Transurethral prostate surgery as a preventive method against progression of chronic kidney disease in patients with urodynamically proven bladder outlet obstruction

  • Dong Sup Lee
  • Hyung Wook Kim
  • Seung-ju LeeEmail author
Original Article



The present study was aimed to investigate (1) whether urodynamic factors are responsible for kidney damage in patients with bladder outlet obstruction (BOO) and (2) whether transurethral prostate surgery for BOO can alleviate the damage to the kidneys.


This prospective observational study involved men aged 50–80 years. Prostate size and urodynamic test were performed during screening period. Laboratory tests to measure the glomerular filtration rate, the urinary protein to creatinine ratio and dipstick urinalysis were performed before and 6 months after the transurethral prostate surgery.


Sixty-seven patients completed the laboratory study among a hundred enrolled patients with urodynamically proven BOO. Among the urodynamic parameters, only low bladder compliance (lower than 60 mL/cmH2O) was associated with clinically significant proteinuria (p < 0.001). Transurethral prostate surgery significantly improved proteinuria (p = 0.007), especially in patients with low bladder compliance (p = 0.004), and subsequently decreased the risk grade of CKD progression (p < 0.001).


Low bladder compliance in patients with BOO may be a risk factor for kidney damage. Transurethral prostate surgery to relieve BOO could be a preventive method against CKD progression in patients with low bladder compliance.


Benign prostate hyperplasia Urinary bladder Compliance Proteinuria Chronic kidney disease 



The authors wish to acknowledge the financial support from the Catholic Medical Center Research Foundation in the program year of 2016. We are particularly grateful to Inae Park (Department of Urology, St. Vincent’s Hospital) for assisting with data processing.

Author contributions

DSL: protocol development, manuscript writing, data collection, data analysis; HWK: manuscript editing, data analysis; SJL: protocol development, manuscript editing.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The institutional review board approved the observational study design and access to the patients’ medical records (approval number: VC13OISI0222, date of approval: February 26th, 2014). Additionally, this project was registered at (Register no: L201401N1). This study was performed in accordance with the Declaration of Helsinki. This article does not contain any studies with animals performed by any of the authors.

Informed consent

Informed consent was obtained from all individual participants in the study.

Supplementary material

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Supplementary file1 (JPG 819 kb)
345_2019_3041_MOESM2_ESM.doc (45 kb)
Supplementary file2 (DOC 45 kb)


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Urology, St. Vincent’s Hospital, College of MedicineThe Catholic University of KoreaSuwonKorea
  2. 2.Department of Nephrology, St. Vincent’s HospitalThe Catholic University of KoreaSuwonKorea

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