantation Graft survival Urodynamics Organ bath Growth factors Animal models 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • Karl-Dietrich Sievert
    • 1
  • Emil A. Tanagho
    • 1
  1. 1.Department of Urology, U-575, University of California School of Medicine, San Francisco, CA 94143-0738, USA Tel.: +1-415-4768844/4761611, Fax: +1-415-4763564/4768849US
  2. 2.Klinik und Poliklinik für Urologie, Westfälische Wilhelms-Universität, Münster, GermanyDE

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