World Journal of Urology

, Volume 37, Issue 1, pp 51–60 | Cite as

ICUD-SIU International Consultation on Bladder Cancer 2017: management of non-muscle invasive bladder cancer

  • Leonardo L. Monteiro
  • J. Alfred Witjes
  • Piyush K. Agarwal
  • Christopher B. Anderson
  • Trinity J. Bivalacqua
  • Bernard H. Bochner
  • Joost L. Boormans
  • Sam S. Chang
  • Jose L. Domínguez-Escrig
  • James M. McKiernan
  • Colin Dinney
  • Guilherme Godoy
  • Girish S. Kulkarni
  • Paramananthan Mariappan
  • Michael A. O’Donnell
  • Cyrill A. Rentsch
  • Jay B. Shah
  • Eduardo Solsona
  • Robert S. Svatek
  • Antoine G. van der Heijden
  • F. Johannes P. van Valenberg
  • Wassim KassoufEmail author
Invited Review



To provide a summary of the Third International Consultation on Bladder Cancer recommendations for the management of non-muscle invasive bladder cancer (NMIBC).


A detailed review of the literature was performed focusing on original articles for the management of NMIBC. An international committee assessed and graded the articles based on the Oxford Centre for Evidence-based Medicine system. The entire spectrum of NMIBC was covered such as prognostic factors of recurrence and progression, risk stratification, staging, management of positive urine cytology with negative white light cystoscopy, indications of bladder and prostatic urethral biopsies, management of Ta low grade (LG) and high risk tumors (Ta high grade [HG], T1, carcinoma in situ [CIS]), impact of BCG strain and host on outcomes, management of complications of intravesical therapy, role of alternative therapies, indications for early cystectomy, surveillance strategies, and new treatments. The working group provides several recommendations on the management of NMIBC.


Recommendations were summarized with regard to staging; management of primary and recurrent LG Ta and high risk disease, positive urine cytology with negative white light cystoscopy and prostatic urethral involvement; indications for timely cystectomy; and surveillance strategies.


NMIBC remains a common and challenging malignancy to manage. Accurate staging, grading, and risk stratification are critical determinants of the management and outcomes of these patients. Current tools for risk stratification are limited but informative, and should be used in clinical practice when determining diagnosis, surveillance, and treatment of NMIBC.


Bladder cancer Non-muscle invasive bladder cancer Transurethral resection of bladder tumor Staging Diagnosis Treatment Surveillance Bacillus Calmette–Guerin Guidelines ICUD 


Author contributions

LLM: manuscript writing/editing, project development. JAW: manuscript writing/editing. PKA: manuscript writing. CBA: manuscript writing. TJB: manuscript writing. BHB: manuscript writing. JLB: manuscript writing. SSC: manuscript writing. JLD: manuscript writing. JMM: manuscript writing. CD: manuscript writing. GG: manuscript writing. GSK: manuscript writing. PM: manuscript writing. MAO: manuscript writing. CAR: manuscript writing. JBS: manuscript writing. ES: manuscript writing. RSS: manuscript writing. AGH: manuscript writing. FJPV: manuscript writing. WK: manuscript writing/editing, project development

Compliance with ethical standards

Conflict of interest

Author JA Witjes has relationship with Sanofi Pasteur, MEL Amsterdam (Synergo), Cepheid, Nucleix, BMS, Taris, BioCancel and Spectrum. Author SS Chang has relationship with Mdx Health, BioCancel, Bristol Myers Squibb, and Altor. Author GS Kulkarni has received research funds from Biosyent Canada. Author MA O’Donnell has relationship with Abbot Molecular, Roche, Photocure, Urogen, Medical Enterprises, Viventia, Spectrum, Fidia Pharmaceuticals, Vaxiion Pharmaceuticals, and Therlasae. The other authors declare that they have no conflict of interest.

Research involving human participants and/or animals

For this type of study formal consent is not required. This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

For this type of study formal consent is not required.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Leonardo L. Monteiro
    • 1
  • J. Alfred Witjes
    • 2
  • Piyush K. Agarwal
    • 3
  • Christopher B. Anderson
    • 4
  • Trinity J. Bivalacqua
    • 5
  • Bernard H. Bochner
    • 6
  • Joost L. Boormans
    • 7
  • Sam S. Chang
    • 8
  • Jose L. Domínguez-Escrig
    • 9
  • James M. McKiernan
    • 4
  • Colin Dinney
    • 10
  • Guilherme Godoy
    • 11
  • Girish S. Kulkarni
    • 12
  • Paramananthan Mariappan
    • 13
  • Michael A. O’Donnell
    • 14
  • Cyrill A. Rentsch
    • 15
  • Jay B. Shah
    • 16
  • Eduardo Solsona
    • 9
  • Robert S. Svatek
    • 17
  • Antoine G. van der Heijden
    • 2
  • F. Johannes P. van Valenberg
    • 2
  • Wassim Kassouf
    • 1
    Email author
  1. 1.Division of UrologyMcGill University Health Center—Glen SiteMontrealCanada
  2. 2.Department of UrologyRadboud University Medical CentreNijmegenThe Netherlands
  3. 3.Urologic Oncology BranchNational Cancer InstituteBethesdaUSA
  4. 4.Department of UrologyColumbia UniversityNew YorkUSA
  5. 5.The James Buchanan Brady Urological InstituteThe Johns Hopkins University School of MedicineBaltimoreUSA
  6. 6.Urology Service, Department of SurgeryKimmel Center for Prostate and Urologic Cancers, Memorial Sloan Kettering Cancer CenterNew YorkUSA
  7. 7.Department of UrologyErasmus MC Cancer InstituteRotterdamThe Netherlands
  8. 8.Ingram Cancer CenterVanderbilt UniversityTennesseeUSA
  9. 9.Department of UrologyInstituto Valenciano de OncologíaValenciaSpain
  10. 10.Department of UrologyMD Anderson Cancer CenterHoustonUSA
  11. 11.Scott Department of UrologyBaylor College of MedicineHoustonUSA
  12. 12.Division of Urology, Department of Surgery and Surgical Oncology, Princess Margaret Cancer CentreUniversity of TorontoTorontoCanada
  13. 13.Department of Urology, Western General HospitalUniversity of EdinburghEdinburghUK
  14. 14.University of IowaIowa CityUSA
  15. 15.Department of UrologyUniversity of BaselBaselSwitzerland
  16. 16.Department of UrologyStanford University School of MedicineStanfordUSA
  17. 17.Department of Urology, Division of Urologic OncologyThe University of Texas Health San AntonioSan AntonioUSA

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