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World Journal of Urology

, Volume 37, Issue 4, pp 719–725 | Cite as

The change of IPSS 7 (nocturia) score has the maximum influence on the change of Qol score in patients with lower urinary tract symptoms

  • Woo Suk Choi
  • Hwancheol SonEmail author
Original Article
  • 175 Downloads

Abstract

Purpose

This study evaluated the factors affecting lower urinary tract symptom (LUTS)-related quality-of-life (Qol) scores and the change in the Qol scores following treatment.

Methods

This pooled data analysis study collected the international prostate symptom score (IPSS) with Qol score from five studies which evaluated the change in the IPSS after medication for LUTS. Post-treatment IPSS with Qol scores were measured at 3 months after the initiation of medication.

Results

The mean age of 444 men was 62.5 ± 8.5 years. The mean IPSS total and Qol score at baseline were 18.6 ± 6.7 points and 4.0 ± 0.9 points, respectively. Each IPSS item score, except IPSS 3, was found to be an independent factor that had an influence on baseline Qol scores, with IPSS 7 (nocturia) showing the most significant correlation. After 3 months’ medication, IPSS total and Qol score were significantly decreased to 11.7 ± 6.4 (p < 0.001) and 2.9 ± 1.2 points (p < 0.001), respectively. On multivariate analysis, the improvements in IPSS item 2, 4, 5, and 7 scores were found to be independent factors that had an influence on the improvement in Qol scores. The improvement in IPSS 7 had maximum influence on the improvement in Qol score. Among men with a decrease in total IPSS score by 5 or more points but without improvement in nocturia, Qol was not improved in one-third of them.

Conclusions

Storage symptoms had a greater influence on QoL scores than voiding symptoms. The improvement in nocturia after treatment was the most important factor for the improvement in Qol.

Keywords

Lower urinary tract symptoms Prostate Quality of life 

Notes

Compliance with ethical standards

Ethical standard

For this type of study, formal consent is not required.

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

345_2018_2410_MOESM1_ESM.docx (17 kb)
Supplementary material 1 (DOCX 17 kb)
345_2018_2410_MOESM2_ESM.xlsx (188 kb)
Supplementary material 2 (XLSX 189 kb)

References

  1. 1.
    Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S, Coyne K, Kelleher C, Hampel C, Artibani W, Abrams P (2006) Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. Eur Urol 50(6):1306–1314.  https://doi.org/10.1016/j.eururo.2006.09.019 (discussion 1314-1305) CrossRefGoogle Scholar
  2. 2.
    Coyne KS, Sexton CC, Thompson CL, Milsom I, Irwin D, Kopp ZS, Chapple CR, Kaplan S, Tubaro A, Aiyer LP, Wein AJ (2009) The prevalence of lower urinary tract symptoms (LUTS) in the USA, the UK and Sweden: results from the Epidemiology of LUTS (EpiLUTS) study. BJU Int 104(3):352–360.  https://doi.org/10.1111/j.1464-410X.2009.08427.x CrossRefGoogle Scholar
  3. 3.
    Sarma AV, Wei JT (2012) Clinical practice. Benign prostatic hyperplasia and lower urinary tract symptoms. N Engl J Med 367(3):248–257.  https://doi.org/10.1056/NEJMcp1106637 CrossRefGoogle Scholar
  4. 4.
    Barry MJ, Fowler FJ Jr, O’Leary MP, Bruskewitz RC, Holtgrewe HL, Mebust WK, Cockett AT (2012) The American Urological Association symptom index for benign prostatic hyperplasia. The Measurement Committee of the American Urological Association. J Urol 148(5):1549–1557 (discussion 1564) Google Scholar
  5. 5.
    Barry MJ (2001) Evaluation of symptoms and quality of life in men with benign prostatic hyperplasia. Urology 58(6 Suppl 1):25–32 (discussion 32) CrossRefGoogle Scholar
  6. 6.
    Yoshimura K, Arai Y, Ichioka K, Terada N, Matsuta Y, Okubo K (2002) Symptom-specific quality of life in patients with benign prostatic hyperplasia. Int J Urol 9(9):485–490CrossRefGoogle Scholar
  7. 7.
    Perrin P, Marionneau N, Cucherat M, Taieb C (2005) Relationship between lower urinary tract symptoms frequency assessed by the IPSS and bothersomeness (SPI) among men older than 50 years old. Eur Urol 48(4):601–607.  https://doi.org/10.1016/j.eururo.2005.06.013 CrossRefGoogle Scholar
  8. 8.
    Ojewola RW, Oridota ES, Balogun OS, Ogundare EO, Alabi TO (2016) Lower urinary tract symptoms: prevalence, perceptions, and healthcare-seeking behavior amongst Nigerian men. World J Mens Health 34(3):200–208.  https://doi.org/10.5534/wjmh.2016.34.3.200 CrossRefGoogle Scholar
  9. 9.
    Adegun PT, Adebayo PB, Areo PO (2016) Severity of lower urinary tract symptoms among middle aged and elderly nigerian men: impact on quality of life. Adv Urol 2016:1015796.  https://doi.org/10.1155/2016/1015796 CrossRefGoogle Scholar
  10. 10.
    McVary KT, Peterson A, Donatucci CF, Baygani S, Henneges C, Clouth J, Wong D, Oelke M (2016) Use of structural equation modeling to demonstrate the differential impact of storage and voiding lower urinary tract symptoms on symptom bother and quality of life during treatment for lower urinary tract symptoms associated with benign prostatic hyperplasia. J Urol 196(3):824–830.  https://doi.org/10.1016/j.juro.2016.04.062 CrossRefGoogle Scholar
  11. 11.
    Choi WS, Heo NJ, Lee YJ, Son H (2017) Factors that influence lower urinary tract symptom (LUTS)-related quality of life (QoL) in a healthy population. World J Urol.  https://doi.org/10.1007/s00345-017-2052-2 Google Scholar
  12. 12.
    Apostolidis A, Kirana PS, Chiu G, Link C, Tsiouprou M, Hatzichristou D (2009) Gender and age differences in the perception of bother and health care seeking for lower urinary tract symptoms: results from the hospitalised and outpatients’ profile and expectations study. Eur Urol 56(6):937–947.  https://doi.org/10.1016/j.eururo.2009.07.050 CrossRefGoogle Scholar
  13. 13.
    Roe B, Doll H, Wilson K (1999) Help seeking behaviour and health and social services utilisation by people suffering from urinary incontinence. Int J Nurs Stud 36(3):245–253CrossRefGoogle Scholar
  14. 14.
    Kaplan SA, Roehrborn CG, Rovner ES, Carlsson M, Bavendam T, Guan Z (2006) Tolterodine and tamsulosin for treatment of men with lower urinary tract symptoms and overactive bladder: a randomized controlled trial. JAMA 296(19):2319–2328.  https://doi.org/10.1001/jama.296.19.2319 CrossRefGoogle Scholar
  15. 15.
    Bliwise DL, Rosen RC, Baum N (2014) Impact of nocturia on sleep and quality of life: a brief, selected review for the International Consultation on Incontinence Research Society (ICI-RS) nocturia think tank. Neurourol Urodyn 33(Suppl 1):S15–S18.  https://doi.org/10.1002/nau.22585 CrossRefGoogle Scholar
  16. 16.
    Andersson F, Anderson P, Holm-Larsen T, Piercy J, Everaert K, Holbrook T (2016) Assessing the impact of nocturia on health-related quality-of-life and utility: results of an observational survey in adults. J Med Econ 19(12):1200–1206.  https://doi.org/10.1080/13696998.2016.1211136 CrossRefGoogle Scholar
  17. 17.
    Oelke M, Wiese B, Berges R (2014) Nocturia and its impact on health-related quality of life and health care seeking behaviour in German community-dwelling men aged 50 years or older. World J Urol 32(5):1155–1162.  https://doi.org/10.1007/s00345-014-1374-6 CrossRefGoogle Scholar
  18. 18.
    Miranda Ede P, Gomes CM, Torricelli FC, de Bessa JJ, de Castro JE, Ferreira BR, Scafuri AG, Bruschini H, Srougi M (2014) Nocturia is the lower urinary tract symptom with greatest impact on quality of life of men from a community setting. Int Neurourol J 18(2):86–90.  https://doi.org/10.5213/inj.2014.18.2.86 CrossRefGoogle Scholar
  19. 19.
    Kok ET, Bohnen AM, Groeneveld FP, Busschbach JJ, Blanker MH, Bosch JL (2005) Changes in disease specific and generic quality of life related to changes in lower urinary tract symptoms: the Krimpen study. J Urol 174(3):1055–1058.  https://doi.org/10.1097/01.ju.0000169256.74421.e5 CrossRefGoogle Scholar
  20. 20.
    Sarma AV, Jacobsen SJ, Girman CJ, Jacobson DJ, Roberts RO, Rhodes T, Lieber M (2002) Concomitant longitudinal changes in frequency of and bother from lower urinary tract symptoms in community dwelling men. J Urol 168(4 Pt 1):1446–1452.  https://doi.org/10.1097/01.ju.0000028220.74089.ba CrossRefGoogle Scholar
  21. 21.
    Masumori N, Tsukamoto T, Rhodes T, Girman CJ (2003) Natural history of lower urinary tract symptoms in men—result of a longitudinal community-based study in Japan. Urology 61(5):956–960CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of UrologyKonkuk University School of Medicine, Konkuk University Medical CenterSeoulSouth Korea
  2. 2.Department of UrologySeoul National University College of Medicine, SMG-SNU Boramae HospitalSeoulSouth Korea

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