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Prospective analysis of artificial urinary sphincter AMS 800 implantation after buccal mucosa graft urethroplasty

  • Valentin Maurer
  • Phillip Marks
  • Roland Dahlem
  • Clemens Rosenbaum
  • Christian P. Meyer
  • Silke Riechardt
  • Margit FischEmail author
  • Tim Ludwig
Topic Paper
  • 35 Downloads

Abstract

Objectives

To analyze functional outcomes and complication rates of artificial urinary sphincter (AUS) implantation in patients who had undergone buccal mucosa graft urethroplasty (BMGU) beforehand.

Patients and methods

This prospectively maintained single-center database comprises data from 236 patients from 2009 to 2015 who underwent AUS implantation. A total of 17 patients after BMGU were available for analysis. Primary endpoints consisted of continence and complication rates. Continence was defined as no use of safety pads, social continence as < 2 pads per day. Stricture recurrence was defined as a decrease in uroflowmetry, a maximum flow rate < 10 ml/s or residual urine volume (> 100 ml). Kaplan–Meier analysis determined explantation-free survival.

Results

Median follow-up was 24 months (interquartile range [IQR] 6–31 months). Indication for AUS implantation was severe urinary incontinence with a history of radical prostatectomy (RRP) in 8 (47.1%), trauma in 1 (5.9%) and TUR-P in 8 (47.1%) patients. Pelvic irradiation was reported in 13 (76.5%) cases. The median length of buccal mucosa graft for urethroplasty was 4 cm (3–5 cm). A double cuff was implanted in 14 patients (82.4%), 3 patients received a single cuff. Complete and social continence was achieved in 76.5% and 100% of the patients, respectively. There was no significant difference in complications and explantation-free survival (log-rank, p = 0.191) between patients who had undergone BMGU before AUS compared to patients with no history of BMGU.

Conclusions

According to the prospective follow-up data in a homogenous cohort, AUS implantation seems to be a viable, safe and effective therapeutic strategy for incontinence treatment despite previous BMGU.

Keywords

AMS 800 Artificial urinary sphincter Buccal mucosa graft urethroplasty Reconstructive urology Postprostatectomy stress urinary incontinence 

Notes

Author contributions

VM and PM: Data Collection and Analysis, Project Development, Manuscript Writing. RD: Data Collection, Manuscript Editing. CR and CPM: Manuscript Editing. SR and MR: Manuscript Editing. TAL: Data Collection and Analysis, Project Development, Manuscript Editing.

Compliance with ethical standards

Conflict of interest

Margit Fisch and Roland Dahlem has served as consultant for Boston Scientific. All other authors declare they have no conflict of interest.

Ethical approval

All procedures performed in our studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of UrologyUniversity Hospital Hamburg-EppendorfHamburgGermany

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