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World Journal of Urology

, Volume 37, Issue 9, pp 1899–1905 | Cite as

Comparison of biopsy devices in upper tract urothelial carcinoma

  • Alberto BredaEmail author
  • Angelo Territo
  • Francesco Sanguedolce
  • Giuseppe Basile
  • Jose D. Subiela
  • Helena Vila Reyes
  • Olga Mayordomo Ferrer
  • Jose M. Gaya
  • Joan Palou
Original Article

Abstract

Introduction

A correct characterization of upper tract urothelial carcinoma (UTUC) lesions is fundamental to appropriately select patients suitable for endoscopic management. We analyzed the diagnostic yield of three different biopsy tools for the histology evaluation of the UTUC. Furthermore, the concordance between biopsy grading and final UTUC pathology results at specimen (i.e., after ureterectomy or radical nephroureterectomy—RNU) was evaluated.

Materials and methods

Three different devices were evaluated: 3F biopsy forceps, 6F BIGopsy® Backloading biopsy forceps and the 2.2F Nitinol Basket. Data were collected between January 2015 and October 2017 and retrospectively analyzed. Univariate and multivariate logistic regression analyses were performed to identify the variables related to diagnosis.

Results

A total of 302 biopsies were taken: lesions could be characterized in 236 (78.2%) specimens by the pathologist. Positive biopsies for UTUC were found in 140 specimens. In 66 biopsies (21.8%), the quality of the tissue sampled was inadequate for a histological characterization; of these, 55 (83.3%) were taken using 3F forceps and 11 (16.7%) using BIGopsy forceps. No inadequate specimen arose using the 2.2F Nitinol Basket. Among 28 patients who underwent distal ureterectomy or RNU, the tumor was upgraded to high grade in 9 (32%), while in 19 (68%) the grading was confirmed.

Conclusion

In comparison to 3F forceps, the BIGopsy forceps showed to be more accurate in obtaining sufficient specimen for pathologic examination. In papillary lesions, the 2.2F Nitinol basket achieves a final histology characterization in 100% of the cases. For tumor < 2 cm, there is a high concordance between URS biopsy grade and final pathology (distal ureterectomy or RNU).

Keywords

Biopsy Flexible ureteroscopy Nephro-sparing surgery Upper tract urothelial carcinoma 

Abbreviations

CIS

Carcinoma in situ

CT

Computed tomography

EAU

European Urology Association

f-URS

Flexible ureteroscopy

sr-URS

Semirigid ureteroscopy

NSS

Nephro-sparing surgery

RNU

Radical nephroureterectomy

URS

Ureteroscopy

UTUC

Upper tract urothelial carcinoma

Notes

Author contributions

AB, AT protocol/project development. AT, FS, GB, JDS, HVR, OMF, JMG, JP data collection or management. AT, FS, GB, JDS data analysis.

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.

Informed consent

The research involved human participants obtaining informed consent.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Alberto Breda
    • 1
    Email author
  • Angelo Territo
    • 1
  • Francesco Sanguedolce
    • 1
  • Giuseppe Basile
    • 1
  • Jose D. Subiela
    • 1
  • Helena Vila Reyes
    • 1
  • Olga Mayordomo Ferrer
    • 1
  • Jose M. Gaya
    • 1
  • Joan Palou
    • 1
  1. 1.Department of UrologyFundació Puigvert, Autonomous University of BarcelonaBarcelonaSpain

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